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Gastroenterology Research and Practice
Volume 2014, Article ID 202960, 7 pages
Clinical Study

Clinicopathological and Immunohistochemical Characterisation of Gastric Schwannomas in 29 Cases

1Department of General Surgery, Tenth People's Hospital of Shanghai, Tongji University, School of Medicine, Shanghai 200072, China
2Department of Surgery, Beijing Cancer Hospital, Peking University School of Oncology, Beijing 100036, China
3Charité University Medicine, Department of General-, Visceral- and Vascular Surgery, Campus Benjamin Franklin, Hindenburgdamm 30, 12200 Berlin, Germany
4Department of Pathology, Tenth People's Hospital of Shanghai, Tongji University, School of Medicine, Shanghai 200072, China

Received 18 November 2013; Accepted 30 December 2013; Published 11 February 2014

Academic Editor: Paul Enck

Copyright © 2014 Lijun Zheng et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Schwannomas are tumors arising from the nervous system that also occur infrequently in the gastrointestinal tract, most commonly in the stomach. This report characterizes 29 patients with benign or malignant gastric schwannomas. Surgical data and clinical follow-up information were available for 28 cases with a median postoperative duration of 57 months. Clinicopathological and immunohistochemical characteristics of benign and malignant schwannomas were analysed. Four cases (13.7%) were histologically diagnosed with malignant schwannoma. All tumors were positive for S-100 and CD56 proteins, displaying a diffuse staining pattern. Vimentin was expressed in 100% cases and all schwannomas were negative for smooth muscle actin, c-kit, and HMB-45. A significant difference was observed between the group of benign and malignant schwannomas as regards recurrences and metastasis after complete resection ( ). The survival time of patients with benign schwannomas was longer than the malignant group ( ), so gastric malignant schwannomas have a potential for recurrence and metastasis, with subsequently short survival. Complete resection with an attempt to remove all tumor tissue with negative margins is of paramount importance in the management of gastric schwannomas, particularly when they turn out to be malignant.