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Gastroenterology Research and Practice
Volume 2015, Article ID 650846, 9 pages
Review Article

Adjuvant Chemoradiation Therapy in Gastric Cancer: Critically Reviewing the Past and Visualizing the Next Step Forward

1Department of Medical Oncology, University of Antwerp, 2650 Antwerp, Belgium
2Department of Medical Oncology, Royal Marsden Hospital NHS Foundation Trust, London SW3 6JJ, UK
3Department of Surgical and Oncology Sciences, University of Palermo, 90127 Palermo, Italy
4Department of Radiation Oncology, B.O.C. Oncology Centre, 2006 Nicosia, Cyprus
5Department of Medical Oncology, B.O.C. Oncology Centre, 2006 Nicosia, Cyprus

Received 9 March 2015; Revised 10 May 2015; Accepted 12 May 2015

Academic Editor: Vikram Kate

Copyright © 2015 Konstantinos Papadimitriou et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Gastric cancer remains one of the most common malignancies worldwide. Despite the significant advances in surgical treatment and multimodality strategies, prognosis has modestly improved over the last two decades. Locoregional relapse remains one of the main issues and the combined chemoradiation treatment seems to be one of the preferred approaches. However, more than ten years after the hallmark INT-0116 trial, minimal progress has been made both in terms of effectiveness and toxicity. Moreover, new regimens added to combined therapy failed to prove favourable results. Herein, we attempt a thorough literature review comparing pros and cons of all relative studies and potential bias, targeting well-designed future approaches.