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Gastroenterology Research and Practice
Volume 2015 (2015), Article ID 141070, 17 pages
http://dx.doi.org/10.1155/2015/141070
Review Article

Role of TLR4  rs4986790A>G and rs4986791C>T Polymorphisms in the Risk of Inflammatory Bowel Disease

1Department of Gastroenterology, First Affiliated Hospital of China Medical University, Shenyang 110001, China
2Department of Pathophysiology, College of Basic Medical Sciences, China Medical University, Shenyang 110001, China

Received 16 January 2015; Revised 8 April 2015; Accepted 15 April 2015

Academic Editor: Paolo Gionchetti

Copyright © 2015 Ran Ao et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. N. Pedersen, D. Duricova, M. Elkjaer, M. Gamborg, P. Munkholm, and T. Jess, “Risk of extra-intestinal cancer in inflammatory bowel disease: meta-analysis of population-based cohort studies,” The American Journal of Gastroenterology, vol. 105, no. 7, pp. 1480–1487, 2010. View at Publisher · View at Google Scholar · View at Scopus
  2. P. Lehtinen, M. Ashorn, S. Iltanen et al., “Incidence trends of pediatric inflammatory bowel disease in Finland, 1987–2003, a nationwide study,” Inflammatory Bowel Diseases, vol. 17, no. 8, pp. 1778–1783, 2011. View at Publisher · View at Google Scholar · View at Scopus
  3. C. A. Anderson, G. Boucher, C. W. Lees et al., “Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47,” Nature Genetics, vol. 43, no. 3, pp. 246–252, 2011. View at Google Scholar
  4. M. Dudarewicz, M. Barańska, M. Rychlik-Sych, R. Trzciński, A. Dziki, and J. Skreţkowicz, “C3435T polymorphism of the ABCB1/MDR1 gene encoding P-glycoprotein in patients with inflammatory bowel disease in a Polish population,” Pharmacological Reports, vol. 64, no. 2, pp. 343–350, 2012. View at Publisher · View at Google Scholar · View at Scopus
  5. D. N. Frank, C. E. Robertson, C. M. Hamm et al., “Disease phenotype and genotype are associated with shifts in intestinal-associated microbiota in inflammatory bowel diseases,” Inflammatory Bowel Diseases, vol. 17, no. 1, pp. 179–184, 2011. View at Publisher · View at Google Scholar · View at Scopus
  6. R. Verma, A. K. Verma, V. Ahuja, and J. Paul, “Real-time analysis of mucosal flora in patients with inflammatory bowel disease in India,” Journal of Clinical Microbiology, vol. 48, no. 11, pp. 4279–4282, 2010. View at Publisher · View at Google Scholar · View at Scopus
  7. N. Lévêque, H. Brixi-Benmansour, T. Reig et al., “Low frequency of cytomegalovirus infection during exacerbations of inflammatory bowel diseases,” Journal of Medical Virology, vol. 82, no. 10, pp. 1694–1700, 2010. View at Publisher · View at Google Scholar · View at Scopus
  8. E. Cabré and E. Domènech, “Impact of environmental and dietary factors on the course of inflammatory bowel disease,” World Journal of Gastroenterology, vol. 18, no. 29, pp. 3814–3822, 2012. View at Publisher · View at Google Scholar · View at Scopus
  9. L. Stronati, A. Negroni, M. Pierdomenico et al., “Altered expression of innate immunity genes in different intestinal sites of children with ulcerative colitis,” Digestive and Liver Disease, vol. 42, no. 12, pp. 848–853, 2010. View at Publisher · View at Google Scholar · View at Scopus
  10. G. Sivaram, S. K. Tiwari, A. Bardia et al., “Macrophage migration inhibitory factor, Toll-like receptor 4, and CD14 polymorphisms with altered expression levels in patients with ulcerative colitis,” Human Immunology, vol. 73, no. 2, pp. 201–205, 2012. View at Publisher · View at Google Scholar · View at Scopus
  11. S. T. Qureshi, L. Larivière, G. Leveque et al., “Endotoxin-tolerant mice have mutations in Toll-like receptor 4 (Tlr4),” The Journal of Experimental Medicine, vol. 189, no. 4, pp. 615–625, 1999. View at Publisher · View at Google Scholar
  12. X. Shen, R. Shi, H. Zhang, K. Li, Y. Zhao, and R. Zhang, “The toll-like receptor 4 D299G and T399I polymorphisms are associated with crohn's disease and ulcerative colitis: a meta-analysis,” Digestion, vol. 81, no. 2, pp. 69–77, 2010. View at Publisher · View at Google Scholar · View at Scopus
  13. O. Takeuchi, K. Matsushita, and S. Akira, “Control of inflammatory responses by a novel RNase, Zc3h12a,” Tanpakushitsu Kakusan Koso, vol. 54, no. 14, pp. 1837–1841, 2009. View at Google Scholar
  14. H. Tang, S. Pang, M. Wang et al., “TLR4 activation is required for IL-17-induced multiple tissue inflammation and wasting in mice,” The Journal of Immunology, vol. 185, no. 4, pp. 2563–2569, 2010. View at Publisher · View at Google Scholar · View at Scopus
  15. M. Mohammadi, M. J. Zahedi, A. R. Nikpoor, M. R. Baneshi, and M. M. Hayatbakhsh, “Interleukin-17 serum levels and TLR4 polymorphisms in ulcerative colitis,” Iranian Journal of Immunology, vol. 10, no. 2, pp. 83–92, 2013. View at Google Scholar · View at Scopus
  16. D. C. Baumgart, C. Büning, L. Geerdts et al., “The c.1-260C>T promoter variant of CD14 but not the c.896A>G (p.D299G) variant of toll-like receptor 4 (TLR4) genes is associated with inflammatory bowel disease,” Digestion, vol. 76, no. 3-4, pp. 196–202, 2007. View at Publisher · View at Google Scholar · View at Scopus
  17. M. Ioana, B. Ferwerda, S. Farjadian et al., “High variability of TLR4 gene in different ethnic groups in Iran,” Innate Immunity, vol. 18, no. 3, pp. 492–502, 2012. View at Publisher · View at Google Scholar · View at Scopus
  18. X.-Y. Shen, R.-H. Shi, Y. Wang et al., “Toll-like receptor gene polymorphisms and susceptibility to inflammatory bowel disease in Chinese Han and Caucasian populations,” Zhonghua Yi Xue Za Zhi, vol. 90, no. 20, pp. 1416–1420, 2010. View at Google Scholar · View at Scopus
  19. H. Chen, A. K. Manning, and J. Dupuis, “A method of moments estimator for random effect multivariate meta-analysis,” Biometrics, vol. 68, no. 4, pp. 1278–1284, 2012. View at Publisher · View at Google Scholar · View at MathSciNet · View at Scopus
  20. J. L. Peters, A. J. Sutton, D. R. Jones, K. R. Abrams, and L. Rushton, “Comparison of two methods to detect publication bias in meta-analysis,” Journal of the American Medical Association, vol. 295, no. 6, pp. 676–680, 2006. View at Publisher · View at Google Scholar · View at Scopus
  21. E. Zintzaras and J. P. A. Ioannidis, “Heterogeneity testing in meta-analysis of genome searches,” Genetic Epidemiology, vol. 28, no. 2, pp. 123–137, 2005. View at Publisher · View at Google Scholar · View at Scopus
  22. H. M. Huizenga, I. Visser, and C. V. Dolan, “Testing overall and moderator effects in random effects meta-regression,” British Journal of Mathematical and Statistical Psychology, vol. 64, no. 1, pp. 1–19, 2011. View at Publisher · View at Google Scholar · View at MathSciNet · View at Scopus
  23. D. Jackson, I. R. White, and R. D. Riley, “Quantifying the impact of between-study heterogeneity in multivariate meta-analyses,” Statistics in Medicine, vol. 31, no. 29, pp. 3805–3820, 2012. View at Publisher · View at Google Scholar · View at MathSciNet · View at Scopus
  24. A. M. Ferrenberg and R. H. Swendsen, “New Monte Carlo technique for studying phase transitions,” Physical Review Letters, vol. 61, no. 23, pp. 2635–2638, 1988. View at Publisher · View at Google Scholar · View at Scopus
  25. J. A. C. Sterne and M. Egger, “Funnel plots for detecting bias in meta-analysis: guidelines on choice of axis,” Journal of Clinical Epidemiology, vol. 54, no. 10, pp. 1046–1055, 2001. View at Publisher · View at Google Scholar · View at Scopus
  26. E. A. Wikstrom, S. Naik, N. Lodha, and J. H. Cauraugh, “Balance capabilities after lateral ankle trauma and intervention: a meta-analysis,” Medicine and Science in Sports and Exercise, vol. 41, no. 6, pp. 1287–1295, 2009. View at Publisher · View at Google Scholar · View at Scopus
  27. M. Egger, G. D. Smith, M. Schneider, and C. Minder, “Bias in meta-analysis detected by a simple, graphical test,” British Medical Journal, vol. 315, no. 7109, pp. 629–634, 1997. View at Publisher · View at Google Scholar · View at Scopus
  28. N. K. Meena, R. Verma, N. Verma, V. Ahuja, and J. Paul, “TLR4 D299G polymorphism modulates cytokine expression in ulcerative colitis,” Journal of Clinical Gastroenterology, vol. 47, no. 9, pp. 773–780, 2013. View at Publisher · View at Google Scholar · View at Scopus
  29. D. M. Magalhäes Queiroz, A. Gonçalves Oliveira, I. E. B. Saraiva et al., “Immune response and gene polymorphism profiles in Crohn's disease and ulcerative colitis,” Inflammatory Bowel Diseases, vol. 15, no. 3, pp. 353–358, 2009. View at Publisher · View at Google Scholar · View at Scopus
  30. L. Rigoli, C. Romano, R. A. Caruso et al., “Clinical significance of NOD2/CARD15 and Toll-like receptor 4 gene single nucleotide polymorphisms in inflammatory bowel disease,” World Journal of Gastroenterology, vol. 14, no. 28, pp. 4454–4461, 2008. View at Publisher · View at Google Scholar · View at Scopus
  31. M. Lappalainen, L. Halme, U. Turunen et al., “Association of IL23R, TNFRSF1A, and HLA-DRB1*0103 allele variants with inflammatory bowel disease phenotypes in the Finnish population,” Inflammatory Bowel Diseases, vol. 14, no. 8, pp. 1118–1124, 2008. View at Publisher · View at Google Scholar · View at Scopus
  32. J. Hong, E. Leung, A. G. Fraser, T. R. Merriman, P. Vishnu, and G. W. Krissansen, “TLR2, TLR4 and TLR9 polymorphisms and Crohn's disease in a New Zealand Caucasian cohort,” Journal of Gastroenterology and Hepatology, vol. 22, no. 11, pp. 1760–1766, 2007. View at Publisher · View at Google Scholar · View at Scopus
  33. B. L. Browning, C. Huebner, I. Petermann et al., “Has toll-like receptor 4 been prematurely dismissed as an inflammatory bowel disease gene? Association study combined with meta-analysis shows strong evidence for association,” The American Journal of Gastroenterology, vol. 102, no. 11, pp. 2504–2512, 2007. View at Publisher · View at Google Scholar · View at Scopus
  34. L. E. Oostenbrug, J. P. H. Drenth, D. J. de Jong et al., “Association between Toll-like receptor 4 and inflammatory bowel disease,” Inflammatory Bowel Diseases, vol. 11, no. 6, pp. 567–575, 2005. View at Publisher · View at Google Scholar · View at Scopus
  35. S. Brand, T. Staudinger, F. Schnitzler et al., “The role of Toll-like receptor 4 Asp299Gly and Thr399Ile polymorphisms and CARD15/NOD2 mutations in the susceptibility and phenotype of Crohn's disease,” Inflammatory Bowel Diseases, vol. 11, no. 7, pp. 645–652, 2005. View at Publisher · View at Google Scholar · View at Scopus
  36. H.-P. Török, J. Glas, L. Tonenchi, T. Mussack, and C. Folwaczny, “Polymorphisms of the lipopolysaccharide-signaling complex in inflammatory bowel disease: association of a mutation in the Toll-like receptor 4 gene with ulcerative colitis,” Clinical Immunology, vol. 112, no. 1, pp. 85–91, 2004. View at Publisher · View at Google Scholar · View at Scopus
  37. D. Franchimont, S. Vermeire, H. El Housni et al., “Deficient host-bacteria interactions in inflammatory bowel disease? the toll-like receptor (TLR)-4 Asp299gly polymorphism is associated with Crohn's disease and ulcerative colitis,” Gut, vol. 53, no. 7, pp. 987–992, 2004. View at Publisher · View at Google Scholar · View at Scopus
  38. N. J. Gay and M. Gangloff, “Structure and function of toll receptors and their ligands,” Annual Review of Biochemistry, vol. 76, pp. 141–145, 2007. View at Publisher · View at Google Scholar · View at Scopus
  39. A. G. Kutikhin, “Impact of Toll-like receptor 4 polymorphisms on risk of cancer,” Human Immunology, vol. 72, no. 2, pp. 193–206, 2011. View at Publisher · View at Google Scholar · View at Scopus
  40. C. E. Sawian, S. D. Lourembam, A. Banerjee, and S. Baruah, “Polymorphisms and expression of TLR4 and 9 in malaria in two ethnic groups of Assam, northeast India,” Innate Immunity, vol. 19, no. 2, pp. 174–183, 2013. View at Publisher · View at Google Scholar · View at Scopus
  41. H. M. Kim, B. S. Park, J.-I. Kim et al., “Crystal structure of the TLR4-MD-2 complex with bound endotoxin antagonist Eritoran,” Cell, vol. 130, no. 5, pp. 906–917, 2007. View at Publisher · View at Google Scholar · View at Scopus
  42. J. D. Rioux, R. J. Xavier, K. D. Taylor et al., “Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis,” Nature Genetics, vol. 39, no. 5, pp. 596–604, 2007. View at Publisher · View at Google Scholar · View at Scopus