Table of Contents Author Guidelines Submit a Manuscript
Gastroenterology Research and Practice
Volume 2014, Article ID 473817, 9 pages
http://dx.doi.org/10.1155/2014/473817
Research Article

Identification of Aberrantly Expressed miRNAs in Gastric Cancer

The Seventh Department of Internal Medicine, The Affiliated Tumor Hospital of Harbin Medical University, Harbin, Heilongjiang 150081, China

Received 18 December 2013; Revised 31 March 2014; Accepted 1 April 2014; Published 1 June 2014

Academic Editor: Sergio Morini

Copyright © 2014 Dan Liu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. R. Siegel, D. Naishadham, and A. Jemal, “Cancer statistics,” CA: A Cancer Journal for Clinicians, vol. 63, pp. 11–30, 2013. View at Google Scholar
  2. Y. Lin, J. Ueda, S. Kikuchi et al., “Comparative epidemiology of gastric cancer between Japan and China,” World Journal of Gastroenterology, vol. 17, no. 39, pp. 4421–4428, 2011. View at Publisher · View at Google Scholar · View at Scopus
  3. H. Tang, Y. Kong, J. Guo et al., “Diallyl disulfide suppresses proliferation and induces apoptosis in human gastric cancer through Wnt-1 signaling pathway by up-regulation of miR-200b and miR-22,” Cancer Letters, vol. 340, no. 1, pp. 72–81, 2013. View at Google Scholar
  4. C. Li, J. F. Li, Q. Cai et al., “MiRNA-199a-3p: a potential circulating diagnostic biomarker for early gastric cancer,” Journal of Surgical Oncology, vol. 108, pp. 89–92, 2013. View at Google Scholar
  5. B. Mínguez and A. Lachenmayer, “Diagnostic and prognostic molecular markers in hepatocellular carcinoma,” Disease Markers, vol. 31, no. 3, pp. 181–190, 2011. View at Publisher · View at Google Scholar · View at Scopus
  6. X. Li, F. Luo, Q. Li et al., “Identification of new aberrantly expressed miRNAs in intestinal-type gastric cancer and its clinical significance,” Oncology Reports, vol. 26, no. 6, pp. 1431–1439, 2011. View at Publisher · View at Google Scholar · View at Scopus
  7. S. P. Nana-Sinkam and C. M. Croce, “Clinical applications for microRNAs in cancer,” Clinical Pharmacology and Therapeutics, vol. 93, pp. 98–104, 2013. View at Google Scholar
  8. Y. Shimono, M. Zabala, R. W. Cho et al., “Downregulation of miRNA-200c links breast cancer stem cells with normal stem cells,” Cell, vol. 138, no. 3, pp. 592–603, 2009. View at Publisher · View at Google Scholar · View at Scopus
  9. P. Trang, J. F. Wiggins, C. L. Daige et al., “Systemic delivery of tumor suppressor microRNA mimics using a neutral lipid emulsion inhibits lung tumors in mice,” Molecular Therapy, vol. 19, no. 6, pp. 1116–1122, 2011. View at Publisher · View at Google Scholar · View at Scopus
  10. S. Volinia, M. Galasso, S. Costinean et al., “Reprogramming of miRNA networks in cancer and leukemia,” Genome Research, vol. 20, no. 5, pp. 589–599, 2010. View at Publisher · View at Google Scholar · View at Scopus
  11. W. Cao, R. Fan, L. Wang et al., “Expression and regulatory function of miRNA-34a in targeting survivin in gastric cancer cells,” Tumour Biology, vol. 34, pp. 963–971, 2013. View at Google Scholar
  12. Y. Yao, A. Suo, Z. Li et al., “MicroRNA profiling of human gastric cancer,” Molecular Medicine Reports, vol. 2, no. 6, pp. 963–970, 2009. View at Publisher · View at Google Scholar · View at Scopus
  13. D. Liu, P. Xia, D. Diao et al., “MiRNA-429 suppresses the growth of gastric cancer cells in vitro,” Journal of Biomedical Research, vol. 26, pp. 389–393, 2012. View at Google Scholar
  14. F. Wang, T. Li, B. Zhang et al., “MicroRNA-19a/b regulates multidrug resistance in human gastric cancer cells by targeting PTEN,” Biochemical and Biophysical Research Communications, vol. 434, pp. 688–694, 2013. View at Google Scholar
  15. T. Beissbarth, “Interpreting experimental results using gene ontologies,” Methods in Enzymology, vol. 411, pp. 340–352, 2006. View at Publisher · View at Google Scholar · View at Scopus
  16. T. S. Yang, X. H. Yang, X. D. Wang, Y. L. Wang, B. Zhou, and Z. S. Song, “MiR-214 regulate gastric cancer cell proliferation, migration and invasion by targeting PTEN,” Cancer Cell International, vol. 13, p. 68, 2013. View at Google Scholar
  17. B. Jiang, Z. Li, W. Zhang et al., “miR-874 Inhibits cell proliferation, migration and invasion through targeting aquaporin-3 in gastric cancer,” Journal of Gastroenterology. In press.
  18. X. Liu, J. Ru, J. Zhang et al., “miR-23a targets interferon regulatory factor 1 and modulates cellular proliferation and paclitaxel-induced apoptosis in gastric adenocarcinoma cells,” PLoS ONE, vol. 8, Article ID e64707, 2013. View at Google Scholar
  19. C. Wong, C. C. Wong, J. M. Lee, D. N. Fan, S. L. Au, and I. O. Ng, “Sequential alterations of microrna expression in hepatocellular carcinoma development and venous metastasis,” Hepatology, vol. 55, no. 5, pp. 1453–1461, 2012. View at Publisher · View at Google Scholar · View at Scopus
  20. T. Nishizawa and H. Suzuki, “The role of microRNA in gastric malignancy,” International Journal of Molecular Sciences, vol. 14, pp. 9487–9496, 2013. View at Google Scholar
  21. J. Guo, Y. Miao, B. Xiao et al., “Differential expression of microRNA species in human gastric cancer versus non-tumorous tissues,” Journal of Gastroenterology and Hepatology, vol. 24, no. 4, pp. 652–657, 2009. View at Publisher · View at Google Scholar · View at Scopus
  22. Y. Zhang, J. Guo, D. Li et al., “Down-regulation of miR-31 expression in gastric cancer tissues and its clinical significance,” Medical Oncology, vol. 27, no. 3, pp. 685–689, 2010. View at Publisher · View at Google Scholar · View at Scopus
  23. E. M. Laurila and A. Kallioniemi, “The diverse role of miR-31 in regulating cancer associated phenotypes,” Genes, Chromosomes and Cancer, vol. 52, no. 12, pp. 1103–1113, 2013. View at Google Scholar
  24. B. Q. Yu, L. P. Su, J. F. Li et al., “microRNA expression signature of gastric cancer cells relative to normal gastric mucosa,” Molecular Medicine Reports, vol. 6, pp. 821–826, 2012. View at Google Scholar
  25. H. Tang, M. Deng, Y. Tang et al., “miR-200b and miR-200c as prognostic factors and mediators of gastric cancer cell progression,” Clinical Cancer Research, vol. 19, no. 20, pp. 5602–5612, 2013. View at Google Scholar
  26. L. Mulrane, S. F. Madden, D. J. Brennan et al., “miR-187 is an independent prognostic factor in breast cancer and confers increased invasive potential in vitro,” Clinical Cancer Research, vol. 18, pp. 6702–6713, 2012. View at Google Scholar
  27. Y. Choudhury, F. C. Tay, D. H. Lam et al., “Attenuated adenosine-to-inosine editing of microRNA-376a* promotes invasiveness of glioblastoma cells,” Journal of Clinical Investigation, vol. 122, pp. 4059–4076, 2012. View at Google Scholar
  28. B. Zhao, H. Han, J. Chen et al., “microRNA let-7c inhibits migration and invasion of human non-small cell lung cancer by targeting ITGB3 and MAP4K3,” Cancer Letters, vol. 342, no. 1, pp. 43–51, 2013. View at Google Scholar
  29. V. Borgdorff, M. E. Lleonart, C. L. Bishop et al., “Multiple microRNAs rescue from Ras-induced senescence by inhibiting p21 (Waf1/Cip1),” Oncogene, vol. 29, no. 15, pp. 2262–2271, 2010. View at Publisher · View at Google Scholar · View at Scopus
  30. M. T. Ma, M. He, Y. Wang et al., “MiR-487a resensitizes mitoxantrone (MX)-resistant breast cancer cells (MCF-7/MX) to MX by targeting breast cancer resistance protein (BCRP/ABCG2),” Cancer Letters, vol. 339, pp. 107–115, 2013. View at Google Scholar
  31. F. Lin, X. Wang, Z. Jie et al., “Inhibitory effects of miR-146b-5p on cell migration and invasion of pancreatic cancer by targeting MMP16,” Journal of Huazhong University of Science and Technology—Medical Science, vol. 31, no. 4, pp. 509–514, 2011. View at Publisher · View at Google Scholar · View at Scopus
  32. G. W. Novotny, K. C. Belling, J. B. Bramsen et al., “MicroRNA expression profiling of carcinoma in situ cells of the testis,” Endocrine-Related Cancer, vol. 19, pp. 365–379, 2012. View at Google Scholar
  33. T. C. Shih, Y. J. Tien, C. J. Wen et al., “MicroRNA-214 downregulation contributes to tumor angiogenesis by inducing secretion of the hepatoma-derived growth factor in human hepatoma,” Journal of Hepatology, vol. 57, pp. 584–591, 2012. View at Google Scholar
  34. B. Li, Q. Han, Y. Zhu, Y. Yu, J. Wang, and X. Jiang, “Down-regulation of miR-214 contributes to intrahepatic cholangiocarcinoma metastasis by targeting Twist,” FEBS Journal, vol. 279, pp. 2393–2398, 2012. View at Google Scholar
  35. C. X. Xu, M. Xu, L. Tan et al., “MicroRNA miR-214 regulates ovarian cancer cell stemness by targeting p53/Nanog,” The Journal of Biological Chemistry, vol. 287, pp. 34970–34978, 2012. View at Google Scholar
  36. X. Wang, J. Chen, F. Li et al., “MiR-214 inhibits cell growth in hepatocellular carcinoma through suppression of beta-catenin,” Biochemical and Biophysical Research Communications, vol. 428, pp. 525–531, 2012. View at Google Scholar
  37. Z. Wotschofsky, J. Busch, M. Jung et al., “Diagnostic and prognostic potential of differentially expressed miRNAs between metastatic and non-metastatic renal cell carcinoma at the time of nephrectomy,” Clinica Chimica Acta, vol. 416, pp. 5–10, 2013. View at Google Scholar
  38. Y. Li, J. Xie, X. Xu et al., “MicroRNA-548 down-regulates host antiviral response via direct targeting of IFN-lambda1,” Protein & Cell, vol. 4, pp. 130–141, 2013. View at Google Scholar
  39. L. Zheng, T. Qi, D. Yang et al., “microRNA-9 suppresses the proliferation, invasion and metastasis of gastric cancer cells through targeting cyclin D1 and Ets1,” PLoS ONE, vol. 8, Article ID e55719, 2013. View at Google Scholar
  40. Y. Guo, L. Ying, Y. Tian et al., “miR-144 downregulation increases bladder cancer cell proliferation by targeting EZH2 and regulating Wnt signaling,” FEBS Journal, vol. 280, pp. 4531–4538, 2013. View at Google Scholar