The Role of IL-6, 8, and 10, sTNFr, CRP, and Pancreatic Elastase in the Prediction of Systemic Complications in Patients with Acute Pancreatitis

Table 4

ROC analysis for biochemical parameters of patients with acute pancreatitis. The criterion of classifying patients is the occurrence or absence of systemic complications of the disease. Bold printed are the indicators with statistically significant difference.

Parameters	AUC (95% CI)	𝑃 value	Cut-off	Sensitivity (%)	Specificit  (%)	PPV (%)	NPV (%)
IL-6 (1st day) [pg/mL]	0.71 (0.63–0.78)	<0.001	37.9	82	65	35	94
IL-8 (1st day) [pg/mL]	0.66 (0.58–0.74)	0.008	42.5	68	67	32	90
IL-10 (1st day) [pg/mL]	0.65 (0.57–0.73)	0.013	7.2	75	56	28	91
sTNFr (1st day) [pg/mL]	0.69 (0.60–0.76)	0.002	1552	82	53	29	93
CRP (1st day)	0.51 (0.43–0.60)	0.842	85	32	86	35	85
CRP (3rd day) (mg/L)	0.69 (0.61–0.77)	0.001	214	54	84	44	89
Elastase (1st day) (ng/mL)	0.56 (0.48–0.64)	0.311	2.0	92	22	22	93
Elastase (3rd day) (ng/mL)	0.70 (0.62–0.77)	<0.001	1.5	93	43	27	96