Table 2: Univariate and multivariate analysis of the prognostic effect of CIMP status and clinicopathological features in stage cases for DFS.

 Univariate analysisMultivariate analysisb
 No.5 yr DFS valueHR95% CI value

Age (yr)0.182
Stage0.049 0.242
CEA level0.304
Adjuvant chemotherapy0.849
 Not received1471.4%
CIMP epigenotype0.014 0.019
 Positive1231.3% 2.935(1.193–7.220) 

5-yr DFS: five-year disease-free survival, CIMP: CpG island methylator phenotype, CEA: carcinoembryonic antigen, HR: hazard ratio.
aProximal location included the cecum, ascending colon, hepatic flexure of colon, and transverse colon while distal location included the splenic flexure of colon, descending colon, sigmoid colon, and rectum.
bOnly factors which showed significant impact on DFS in the univariate analysis were included in the Cox regression analysis.