Analysis of the Serum Bile Acid Composition for Differential Diagnosis in Patients with Liver Disease
Table 3
The serum bile acid compositions among the patients with different liver diseases.
(μM)
Viral hepatitis (HBV + HCV)
ALD
Biliary tract disease
NAFLD
Other liver diseases
Healthy controls
67
21
20
13
29
46
CA
0.0851 (0.0560, 0.1293)
0.1303 (0.0564, 0.3008)
0.0695 (0.0331, 0.1459)
0.1867 (0.0700, 0.4978)
0.0821 (0.0439, 0.1533)
0.0638 (0.0129, 0.9090)
GCA
0.8171 (0.5323, 1.2543)
0.9344 (0.3964, 2.2028)
1.9652 (0.9196, 4.2000)
0.6518 (0.2387, 1.7800)
1.4384 (0.7584, 2.7280)
0.1235 (0.0206, 2.7400)
TCA
0.2289 (0.1368, 0.3828)
0.1952 (0.0697, 0.5462)
0.6900 (0.2774, 1.7164)*
0.1147 (0.0344, 0.3830)
0.4915 (0.2280, 1.0594)
0.0157 (0.0016, 0.9240)
CDCA
0.2539 (0.1640, 0.3931)
0.5525 (0.2304, 1.3251)
0.1047 (0.0483, 0.2272)
0.5511 (0.1978, 1.5357)
0.1578 (0.0821, 0.3032)
0.3445 (0.0294, 2.3400)
GCDCA
2.8356 (2.0016, 4.0171)
3.7629 (1.8744, 7.5538)
4.9012 (2.6441, 9.0851)
2.6327 (1.1638, 5.9558)
3.3493 (1.9911, 5.6341)
0.5460 (0.1130, 4.3400)
TCDCA
0.8308 (0.5354, 1.2891)
0.7649 (0.3176, 1.8421)
1.9965 (0.9167, 4.3483)
0.3995 (0.1427, 1.1186)
1.1573 (0.6006, 2.2301)
0.1095 (0.0177, 1.1900)
DCA
0.1290 (0.0791, 0.2105)
0.0788 (0.0296, 0.2096)
0.0322 (0.0135, 0.0766)**
0.1984 (0.0630, 0.6245)
0.0736 (0.0355, 0.1528)
0.2665 (0.0000, 0.7360)
GDCA
0.2320 (0.1334, 0.4033)
0.1449 (0.0479, 0.4382)
0.1782 (0.0669, 0.4748)
0.2530 (0.0692, 0.9250)
0.1786 (0.0782, 0.4080)
0.1570 (0.0000, 1.8200)
TDCA
0.0767 (0.0499, 0.1181)
0.0390 (0.0165, 0.0924)
0.0900 (0.0419, 0.1933)
0.0627 (0.0228, 0.1722)
0.0635 (0.0334, 0.1209)
0.0219 (0.0000, 0.3980)
LCA
0.0242 (0.0184, 0.0318)
0.0220 (0.0127, 0.0381)
0.0177 (0.0109, 0.0289)
0.0346 (0.0182, 0.0659)
0.0178 (0.0118, 0.0269)
0.0103 (0.0000, 0.0291)
GLCA
0.0233 (0.0173, 0.0313)
0.0142 (0.0079, 0.0256)
0.0150 (0.0089, 0.0253)
0.0276 (0.0138, 0.0550)
0.0229 (0.0147, 0.0355)
0.0071 (0.0000, 0.0338)
TLCA
0.0145 (0.0105, 0.0200)
0.0109 (0.0057, 0.0207)
0.0176 (0.0100, 0.0311)
0.0095 (0.0045, 0.0201)
0.0140 (0.0087, 0.0226)
0.0057 (0.0000, 0.0231)
UDCA
0.2369 (0.1539, 0.3645)
1.1532 (0.4868, 2.7321)**
0.0884 (0.0412, 0.1897)*
0.3263 (0.1188, 0.8962)
0.2254 (0.1184, 0.4290)
0.1975 (0.0000, 0.6030)
GUDCA
0.8998 (0.5728, 1.4134)
3.3367 (1.3518, 8.2361)*
0.7939 (0.3567, 1.7672)
0.7276 (0.2525, 2.0970)
1.0877 (0.5542, 2.1349)
0.2110 (0.0145, 1.4200)
TUDCA
0.1076 (0.0659, 0.1756)
0.2419 (0.0908, 0.6450)
0.1281 (0.0537, 0.3052)
0.0553 (0.0175, 0.1745)
0.1516 (0.0729, 0.3151)
0.0085 (0.0000, 0.1510)
12-KLCA
0.0561 (0.0436, 0.0723)
0.0397 (0.0239, 0.0657)
0.0355 (0.0227, 0.0555)
0.0604 (0.0334, 0.1092)
0.0322 (0.0221, 0.0469)
0.0101 (0.0000, 0.0943)
Cumulative total bile acid
6.8515
11.4215
11.1237
6.2919
8.5437
2.0986
The values in patients with liver disease are the least square geometric mean concentrations with 95% CI. The values in healthy controls are the median with 2.5% point and 97.5% point. < 0.01 and < 0.05 versus viral hepatitis in patients with liver disease.
