Characteristics of Metachronous Gastric Tumors after Endoscopic Submucosal Dissection for Gastric Intraepithelial Neoplasms

Table 2

Analysis of risk factors for metachronous gastric tumors according to Cox’s proportional hazards model.

Factors	No.	Univariate analysis
		Hazard ratio	95% CI
Age (1-year increment)		1.00	0.97–1.04
Gender
Male	272	1
Female	85	0.36	0.11–0.89
Tumor size (increment of 1 mm)		1.01	0.98–1.03
Location
Upper third	38	1
Middle third	91	1.68	0.55–7.29
Lower third	228	1.02	0.35–4.32
Gross type
Elevated	161	1
Depressed	196	1.07	0.57–2.04
Gastric mucosal atrophy
Closed	30	1
Open	327	1.20	0.43–4.99
Synchronous tumor
Negative	307	1
Positive	50	1.26	0.47–2.79
Histology
Intestinal	331	1
Diffuse	26	0.84	0.20–2.33
Depth
Mucosa	326	1
Submucosa	31	1.05	0.25–2.92
Serum gastrin
≤100 pg/mL	94	1
>100 pg/mL	187	0.58	0.28–1.21
Serum pepsinogen†
Negative	111	1
Positive	170	1.23	0.59–2.75

CI: confidence interval.
†Serum pepsinogen-positive: PG I ≤ 70 ng/mL and PG I/II ≤ 3.