The Frequent Adiponutrin (PNPLA3) Variant p.Ile148Met Is Associated with Early Liver Injury: Analysis of a German Pediatric Cohort
Table 2
Metabolic traits in relation to the PNPLA3 p.Ile148Met genotypes.
Feature
PNPLA3 p.Ile148Met genotype
value
Ile/Ile ( = 75)
Ile/Met ( = 57)
Met/Met ( = 10)
Triglycerides (mg/dL)
70.0 (25.0–294.0)
69.0 (35.0–231.0)
57.5 (41.0–92.0)
0.39
HDL cholesterol (mg/dL)
54.0 (26.0–71.0)
52.0 (21.0–77.0)
50.5 (38.0–64.0)
0.55
LDL cholesterol (mg/dL)
108.0 (63.0–155.0)
114.0 (62.0–166.0)
99.5 (93.0–124.0)
0.09
Total cholesterol (mg/dL)
176.0 (113.0–230.0)
185.0 (121.0–245.0)
164.5 (145.0–187.0)
0.06
Glucose (mg/dL)
84.5 (72.0–103.0)
87.0 (63.0–122.0)
84.5 (75.0–94.0)
0.01
Insulin (µlU/mL)
10.0 (4.1–38.8)
11.0 (1.9–33.7)
8.4 (2.8–17.0)
0.06
IR-HOMA
2.0 (1.0–9.2)
2.6 (0.5–7.7)
1.6 (0.6–3.6)
0.02
Ile: isoleucine; IR-HOMA: insulin resistance homeostasis model assessment; Met: methionine; p: protein (amino acid number); PNPLA3: adiponutrin. Values are given as medians and ranges.
