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Gastroenterology Research and Practice
Volume 2015, Article ID 518281, 9 pages
http://dx.doi.org/10.1155/2015/518281
Review Article

Understanding Complete Pathologic Response in Oesophageal Cancer: Implications for Management and Survival

The Mater Private Hospital, Eccles Street, Dublin, Ireland

Received 24 March 2015; Revised 28 May 2015; Accepted 25 June 2015

Academic Editor: Dimitris S. Ladas

Copyright © 2015 K. E. O’Sullivan et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Despite significant improvement over recent decades, oesophageal cancer survival rates remain poor. Neoadjuvant chemoradiotherapy followed by oesophageal resection is mainstay of therapy for resectable oesophageal tumours. Operative morbidity and mortality associated with oesophagectomy remain high and complications arise in up to 60% of patients. Management strategies have moved towards definitive chemoradiotherapy for a number of tumour sites (head and neck, cervical, and rectal) particularly for squamous pathology. We undertook to perform a review of the current status of morbidity and mortality associated with oesophagectomy, grading systems determining pathologic response, and data from clinical trials managing patients with definitive chemoradiotherapy to inform a discussion on the topic.