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Gastroenterology Research and Practice
Volume 2013, Article ID 856873, 9 pages
http://dx.doi.org/10.1155/2013/856873
Review Article

Cronkhite-Canada Syndrome: Review of the Literature

12nd Department of Medicine, Charles University in Praha, Faculty of Medicine at Hradec Králové, University Teaching Hospital, Sokolska 581, 500 05 Hradec Králové, Czech Republic
2Department of Gastroenterology, Vitkovice Hospital, Zalužanského 1192/15, 703 00 Ostrava-Vítkovice, Czech Republic
3The Fingerland Department of Pathology, Charles University in Praha, Faculty of Medicine at Hradec Králové, University Teaching Hospital, Sokolska 581, 500 05 Hradec Králové, Czech Republic

Received 11 April 2013; Accepted 30 October 2013

Academic Editor: Antonin Vavrecka

Copyright © 2013 Marcela Kopáčová et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Cronkhite-Canada syndrome is a rare disease characterised by diffuse polyposis of the gastrointestinal tract, diarrhoea, weight loss, abdominal pain, cutaneous hyperpigmentation, dystrophic changes of fingernails, and alopecia. The etiology is probably autoimmune and diagnosis is based on history, physical examination, endoscopic findings of gastrointestinal polyposis, and histology. The disease is very rare; about 450 cases have been described in the literature so far. We present a review of the literature with our own picture documentation of this rare condition.