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Gastroenterology Research and Practice
Volume 2015, Article ID 532615, 7 pages
http://dx.doi.org/10.1155/2015/532615
Research Article

Proinflammatory Cytokines (IL-1α, IL-6) and Hepatocyte Growth Factor in Patients with Alcoholic Liver Cirrhosis

1Department of Internal Medicine, Medical University of Lublin, Staszica 16, 20-081 Lublin, Poland
2Department of Family Medicine, Medical University of Lublin, Staszica 11, 20-081 Lublin, Poland
3Department of Ethics and Human Philosophy, Medical University of Lublin, Staszica 4/6, 20-059 Lublin, Poland
4Department of Nephrology, Medical University of Lublin, Jaczewskiego 8, 20-954 Lublin, Poland
5Department of Medical Chemistry, Medical University of Lublin, Chodźki 4a, 20-093 Lublin, Poland
6Department of Mathematics and Medical Biostatistics, Medical University of Lublin, Jaczewskiego 4, 20-954 Lublin, Poland

Received 9 June 2015; Accepted 6 August 2015

Academic Editor: Eddie K. Abdalla

Copyright © 2015 Andrzej Prystupa et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Background. The aim of the study was to assess the activity of interleukin-1α, interleukin-6, and hepatocyte growth factor protein (HGF) in serum of patients with alcoholic liver cirrhosis. Materials and Methods. Sixty patients with alcoholic liver cirrhosis treated in various hospitals were randomly enrolled. The stage of cirrhosis was assessed according to the Child-Turcotte-Pugh scoring system. The control group consisted of ten healthy persons without liver disease, who did not drink alcohol. Additionally, the group of alcoholics without liver cirrhosis was included in the study. The activity of interleukin-1α, interleukin-6, and HGF in blood plasma of patients and controls was measured using the sandwich enzyme immunoassay technique with commercially available quantitative ELISA test kits. Results. Higher concentrations of HGF protein were demonstrated in patients with Child class B and Child class C liver cirrhosis, compared to controls and alcoholics without liver cirrhosis. Moreover, significantly higher concentrations of HGF protein were found in patients with Child class C liver cirrhosis compared to patients with Child class A liver cirrhosis . The concentrations of interleukin-1α in patients with Child class B and Child class C liver cirrhosis were significantly higher in comparison with controls. Significantly higher concentrations of interleukin-6 were demonstrated in Child class C, compared to Child class A.