Research Article

The Role of e-NOS in Chronic Cholestasis-Induced Liver and Renal Injury in Rats: The Effect of N-Acetyl Cysteine

Figure 3

(a) (Group B) and (b) (Group C): the necrotic area was more intense in Group B than in Group C (H&E, ×200). (c) (Group B): chronic pyelonephritis in Group B with increased fibrosis and tubular hyalinization in tubules (H&E, ×200). (d) (Group B) and (e) (Group C): in Group B, there was increased intertubular inflammation and fibrosis and tubular atrophy (chronic pyelonephritis), but no chronic pyelonephritis was observed in Group C (H&E, ×200). (f) (Group A): weak e-NOS expression in proximal and distal tubular cytoplasm (eNOS, ×200). (g) (Group B) and (h) (Group C): proximal and distal tubular cytoplasmic weak positivity of e-NOS expression was present in Group B and C, but no staining was present in glomeruli (eNOS, ×200). (i) ALT level in three groups for each week postprocedure.
(a)
(b)
(c)
(d)
(e)
(f)
(g)
(h)
(i)