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Gastroenterology Research and Practice
Volume 2013 (2013), Article ID 681439, 18 pages
Review Article

Screening for Precancerous Lesions of Upper Gastrointestinal Tract: From the Endoscopists' Viewpoint

1Department of Internal Medicine, National Taiwan University Hospital, College of Medicine, National Taiwan University, Chung-Shan South Road, Taipei 100, Taiwan
2Department of Internal Medicine, Far Eastern Memorial Hospital, Banciao District, New Taipei City, Taiwan

Received 3 November 2012; Accepted 19 February 2013

Academic Editor: Fayez Sandouk

Copyright © 2013 Chen-Shuan Chung and Hsiu-Po Wang. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Upper gastrointestinal tract cancers are one of the most important leading causes of cancer death worldwide. Diagnosis at late stages always brings about poor outcome of these malignancies. The early detection of precancerous or early cancerous lesions of gastrointestinal tract is therefore of utmost importance to improve the overall outcome and maintain a good quality of life of patients. The desire of endoscopists to visualize the invisibles under conventional white-light endoscopy has accelerated the advancements in endoscopy technologies. Nowadays, image-enhanced endoscopy which utilizes optical- or dye-based contrasting techniques has been widely applied in endoscopic screening program of gastrointestinal tract malignancies. These contrasting endoscopic technologies not only improve the visualization of early foci missed by conventional endoscopy, but also gain the insight of histopathology and tumor invasiveness, that is so-called optical biopsy. Here, we will review the application of advanced endoscopy technique in screening program of upper gastrointestinal tract cancers.