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Gastroenterology Research and Practice
Volume 2014, Article ID 870547, 9 pages
Review Article

Risks of Misinterpretation in the Evaluation of the Effect of Fruit-Based Drinks in Postprandial Studies

1Food and Nutrition Center of the Agricultural Research Council (CRA-NUT), Via Ardeatina 546, 00178 Rome, Italy
2Department of Physiology and Pharmacology “V. Erspamer”, “Sapienza” University of Rome, Piazzale Aldo Moro 5, 00185 Rome, Italy

Received 27 October 2014; Accepted 14 December 2014; Published 25 December 2014

Academic Editor: Gianfranco D. Alpini

Copyright © 2014 Ilaria Peluso and Maura Palmery. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


It has been suggested that some fruit-based drinks (FBD) may delay the onset of postprandial stress, which is involved in the pathogenesis of many diseases. The majority of the studies, which have investigated the effects of FBD on postprandial stress, involved a placebo that was a drink with the same content in sugars or carbohydrates of the FBD, but without the bioactive antioxidant compounds. These studies were aimed more at evaluating the effect of the antioxidants rather than the effect of the FBD as a whole. Only 4 studies compared the effect of FBD with water as control and did not support the hypothesis that FBD could inhibit postprandial dysmetabolism, as well as the studies that compared the effect of orange juice and cola. Overall, the results suggest a complex relationship between postprandial dysmetabolism, inflammation, and oxidative stress. Furthermore, the inflammatory and oxidative stress markers need further analytical validation and normal ranges should be established in order to reach a firm conclusion. Finally, caution should be taken in the interpretation of the effect of FBD in postprandial studies and the reviewed results suggest that dietary recommendations should aim to limit rather than increase sugar-sweetened beverages consumption.