Molecular Detection of Antibiotic Resistance in South African Isolates of Helicobacter pylori
Table 1
Mutations associated with resistance to clarithromycin and fluoroquinolone.
Mutant strain
Number of independent mutations analysed
Mutant allelesa
Designation
Amino acid change
MIC (µg/mL)
245A
1
23SMUT3
A2147G
256
245C
1
23SMUT3
A2147G
32
247A
2
23SMUT3 No gyr 87 WT
A2147G N87K
256
247C
1
No gyr 87 WT
N87K
8
249A
1
No gyr 87 WT
N87K
32
249C
1
No gyr 87 WT
N87K
16
252A
2
No gyr 87 WT 23SMUT3
N87K A2147G
32
252C
4
No gyr 87 WT gyr 91 WT 23SMUT2 23SMUT3
N87K D91N A2146C A2147G
32
253C
1
No gyr 87 WT
N87K
16
254A
1
23SMUT3
A2147G
256
119A
1
23SMUT3
A2147G
32
275A
1
23SMUT3
A2147G
128
305A
1
23SMUT3
A2147G
64
305C
1
23SMUT3
A2147G
128
369A
1
No gyr 87 WT
N87K
16
436C
1
23SMUT3
A2147G
256
499C
1
23SMUT3
A2147G
64
aDistinct mutation identified is given an allele name (designation), which represents a specific change at the nucleotide (nt) in a gene and a corresponding amino acid change in the gene product.