Time Course of the Development of Nonalcoholic Fatty Liver Disease in the Otsuka Long-Evans Tokushima Fatty Rat
Figure 4
Expression of genes related to lipogenesis. Levels of SREBP-1c, SCD-1, chREBP, FAS, and ACC mRNA in the liver at 10, 30, and 50 weeks of age. ((a)–(e)) Sterol regulatory element-binding protein (SREBP) 1c, stearoyl-CoA- (SCD-) 1, carbohydrate response element-binding protein (chREBP), fatty acid synthase (FAS), and acetyl-CoA carboxylase (ACC) mRNA levels, respectively. Mean values were obtained from livers of 3 separate animals. Polymerase chain reactions performed in duplicate. The transcript levels normalized relative to GAPDH expression. Data are expressed as means ± SD. * compared with LETO rats.
