Table of Contents Author Guidelines Submit a Manuscript
Gastroenterology Research and Practice
Volume 2014 (2014), Article ID 307805, 8 pages
http://dx.doi.org/10.1155/2014/307805
Review Article

The Effects of Baclofen for the Treatment of Gastroesophageal Reflux Disease: A Meta-Analysis of Randomized Controlled Trials

Department of Pharmacy, Zhujiang Hospital, Southern Medical University, No. 253 Industrial Road, Haizhu District, Guangzhou 510282, China

Received 21 May 2014; Revised 8 August 2014; Accepted 27 August 2014; Published 20 October 2014

Academic Editor: Spiros D. Ladas

Copyright © 2014 Shujie Li et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. J. Dent, P. J. Kahrilas, N. Vakil et al., “Clinical trial design in adult reflux disease: a methodological workshop,” Alimentary Pharmacology and Therapeutics, vol. 28, no. 1, pp. 107–126, 2008. View at Publisher · View at Google Scholar · View at Scopus
  2. N. Vakil, S. V. van Zanten, P. Kahrilas et al., “The Montreal definition and classification of gastroesophageal reflux disease: a global evidence-based consensus,” The American Journal of Gastroenterology, vol. 101, no. 8, pp. 1900–1920, 2006. View at Publisher · View at Google Scholar · View at Scopus
  3. N. B. Vakil, F. J. Huff, A. Bian, D. S. Jones, and D. Stamler, “Arbaclofen placarbil in GERD: a randomized, double-blind, placebo-controlled study,” The American Journal of Gastroenterology, vol. 106, no. 8, pp. 1427–1438, 2011. View at Publisher · View at Google Scholar · View at Scopus
  4. E. Savarino, P. Zentilin, R. Tutuian et al., “The role of nonacid reflux in NERD: lessons learned from impedance-pH monitoring in 150 patients off therapy,” The American Journal of Gastroenterology, vol. 103, no. 11, pp. 2685–2693, 2008. View at Publisher · View at Google Scholar · View at Scopus
  5. J. Sarosiek and R. W. McCallum, “Mechanisms of oesophageal mucosal defence,” Bailliere's Best Practice and Research in Clinical Gastroenterology, vol. 14, no. 5, pp. 701–717, 2000. View at Publisher · View at Google Scholar · View at Scopus
  6. J. Sarosiek, C. J. Scheurich, M. Marcinkiewicz, and R. W. McCallum, “Enhancement of salivary esophagoprotection: rationale for a physiological approach to gastroesophageal reflux disease,” Gastroenterology, vol. 110, no. 3, pp. 675–681, 1996. View at Publisher · View at Google Scholar · View at Scopus
  7. D. Chen, C. Barber, P. McLoughlin, P. Thavaneswaran, G. G. Jamieson, and G. J. Maddern, “Systematic review of endoscopic treatments for gastro-oesophageal reflux disease,” The British Journal of Surgery, vol. 96, no. 2, pp. 128–136, 2009. View at Publisher · View at Google Scholar · View at Scopus
  8. W. O. A. Rohof, D. P. Hirsch, and G. E. E. Boeckxstaens, “Pathophysiology and management of gastroesophageal reflux disease,” Minerva Gastroenterologica e Dietologica, vol. 55, no. 3, pp. 289–300, 2009. View at Google Scholar · View at Scopus
  9. C. A. M. Stedman and M. L. Barclay, “Review article: comparison of the pharmacokinetics, acid suppression and efficacy of proton pump inhibitors,” Alimentary Pharmacology and Therapeutics, vol. 14, no. 8, pp. 963–978, 2000. View at Publisher · View at Google Scholar · View at Scopus
  10. R. W. Brimblecombe, W. A. M. Duncan, G. J. Durant et al., “Characterization and development of cimetidine as a histamine H2-receptor antagonist,” Gastroenterology, vol. 74, no. 2, part 2, pp. 339–347, 1978. View at Google Scholar · View at Scopus
  11. R. Fass, M. Shapiro, R. Dekel, and J. Sewell, “Systematic review: Proton-pump inhibitor failure in gastro-oesophageal reflux disease—where next?” Alimentary Pharmacology and Therapeutics, vol. 22, no. 2, pp. 79–94, 2005. View at Publisher · View at Google Scholar · View at Scopus
  12. H. Beaumont and G. E. E. Boeckxstaens, “Does the presence of a hiatal hernia affect the efficacy of the reflux inhibitor baclofen during add-on therapy,” The American Journal of Gastroenterology, vol. 104, no. 7, pp. 1764–1771, 2009. View at Publisher · View at Google Scholar · View at Scopus
  13. L. Cange, E. Johnsson, H. Rydholm et al., “Baclofen-mediated gastro-oesophageal acid reflux control in patients with established reflux disease,” Alimentary Pharmacology and Therapeutics, vol. 16, no. 5, pp. 869–873, 2002. View at Publisher · View at Google Scholar · View at Scopus
  14. A. F. Ciccaglione and L. Marzio, “Effect of acute and chronic administration of the GABAB agonist baclofen on 24 hour pH metry and symptoms in control subjects and in patients with gastro-oesophageal reflux disease,” Gut, vol. 52, no. 4, pp. 464–470, 2003. View at Publisher · View at Google Scholar · View at Scopus
  15. M. J. Cossentino, K. Mann, S. P. Armbruster, J. M. Lake, C. Maydonovitch, and R. K. H. Wong, “Randomised clinical trial: The effect of baclofen in patients with gastro-oesophageal reflux—a randomised prospective study,” Alimentary Pharmacology & Therapeutics, vol. 35, no. 9, pp. 1036–1044, 2012. View at Publisher · View at Google Scholar · View at Scopus
  16. L. B. Gerson, F. J. Huff, A. Hila et al., “Arbaclofen placarbil decreases postprandial reflux in patients with gastroesophageal reflux disease,” The American Journal of Gastroenterology, vol. 105, no. 6, pp. 1266–1275, 2010. View at Publisher · View at Google Scholar · View at Scopus
  17. L. Grossi, M. Spezzaferro, L. F. Sacco, and L. Marzio, “Effect of baclofen on oesophageal motility and transient lower oesophageal sphincter relaxations in GORD patients: a 48-h manometric study,” Neurogastroenterology and Motility, vol. 20, no. 7, pp. 760–766, 2008. View at Publisher · View at Google Scholar · View at Scopus
  18. I. Lidums, A. Lehmann, H. Checklin, J. Dent, and R. H. Holloway, “Control of transient lower esophageal sphincter relaxations and reflux by the GABAB agonist baclofen in normal subjects,” Gastroenterology, vol. 118, no. 1, pp. 7–13, 2000. View at Publisher · View at Google Scholar · View at Scopus
  19. T. I. Omari, M. A. Benninga, L. Sansom, R. N. Butler, J. Dent, and G. P. Davidson, “Effect of baclofen on esophagogastric motility and gastroesophageal reflux in children with gastroesophageal reflux disease: a randomized controlled trial,” The Journal of Pediatrics, vol. 149, no. 4, pp. 474–468, 2006. View at Publisher · View at Google Scholar · View at Scopus
  20. M. A. van Herwaarden, M. Samsom, H. Rydholm, and A. J. P. M. Smout, “The effect of baclofen on gastro-oesophageal reflux, lower oesophageal sphincter function and reflux symptoms in patients with reflux disease,” Alimentary Pharmacology and Therapeutics, vol. 16, no. 9, pp. 1655–1662, 2002. View at Publisher · View at Google Scholar · View at Scopus
  21. Q. Xu, J. Pan, J. Yu et al., “Meta-analysis of methylcobalamin alone and in combination with lipoic acid in patients with diabetic peripheral neuropathy,” Diabetes Research and Clinical Practice, vol. 101, no. 2, pp. 99–105, 2013. View at Publisher · View at Google Scholar · View at Scopus
  22. Y. P. Mu, R. L. Liu, L. Q. Wang et al., “Moxifloxacin monotherapy for treatment of complicated intra-abdominal infections: a meta-analysis of randomised controlled trials,” International Journal of Clinical Practice, vol. 66, no. 2, pp. 210–217, 2012. View at Publisher · View at Google Scholar · View at Scopus
  23. D. Moher, A. Liberati, J. Tetzlaff et al., “Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement,” Annals of Internal Medicine, vol. 151, no. 4, pp. 264–269, 2009. View at Google Scholar
  24. D. Moher, A. R. Jadad, and P. Tugwell, “Assessing the quality of randomized controlled trials: current issues and future directions,” International Journal of Technology Assessment in Health Care, vol. 12, no. 2, pp. 195–208, 1996. View at Publisher · View at Google Scholar · View at Scopus
  25. D. Moher, B. Pham, A. Jones et al., “Does quality of reports of randomised trials affect estimates of intervention efficacy reported in meta-analyses?” The Lancet, vol. 352, no. 9128, pp. 609–613, 1998. View at Publisher · View at Google Scholar · View at Scopus
  26. S. A. Olivo, L. G. Macedo, I. C. Gadotti, J. Fuentes, T. Stanton, and D. J. Magee, “Scales to assess the quality of randomized controlled trials: a systematic review,” Physical Therapy, vol. 88, no. 2, pp. 156–175, 2008. View at Publisher · View at Google Scholar · View at Scopus
  27. T. Xenodemetropoulos, K. J. Khan, G. I. Leontiadis, D. Armstrong, and P. Moayyedi, “W1096 the gamma-aminobutyric acid (GABA) receptor agonist baclofen in the treatment of gastroesophageal reflux disease (GERD): a systematic review,” Gastroenterology, vol. 138, supplement 1, no. 5, pp. S–650, 2010. View at Publisher · View at Google Scholar
  28. I. Mainie, R. Tutuian, S. Shay et al., “Acid and non-acid reflux in patients with persistent symptoms despite acid suppressive therapy: a multicentre study using combined ambulatory impedance-pH monitoring,” Gut, vol. 55, no. 10, pp. 1398–1402, 2006. View at Publisher · View at Google Scholar · View at Scopus
  29. M. F. Vela, R. Tutuian, P. O. Katz, and D. O. Castell, “Baclofen decreases acid and non-acid post-prandial gastro-oesophageal reflux measured by combined multichannel intraluminal impedance and pH,” Alimentary Pharmacology and Therapeutics, vol. 17, no. 2, pp. 243–251, 2003. View at Publisher · View at Google Scholar · View at Scopus
  30. G. H. Koek, D. Sifrim, T. Lerut, J. Janssens, and J. Tack, “Effect of the GABAB agonist baclofen in patients with symptoms and duodeno-gastro-oesophageal reflux refractory to proton pump inhibitors,” Gut, vol. 52, no. 10, pp. 1397–1402, 2003. View at Publisher · View at Google Scholar · View at Scopus
  31. Q. Zhang, A. Lehmann, R. Rigda, J. Dent, and R. H. Holloway, “Control of transient lower oesophageal sphincter relaxations and reflux by the GABAB agonist baclofen in patients with gastro-oesophageal reflux disease,” Gut, vol. 50, no. 1, pp. 19–24, 2002. View at Publisher · View at Google Scholar · View at Scopus
  32. G. Sachs, J. M. Shin, and R. Hunt, “Novel approaches to inhibition of gastric acid secretion,” Current Gastroenterology Reports, vol. 12, no. 6, pp. 437–447, 2010. View at Publisher · View at Google Scholar · View at Scopus
  33. P. L. Peghini, P. O. Katz, N. A. Bracy, and D. O. Castell, “Nocturnal recovery of gastric acid secretion with twice-daily dosing of proton pump inhibitors,” American Journal of Gastroenterology, vol. 93, no. 5, pp. 763–767, 1998. View at Publisher · View at Google Scholar · View at Scopus
  34. G. Sachs, “Proton pump inhibitors and acid-related diseases,” Pharmacotherapy, vol. 17, no. 1, pp. 22–37, 1997. View at Google Scholar · View at Scopus
  35. L. Grossi, A. F. Ciccaglione, N. Travaglini, and L. Marzio, “Transient lower esophageal sphincter relaxations and gastroesophageal reflux episodes in healthy subjects and GERD patients during 24 hours,” Digestive Diseases and Sciences, vol. 46, no. 4, pp. 815–821, 2001. View at Publisher · View at Google Scholar · View at Scopus
  36. R. C. Orlando, “Overview of the mechanisms of gastroesophageal reflux,” The American Journal of Medicine, vol. 111, supplement 8A, pp. 174S–177S, 2001. View at Google Scholar
  37. G. E. E. Boeckxstaens, “Review article: the pathophysiology of gastro-oesophageal reflux disease,” Alimentary Pharmacology and Therapeutics, vol. 26, no. 2, pp. 149–160, 2007. View at Publisher · View at Google Scholar · View at Scopus
  38. W. C. Orr, S. Goodrich, S. Wright, K. Shepherd, and M. Mellow, “The effect of baclofen on nocturnal gastroesophageal reflux and measures of sleep quality: a randomized, cross-over trial,” Neurogastroenterology and Motility, vol. 24, no. 6, pp. 553.e253–559.e253, 2012. View at Publisher · View at Google Scholar · View at Scopus