PP2A-Mediated Anticancer Therapy

Table 1

Nomenclature of subunits of PP2A and the subcellular distribution.

Subunit	Gene name	Gene locus	Isoforms	Aliases	Subcellular distribution	References
A	PPP2R1A	19q13.14	A𝛼	PR65𝛼	Cytoplasm	[1, 25, 54, 55]
	PPP2R1B	11q23.1	A𝛽	PR65𝛽	Cytoplasm	[1, 13, 25, 54]
B	PPP2R2A	8p21.1	B𝛼	PR55𝛼, B55𝛼	Cytoplasm, microtubules, neurofilaments, vimentin, membrane, nucleus, Golgi/reticulum	[1, 25, 54]
	PPP2R2B	5q32	B𝛽	PR55𝛽, B55𝛽	Cytosol	[1, 25, 54, 56]
	PPP2R2C	4p16.1	B𝛾	PR55𝛾, B55𝛾	Cytoskeletal fraction	[1, 25, 54, 57]
	PPP2R2D	10q26.3	B𝛿	PR55𝛿, B55𝛿	Cytosol	[1, 25, 54]
B′	PPP2R5A	1q32.3	B′𝛼	PR61𝛼, B56𝛼	Cytoplasm	[1, 25, 54]
	PPP2R5B	11q13.1	B′𝛽	PR61𝛽1, B56𝛽, PR61𝛽2	Cytoplasm	[1, 25, 54, 58]
	PPP2R5C	14q32.31	B′𝛾1; B′𝛾2; B′𝛾3	PR61𝛾1, B56𝛾1, B′𝛼3; PR61𝛾2, B56𝛾2, B′𝛼2; B56𝛾3, B′𝛼1	Cytoplasm, nucleus, focal; adhesion	[1, 25, 54]
	PPP2R5D	6p21.1	B′𝛿	PR61𝛿, B56𝛿	Cytosol, mitochondria, nucleus, microsomes	[1, 25, 54]
	PPP2R5E	14q23.2	B′𝜀	PR61𝜀, B56𝜀	Cytoplasm	[1, 25, 54]
B′′	PPP2R3A	3q22.1	B′′𝛼1; B′′𝛼2	PR130; PR72	Centrosome and Golgi; Cytosol	[1, 25, 54, 59]
	PPP2R3B	Xp22.33	B′′𝛽1; B′′𝛽2	PR48; PR59	Nucleus	[1, 25, 54]
	PPP2R3C		B′′𝛾	G5PR	Nucleus	[1, 25, 54]
B′′′	STRN	2p22.2		PR110, PR93	Membrane and cytoplasm	[1, 25, 54]
	STRN3	14q12		PR112, PR102,PR94	nucleus	[1, 25, 54]
C	PPP2CA	5q31.1	C𝛼	PP2A𝛼	Cytoplasm and nucleus	[1, 25, 54]
	PPP2CB	8p12	C𝛽	PP2A𝛽	Cytoplasm and nucleus	[1, 25, 54, 60]