Table of Contents Author Guidelines Submit a Manuscript
Gastroenterology Research and Practice
Volume 2015 (2015), Article ID 327872, 9 pages
http://dx.doi.org/10.1155/2015/327872
Research Article

Herbal Substance, Acteoside, Alleviates Intestinal Mucositis in Mice

1Gastroenterology Unit, Women’s & Children’s Health Network, 72 King William Road, North Adelaide, SA 5006, Australia
2Discipline of Physiology, School of Medical Sciences, University of Adelaide, Adelaide, SA 5005, Australia
3Department of Pharmacognosy & Natural Products Chemistry, National and Kapodistrian University of Athens, 15771 Ilisia, Greece

Received 21 October 2014; Revised 4 December 2014; Accepted 4 December 2014

Academic Editor: Gianfranco D. Alpini

Copyright © 2015 Daniel Reinke et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. J.-L. Pico, A. Avila-Garavito, and P. Naccache, “Mucositis: its occurrence, consequences, and treatment in the oncology setting,” Oncologist, vol. 3, no. 6, pp. 446–451, 1998. View at Google Scholar · View at Scopus
  2. S. T. Sonis and K. A. Costello, “A database for mucositis induced by cancer chemotherapy,” European Journal of Cancer—Part B: Oral Oncology, vol. 31, no. 4, pp. 258–260, 1995. View at Publisher · View at Google Scholar · View at Scopus
  3. B. A. E. de Koning, J. M. van Dieren, D. J. Lindenbergh-Kortleve et al., “Contributions of mucosal immune cells to methotrexate-induced mucositis,” International Immunology, vol. 18, no. 6, pp. 941–949, 2006. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  4. S. T. Sonis, “Mucositis: the impact, biology and therapeutic opportunities of oral mucositis,” Oral Oncology, vol. 45, no. 12, pp. 1015–1020, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  5. R. M. Logan, A. M. Stringer, J. M. Bowen et al., “The role of pro-inflammatory cytokines in cancer treatment-induced alimentary tract mucositis: pathobiology, animal models and cytotoxic drugs,” Cancer Treatment Reviews, vol. 33, no. 5, pp. 448–460, 2007. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  6. N. Boukhettala, J. Leblond, S. Claeyssens et al., “Methotrexate induces intestinal mucositis and alters gut protein metabolism independently of reduced food intake,” The American Journal of Physiology: Endocrinology and Metabolism, vol. 296, no. 1, pp. E182–E190, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  7. M. R. Posner and R. I. Haddad, “Novel agents for the treatment of mucositis,” Journal of Supportive Oncology, vol. 5, no. 9, pp. 33–39, 2007. View at Google Scholar · View at Scopus
  8. E. B. Rubenstein, D. E. Peterson, M. Schubert et al., “Clinical practice guidelines for the prevention and treatment of cancer therapy-induced oral and gastrointestinal mucositis,” Cancer, vol. 100, no. S9, pp. 2026–2046, 2004. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  9. D. M. Keefe, S. T. Sonis, and J. M. Bowen, “Emerging drugs for chemotherapy-induced mucositis,” Expert Opinion on Emerging Drugs, vol. 13, no. 3, pp. 511–522, 2008. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  10. D. M. Keefe, M. M. Schubert, L. S. Elting et al., “Updated clinical practice guidelines for the prevention and treatment of mucositis,” Cancer, vol. 109, no. 5, pp. 820–831, 2007. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  11. L. Negri, R. Lattanzi, E. Giannini et al., “Impaired nociception and inflammatory pain sensation in mice lacking the prokineticin receptor PKR1: focus on interaction between PKR1 and the capsaicin receptor TRPV1 in pain behavior,” The Journal of Neuroscience, vol. 26, no. 25, pp. 6716–6727, 2006. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  12. T. H. Wright, R. Yazbeck, K. A. Lymn et al., “The herbal extract, Iberogast, improves jejunal integrity in rats with 5-Fluorouracil (5-FU)-induced mucositis,” Cancer Biology and Therapy, vol. 8, no. 10, pp. 923–929, 2009. View at Publisher · View at Google Scholar · View at Scopus
  13. W. T. Y. Loo, L. Jin, L. W. C. Chow, M. N. B. Cheung, and M. Wang, “Rhodiola algida improves chemotherapy-induced oral mucositis in breast cancer patients,” Expert Opinion on Investigational Drugs, vol. 19, no. 1, pp. S91–S100, 2010. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  14. A. M. Díaz, M. J. Abad, L. Fernández, A. M. Silván, J. de Santos, and P. Bermejo, “Phenylpropanoid glycosides from Scrophularia scorodonia: in vitro anti-inflammatory activity,” Life Sciences, vol. 74, no. 20, pp. 2515–2526, 2004. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  15. B. Konuklugil and Ö. Bahadir, “Phenylpropanoid glycosides from Linum olympicum,” Turkish Journal of Chemistry, vol. 28, no. 6, pp. 741–744, 2004. View at Google Scholar · View at Scopus
  16. Y. P. Hwang, H. G. Kim, J. H. Choi et al., “Acteoside inhibits PMA-induced matrix metalloproteinase-9 expression via CaMK/ERK- and JNK/NF-κB-dependent signaling,” Molecular Nutrition & Food Research, vol. 55, supplement 1, pp. S103–S116, 2011. View at Publisher · View at Google Scholar · View at PubMed
  17. A. Güvenç, Y. Okada, E. K. Akkol, H. Duman, T. Okuyama, and I. Çaliş, “Investigations of anti-inflammatory, antinociceptive, antioxidant and aldose reductase inhibitory activities of phenolic compounds from Sideritis brevibracteata,” Food Chemistry, vol. 118, no. 3, pp. 686–692, 2010. View at Publisher · View at Google Scholar · View at Scopus
  18. M. Hausmann, F. Obermeier, D. H. Paper et al., “In vivo treatment with the herbal phenylethanoid acteoside ameliorates intestinal inflammation in dextran sulphate sodium-induced colitis,” Clinical and Experimental Immunology, vol. 148, no. 2, pp. 373–381, 2007. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  19. Q. Xiong, K. Hase, Y. Tezuka, T. Namba, and S. Kadota, “Acteoside inhibits apoptosis in D-Galactosamine and lipopolysaccharide- induced liver injury,” Life Sciences, vol. 65, no. 4, pp. 421–430, 1999. View at Publisher · View at Google Scholar · View at Scopus
  20. T. Genovese, I. Paterniti, E. Mazzon et al., “Efficacy of treatment with verbascoside, biotechnologically produced by Syringa vulgaris plant cell cultures in an experimental mice model of spinal cord trauma,” Naunyn-Schmiedeberg's Archives of Pharmacology, vol. 382, no. 4, pp. 331–345, 2010. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  21. J. Y. Lee, E.-R. Woo, and K. W. Kang, “Inhibition of lipopolysaccharide-inducible nitric oxide synthase expression by acteoside through blocking of AP-1 activation,” Journal of Ethnopharmacology, vol. 97, no. 3, pp. 561–566, 2005. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  22. C. D. Tran, S. Sundar, and G. S. Howarth, “Dietary zinc supplementation and methotrexate-induced small intestinal mucositis in metallothionein-knockout and wild-type mice,” Cancer Biology and Therapy, vol. 8, no. 17, pp. 1662–1667, 2009. View at Publisher · View at Google Scholar · View at Scopus
  23. A. Dahlqvist, “Method for assay of intestinal disaccharidases,” Analytical Biochemistry, vol. 7, no. 1, pp. 18–25, 1964. View at Publisher · View at Google Scholar · View at Scopus
  24. D. L. Eaton and B. F. Toal, “Evaluation of the Cd/hemoglobin affinity assay for the rapid determination of metallothionein in biologival tissues,” Toxicology and Applied Pharmacology, vol. 66, no. 1, pp. 134–142, 1982. View at Publisher · View at Google Scholar · View at Scopus
  25. G. S. Howarth, G. L. Francis, J. C. Cool, X. Xu, R. W. Byard, and L. C. Read, “Milk growth factors enriched from cheese whey ameliorate intestinal damage by methotrexate when administered orally to rats,” The Journal of Nutrition, vol. 126, no. 10, pp. 2519–2530, 1996. View at Google Scholar · View at Scopus
  26. R. Medeiros, R. D. S. Prediger, G. F. Passos et al., “Connecting TNF-α signaling pathways to iNOS expression in a mouse model of Alzheimer's disease: relevance for the behavioral and synaptic deficits induced by amyloid β protein,” Journal of Neuroscience, vol. 27, no. 20, pp. 5394–5404, 2007. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  27. D. M. Templeton and M. G. Cherian, “Toxicological significance of metallothionein,” Methods in Enzymology, vol. 205, pp. 11–24, 1991. View at Publisher · View at Google Scholar · View at Scopus
  28. J. Abel and N. de Ruiter, “Inhibition of hydroxyl-radical-generated DNA degradation by metallothionein,” Toxicology Letters, vol. 47, no. 2, pp. 191–196, 1989. View at Publisher · View at Google Scholar · View at Scopus
  29. M. Fotin-Mleczek, F. Henkler, A. Hausser et al., “Tumor necrosis factor receptor-associated factor (TRAF) 1 regulates CD40-induced TRAF2-mediated NF-κB activation,” The Journal of Biological Chemistry, vol. 279, no. 1, pp. 677–685, 2004. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  30. K. Hayashi, T. Nagamatsu, M. Ito, H. Yagita, and Y. Suzuki, “Acteoside, a component of Stachys sieboldii MIQ, may be a promising antinephritic agent (3): effect of acteoside on expression of intercellular adhesion molecule-1 in experimental nephritic glomeruli in rats and cultured endothelial cells,” The Japanese Journal of Pharmacology, vol. 70, no. 2, pp. 157–168, 1996. View at Publisher · View at Google Scholar · View at Scopus
  31. Q. Xiong, Y. Tezuka, T. Kaneko et al., “Inhibition of nitric oxide by phenylethanoids in activated macrophages,” European Journal of Pharmacology, vol. 400, no. 1, pp. 137–144, 2000. View at Publisher · View at Google Scholar · View at Scopus
  32. L. Speranza, S. Franceschelli, M. Pesce et al., “Antiinflammatory effects in THP-1 cells treated with verbascoside,” Phytotherapy Research, vol. 24, no. 9, pp. 1398–1404, 2010. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  33. Y. Al-Gindan, M. Shawarby, A. Noto, and C. G. Taylor, “Intestinal inflammation in rats induces metallothionein in colonic submucosa,” Journal of Clinical Biochemistry and Nutrition, vol. 44, no. 2, pp. 131–141, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  34. M. Brüwer, K. W. Schmid, K. A. Metz, C. F. Krieglstein, N. Senninger, and G. Schürmann, “Increased expression of metallothionein in inflammatory bowel disease,” Inflammation Research, vol. 50, no. 6, pp. 289–293, 2001. View at Publisher · View at Google Scholar · View at Scopus