Disposition Kinetics of Taxanes in Peritoneal Dissemination

Table 1

The values of AUC of paclitaxel and docetaxel in plasma and ascitic fluid after an i.p. infusion of Taxol and Taxotere in patients with peritoneal tumor [7].

		AUCp	AUCa	Ratio of
		(mg*hr/L)	(mg*hr/L)	AUCa/AUCp
Paclitaxel	120 mg	2.57 ± 1.43	1,298 ± 238	505
	180 mg	1.30 ± 0.86	2,214 ± 128	1705
Docetaxel	60 mg	6.65 ± 3.75	370 ± 87	56
	80 mg	2.27 ± 0.65	238 ± 24	105

The value of AUC was calculated from 0 to 25 h including the period of the infusion administration.
Each value represents the mean ± SE of three patients.
*Significantly different from Taxotere at P < 0.01.