ATP-Binding Cassette Genes Genotype and Expression: A Potential Association with Pancreatic Cancer Development and Chemoresistance?

Table 4

Pancreatic cancer cell line ABCB1 mRNA expression, haplotype, and sensitivity to gemcitabine.

Cell line	ABCB1 expression	ABCB1 haplotype	GEM IC50 (𝜇M)
AsPC-1	24.67	2677GG-3435CC	25.59
SU86.86	0.34	2677GG-3435CC	>100
PL-45	0.98	2677GG-3435CT	18.75
PANC-1	1	2677GT-3435TT	>100
BXPC-3	15.82	2677TT-3435TT	0.11
MiaPaca-2	0.75	2677TT-3435TT	1.90
CFPAC-1	1015.7	2677TT-3134TT	1.09

GEM: gemcitabine. The expression of ABCB1 gene is normalized to PMM1 and showed as x-fold relative to the expression in PANC-1 cells.