Bufalin Inhibits HCT116 Colon Cancer Cells and Its Orthotopic Xenograft Tumor in Mice Model through Genes Related to Apoptotic and PTEN/AKT Pathways

Figure 4

Effect of Bufalin on tumor volume, animal survival, and apoptosis. Bufalin treatment significantly inhibited tumor growth compared to the control group () (a), prolonged survival time () (b), and increased apoptosis in tumor (c). Groups: A: control, B: 5-FU, C: 0.5 mg/kg Bufalin, D: 1.0 mg/kg Bufalin, and E: 1.5 mg/kg Bufalin.

(a)

(b)

(c)