Immunohistochemical Expression of Dual-Specificity Protein Phosphatase 4 in Patients with Colorectal Adenocarcinoma

Table 3

Effect of variables on overall survival and disease-free survival in colorectal adenocarcinomas ( = 439).

Variables	Univariable analysis^†		Multivariable analysis^†
	HR (95% CI)	value	HR (95% CI)	value
Overall survival
DUSP4 expression (negative versus positive)	1.317 (0.956–1.816)	0.092	1.156 (0.833–1.604)	0.386
Patient age (<58 yrs versus ≥58 yrs)	1.856 (1.373–2.508)	<0.001	1.694 (1.216–2.360)	0.002
Differentiation (low versus high)	2.391 (1.757–3.253)	<0.001	1.678 (1.183–2.381)	0.004
AJCC stage (0, I, II versus III, IV)	3.062 (2.180–4.300)	<0.001	2.729 (1.873–3.977)	<0.001
Vascular invasion (absent versus present)	3.326 (1.561–7.090)	0.002	3.058 (1.422–6.574)	0.004
Disease-free survival
DUSP4 expression (negative versus positive)	1.268 (0.955–1.685)	0.101	1.147 (0.859–1.533)	0.352
Patient age (<58 yrs versus ≥58 yrs)	1.491 (1.150–1.934)	0.003	1.363 (1.022–1.816)	0.035
Differentiation (low versus high)	2.115 (1.598–2.798)	<0.001	1.527 (1.113–2.095)	0.009
AJCC stage (0, I, II versus III, IV)	3.287 (2.442–4.425)	<0.001	3.122 (2.236–4.360)	<0.001
Vascular invasion (absent versus present)	2.512 (1.183–5.334)	0.016	2.280 (1.066–4.879)	0.034

Cox proportional hazards model.
HR: hazard ratio; CI: confidence interval; DUSP4: dual specificity protein phosphatase 4; AJCC: American Joint Committee on Cancer.