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Gastroenterology Research and Practice
Volume 2013, Article ID 275392, 7 pages
http://dx.doi.org/10.1155/2013/275392
Clinical Study

Prognostic Significance of DR-70 Levels in Dysplastic Colorectal Polyps

1Department of Gastroenterology, Haydarpaşa Numune Training and Research Hospital, Istanbul, Turkey
2Department of Internal Medicine, Haydarpaşa Numune Training and Research Hospital, Istanbul, Turkey
3Department of Gastroenterology, Medeniyet University, Istanbul, Turkey
4Duzen Laboratories, Istanbul, Turkey

Received 11 June 2013; Revised 20 September 2013; Accepted 4 October 2013

Academic Editor: D. Fan

Copyright © 2013 Atakan Yesil et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Background. To investigate the relationship between DR-70 serum levels and dysplastic colon polyps. Materials and Methods. A total of 130 patients with adenomatous polyps detected by colonoscopy and divided into two groups including low versus high grade polyp, along with 50 healthy blood donors were included in the study. Blood samples from each participant were analyzed for serum CEA and DR-70 levels. Results. No statistically significant differences were observed between the two groups in terms of age or gender. The median DR-70 level was 0.5 μg/mL in the healthy control group and 1.1 μg/mL in group 1b (i.e., the high grade polyp) ( ). DR-70 was higher in group 1b as compared to group 1a ( ). However, the median DR-70 values for the low grade polyp group (i.e., group 1a) and the control group were similar ( ). In order to determine independent predictors of high grade dysplasia, CEA, DR-70, polyp size, and age parameters were subjected to multiple logistical regression analyses via the Enter method; the model was statistically significant ( ). Conclusions. DR-70, a marker used to measure FDP, which is generated by all major cancers, is a potential marker to identify patients with advanced adenomatous polyps, that is, precursors of colorectal cancer.