Expression of Potential Cancer Stem Cell Marker ABCG2 is Associated with Malignant Behaviors of Hepatocellular Carcinoma
Table 1
ABCG2 expression and characteristics of patients.
ABCG2 Expression
-value
Positive ()
Negative ()
Age
>50
14 (66.7%)
7 (70%)
0.992
≤50
7 (33.3%)
3 (30%)
Gender
Male
20 (95.2%)
6 (60%)
0.027
Female
1 (4.8%)
4 (40%)
HBsAg
Positive
14 (66.7%)
7 (70%)
0.992
Negative
7 (33.3%)
3 (30%)
AFP (ng/mL)
≤20
8 (38.1%)
2 (20%)
0.420
>20
13 (61.9%)
8 (80%)
TNM
I/II
15 (71.4%)
7 (70%)
1.000
III/IV
6 (28.6%)
3 (30%)
BCLC
0/A
10 (47.6%)
7 (70%)
0.280
B/C/D
11 (52.4%)
3 (30%)
Differentiation
Poor
3 (16.7%)
1 (10%)
1.000
Moderate-Well
18 (83.3%)
9 (90%)
Tumor number
Single
17 (81.0%)
8 (80%)
1.000
Multiple
4 (19.0%)
2 (20%)
Tumor size
<5
9 (42.9%)
5 (50%)
1.000
≥5
12 (57.1%)
5 (50%)
Microvascular invasion
Present
8 (38.1%)
3 (30%)
0.996
Absent
13 (61.9%)
7 (70%)
Macrovascular invasion
Present
6 (28.6%)
1 (10%)
0.379
Absent
15 (71.4%)
9 (90%)
Milan
In
8 (38.1%)
5 (50%)
0.700
Out
13 (61.9%)
5 (50%)
Ki67
≤20%
9 (42.9%)
6 (60%)
0.458
>20%
12 (57.1%)
4 (40%)
AFP: α-fetoprotein; TNM: TNM staging system of the International Union Against Cancer; BCLC: Barcelona Clinic Liver Cancer staging system; Milan: Milan criteria.