Assessing the Effect of Leptin on Liver Damage in Case of Hepatic Injury Associated with Paracetamol Poisoning

Table 3

The GSH and MDA levels measured in the rat liver tissues.

Group	GSH (nmol/mg protein)	MDA (nmol/mg protein)
Control	3.84 ± 0.79^c	1.37 ± 0.23^a
LEP 20 µg/kg	3.33 ± 0.72^b.c	1.29 ± 0.76^a
PARA 2 g/kg	1.74 ± 0.55^a	4.04 ± 1.50^b
PARA 2 g/kg + LEP 10 µg/kg	3.35 ± 0.71^b.c	1.40 ± 0.78^a
PARA 2 g/kg + LEP 20 µg/kg	2.81 ± 0.66^b	1.91 ± 0.40^a

Group 1: the control group; Group 2: 20 µg/kg leptin; Group 3: 2 g/kg paracetamol; Group 4: 2 g/kg paracetamol + 10 µg/kg leptin; Group 5: 2 g/kg paracetamol + 20 µg/kg leptin. Malondialdehyde (MDA) levels and the Glutathione (GSH). LEP: the group receiving leptin, PARA: the group receiving paracetamol. The results were analyzed using the post hoc Duncan technique in the one-way ANOVA test. comparison of the control group and paracetamol group, comparison of the control group and treatment group, and comparison of the paracetamol group and the treatment group. was considered significant.