Clinical Study
Adalimumab Treatment in Biologically Naïve Crohn’s Disease: Relationship with Ectopic MUC5AC Expression and Endoscopic Improvement
Table 2
The relation between MUC5AC immunostaining, CDAI, CRP and CDEIS in the CD patients having the ADA treatment as the first TNF-
inhibitor (
).
| | CDAI | CRP | MUC5AC | CDEIS | Clinical course after 52 weeks | 0 w | 12 w | 52 w | 0 w | 12 w | 52 w | 0 w | 12 w | 52 w | 0 w | 12 w | 52 w |
| CD-ADA-1 | Moderate | Remission | Remission | + | − | − | 2 | 2 | 2 | 3+ | 3+ | 3+ | The seton operation was performed, since anal fistula worsened. | CD-ADA-2 | Mild | Remission | Mild | − | − | + | 1 | 0 | 2 | 1+ | 1+ | 3+ | Flare up (CRP = 2.11↑) | CD-ADA-3 | Moderate | Remission | Remission | − | − | + | 1 | 1 | 2 | 2+ | 1+ | 2+ | Flare up (CRP = 6.09↑) after 78 weeks | CD-ADA-4 | Moderate | Mild | Remission | + | − | − | 2 | 2 | 0 | 2+ | 2+ | 1+ | Maintenance of clinical remission | CD-ADA-5 | Mild | Remission | Remission | + | + | + | 2 | 2 | — | 3+ | 1+ | — | Maintenance of clinical remission | CD-ADA-6 | Moderate | Remission | Remission | − | − | − | 2 | 1 | 0 | 3+ | 1+ | MH | Maintenance of clinical remission | CD-ADA-7 | Moderate | Remission | Remission | + | + | − | 2 | 0 | 0 | 3+ | 3+ | 1+ | Maintenance of clinical remission | CD-ADA-8 | Moderate | Remission | Remission | + | + | − | 1 | 0 | 0 | 3+ | MH | MH | Maintenance of clinical remission | CD-ADA-9 | Moderate | Remission | Remission | + | − | − | 1 | 0 | 0 | 3+ | 1+ | 1+ | Maintenance of clinical remission | CD-ADA-10 | Mild | Remission | Remission | + | + | − | 0 | 0 | 0 | 3+ | MH | 2+ | Maintenance of clinical remission | CD-ADA-11 | Mild | Remission | Remission | + | + | + | 0 | 0 | 0 | 3+ | 1+ | 1+ | Maintenance of clinical remission (CRP was judged to be negative after 78 weeks.) | CD-ADA-12 | Moderate | Remission | Remission | − | − | − | 0 | 0 | 0 | 3+ | 1+ | 2+ | Maintenance of clinical remission | CD-ADA-13 | Mild | Remission | Remission | − | − | − | 0 | 0 | 0 | 2+ | 1+ | 1+ | Maintenance of clinical remission | CD-ADA-14 | Moderate | Remission | Remission | + | − | − | 0 | — | 0 | 3+ | — | MH | Maintenance of clinical remission | CD-ADA-15 | Moderate | Remission | Remission | + | − | − | 0 | 0 | 0 | 3+ | MH | MH | Maintenance of clinical remission |
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CDAI: Remission: score < 150; Mild: 150 ≤ score < 220; Moderate: 220 ≤ score < 450; Severe: score ≥ 450. CRP: −: ≤0.30 mg/dL; +: >0.30 mg/dL. CDEIS: non-activity (mucosal healing: MH): CDEIS < 3; mild active stage (1+): 3 ≤ CDEIS < 9; moderate active stage (2+): 9 ≤ CDEIS < 12; severe active stage (3+): 12 ≤ CDEIS.
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