Impact of the Siewert Classification on the Outcome of Patients Treated by Preoperative Chemoradiotherapy for a Nonmetastatic Adenocarcinoma of the Oesophagogastric Junction
Table 4
Uni- and multivariate analysis for overall survival (a) and overall relapse rate (b).
(a)
Univariate analysis
Multivariate analysis
Alive (%)
HR [CI 95%](2)
No
Yes
Total ()
42 (62)
26 (38)
—
—
—
pT
ypT0/T1/T2
22 (55%)
18 (45%)
0.073
1
0.6
ypT3/T4
16 (76%)
5 (24%)
1.2 [0.5–2.7]
pN
ypN0
13 (39%)
20 (61%)
<0.0001
1
—
ypN0+
26 (87%)
4 (13%)
4.1 [1.83–9.2]
0.001
Siewert classification
Siewert 1
6 (40%)
9 (60%)
0.14
1
—
Siewert 2/3
34 (68%)
16 (32%)
1.5 [0.6–3.7]
0.4
Performance status
PS 0-1
20 (38%)
33 (62%)
0.05
1
0.7
PS 2-3
2 (25%)
6 (75%)
1.2 [0.4–3.9]
(b)
Univariate analysis
Multivariate analysis
Relapse (%)
HR (CI 95%)(2)
No
Yes
Total
36 (53)
32 (47)
—
—
—
ypT
ypT0/T1/T2
24 (60%)
16 (40%)
0.13
1
—
ypT3/T4
73 (90%)
8 (10%)
1.2 [0.5–2.8]
0.6
ypN
ypN0
23 (70%)
10 (30%)
0.003
1
—
ypN0+
12 (40%)
18 (60%)
3.4 [1.4–8.1]
0.005
Age (years)
≤62
14 (39%)
22 (61%)
0.038
1
—
>62
22 (69%)
10 (31%)
0.36 [0.15–0.86]
0.02
Siewert classification
Siewert 1
12 (80%)
3 (20%)
0.047
1
—
Siewert 2/3
23 (46%)
27 (54%)
2.8 [0.8–9.5]
0.1
value” of Log-rank test. (2)Hazard-Ratio (95% confidence interval). value” of Cox model.
