Review Article

Diagnostic Performance of Des-γ-carboxy Prothrombin for Hepatocellular Carcinoma: A Meta-Analysis

Table 1

Main characteristics of the studies included in the meta-analysis.

NumberStudyTPFPFNTNN Assay typeDCP cutoff value (mAU/mL)EthnicitySmall HCC

1 Baek et al., 2009 [23]189323868327ELISA40AsianNo
2Cui et al., 2003 [24]64135677210EIA40AsianNo
3Durazo et al., 2008 [25]125141982240ELISA84AsianNo
4Kuromatsu et al., 1997 [26]5867177212ELISA40AsianNo
5Lok et al., 2010 [27]29111066116EIA40CaucasianYes
6Marrero et al., 2003 [28]505599159ELISA125CaucasianNo
7Marrero et al., 2009 [29]310125109292836ELISA150CaucasianNo
8Okuda, 1999 [30]36924108177ELISA40AsianNo
9Sassa et al., 1999 [31]27234132195ECL40AsianYes
10Volk et al., 2007 [17]721212157253ELISA150CaucasianNo
11Wang et al., 2005 [32]4791457127ELISA40AsianNo
12Yoon et al., 2009 [33]5535197206ELISA40AsianNo

TP: true positive; FP: false positive; FN: false negative; TN: true negative.
Small HCC: all tumors were 3 cm in diameter.