Review Article
Does Preoperative Radio(chemo)therapy Increase Anastomotic Leakage in Rectal Cancer Surgery? A Meta-Analysis of Randomized Controlled Trials
Table 1
Baseline characteristics of studies included in the systematic review.
| Study | Country | Study period | Number of patients | Treatment schedule | Anastomotic leak | R(C)T+ | R(C)T− | R(C)T+ | R(C)T− | R(C)T+ | R(C)T− |
| Cedermark et al., 1995 [18] | Sweden | 1980–1987 | 152 | 153 | 25 Gy, 5 fraction + S | S | 10 | 15 | MRCRCWP, 1996 [19] | England | 1981–1989 | 38 | 38 | 40 Gy, 20 fraction + S | S | 9 | 10 |
Sebag-Montefiore et al., 2009 [20] | Canada | 1998–2005 | 383 | 409 | 25 Gy, 5 fraction + S | S + CT | 32 | 26 | Sauer et al., 2003 [21] | Germany | 1995–2002 | 321 | 342 | 50.4 Gy, 28 fraction + 5-FU + S | S + CT | 39 | 41 | Park et al., 2011 [22] | Korea | 2004–2006 | 84 | 81 | 46 Gy, 23 fraction + CAP + S | S + CT | 4 | 5 | Marijnen et al., 2002 [23] | Netherlands | 1996–1999 | 439 | 465 | 25 Gy, 5 fraction + S | S | 23 | 31 | SRCT [24], 1993 | Sweden | 1987–1990 | 243 | 227 | 25.5 Gy, 5 fraction + S | S | 26 | 17 |
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RT = radiotherapy; CT = chemotherapy; S = surgery; 5-FU = 5-fluorouracil; Capecitabine = CAP.
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