Associations of miR-499 and miR-34b/c Polymorphisms with Susceptibility to Hepatocellular Carcinoma: An Evidence-Based Evaluation
Table 2
Meta-analysis of the association between SNP miR-499 (T>C) rs3746444 and susceptibility to HCC.
Genetic model
Population
OR
95% CI
-h
Allele frequency C versus T
Overall
1.01
0.72–1.43
0.06
0.95
0.0008
Asian
0.99
0.62–1.59
0.04
0.97
0.0004
HBV infected
0.96
0.59–1.56
0.16
0.87
0.001
HWE
1.13
0.64–2.01
0.43
0.67
0.001
Heterozygous model TC versus TT
Overall
0.96
0.77–1.19
0.39
0.70
0.23
Asian
0.95
0.75–1.21
0.38
0.70
0.13
HBV infected
0.83
0.54–1.28
0.83
0.40
0.09
HWE
1.04
0.66–1.63
0.17
0.86
0.07
Homozygous model CC versus TT
Overall
0.96
0.44–2.09
0.10
0.92
0.006
Asian
0.87
0.27–2.85
0.23
0.82
0.003
HBV infected
1.04
0.45–2.43
0.10
0.92
0.04
HWE
1.24
0.36–4.34
0.34
0.73
0.02
Dominant model TC + CC versus TT
Overall
1.00
0.71–1.42
0.00
1.00
0.02
Asian
0.99
0.63–1.55
0.03
0.97
0.009
HBV infected
0.90
0.53–1.53
0.40
0.69
0.01
HWE
1.12
0.63–1.99
0.37
0.71
0.009
Recessive model CC versus TT + TC
Overall
0.97
0.50–1.88
0.08
0.93
0.02
Asian
0.86
0.30–2.45
0.28
0.78
0.009
HBV infected
1.23
0.86–1.75
1.15
0.25
0.12
HWE
1.22
0.43–3.47
0.37
0.71
0.06
OR: odds ratio; 95% CI: 95% confidence interval; : value for -test; : value for -test; -h: value for -test; HBV infected: subgroup analysis in hepatitis B virus (HBV) infected cases. HWE: only studies that conform to Hardy-Weinberg equilibrium were included in this subgroup analysis.
