Analysis of the Serum Bile Acid Composition for Differential Diagnosis in Patients with Liver Disease
Table 4
(a) The results of a comparison of the serum bile acids among different etiologies of liver diseases in patients with UDCA treatment. (b) The results of a comparison of the serum bile acids among different etiologies of liver diseases in patients without UDCA treatment.
(a)
(μM)
Viral hepatitis (HBV + HCV)
ALD
Biliary tract disease
NAFLD
Other liver diseases
Healthy controls
40
9
5
3
11
46
CA
0.0788 (0.0440, 0.1413)
0.1851 (0.0462, 0.7409)
0.1414 (0.0276, 0.7236)
1.2708 (0.1102, 14.649)*
0.2271 (0.0745, 0.6921)
0.0638 (0.0129, 0.9090)
GCA
0.5557 (0.3718, 0.8306)
2.5674 (0.9881, 6.6709)**
3.4416 (1.1186, 10.589)**
3.8566 (0.7168, 20.750)*
1.0244 (0.4757, 2.2061)
0.1235 (0.0206, 2.7400)
TCA
0.1479 (0.0873, 0.2503)
0.7570 (0.2167, 2.6445)
1.0705 (0.2456, 4.6665)*
0.7062 (0.0779, 6.4018)
0.2248 (0.0823, 0.6141)
0.0157 (0.0016, 0.9240)
CDCA
0.3485 (0.1975, 0.6151)
0.5274 (0.1368, 2.0341)
0.3220 (0.0658, 1.5771)
3.7919 (0.3514, 40.922)
0.7003 (0.2368, 2.0715)
0.3445 (0.0294, 2.3400)
GCDCA
2.4618 (1.7090, 3.5462)
8.1448 (3.4220, 19.386)*
10.005 (3.6055, 27.763)*
13.048 (2.8304, 60.149)*
3.6051 (1.7962, 7.2358)
0.5460 (0.1130, 4.3400)
TCDCA
0.6805 (0.4143, 1.1177)
2.4085 (0.7408, 7.8300)
4.1830 (1.0444, 16.754)*
2.0567 (0.2575, 16.426)
0.7495 (0.2907, 1.9326)
0.1095 (0.0177, 1.1900)
DCA
0.1406 (0.0736, 0.2686)
0.0804 (0.0173, 0.3742)
0.0356 (0.0058, 0.2174)
0.0830 (0.0055, 1.2468)
0.1628 (0.0473, 0.5600)
0.2665 (0.0000, 0.7360)
GDCA
0.2278 (0.1124, 0.4618)
0.1826 (0.0341, 0.9781)
0.0482 (0.0067, 0.3474)
0.1359 (0.0071, 2.6181)
0.2567 (0.0666, 0.9888)
0.1570 (0.0000, 1.8200)
TDCA
0.0624 (0.0355, 0.1099)
0.0620 (0.0162, 0.2376)
0.0509 (0.0105, 0.2472)
0.0599 (0.0056, 0.6386)
0.0411 (0.0140, 0.1209)
0.0219 (0.0000, 0.3980)
LCA
0.0275 (0.0186, 0.0408)
0.0283 (0.0111, 0.0719)
0.0165 (0.0055, 0.0494)
0.0520 (0.0101, 0.2688)
0.0392 (0.0185, 0.0829)
0.0103 (0.0000, 0.0291)
GLCA
0.0252 (0.0159, 0.0401)
0.0219 (0.0073, 0.0657)
0.0293 (0.0080, 0.1069)
0.0305 (0.0044, 0.2114)
0.0299 (0.0124, 0.0723)
0.0071 (0.0000, 0.0338)
TLCA
0.0149 (0.0098, 0.0228)
0.0198 (0.0073, 0.0541)
0.0213 (0.0065, 0.0694)
0.0078 (0.0013, 0.0455)
0.0099 (0.0044, 0.0221)
0.0057 (0.0000, 0.0231)
UDCA
1.5203 (0.8882, 2.6022)
5.1120 (1.4256, 18.330)
0.8803 (0.1958, 3.9572)
1.2878 (0.1357, 12.224)
2.6510 (0.9503, 7.3956)
0.1975 (0.0000, 0.6030)
GUDCA
4.2367 (2.6009, 6.9014)
21.824 (6.8462, 69.568)*
9.8971 (2.5289, 38.734)
5.9534 (0.7717, 45.926)
6.1963 (2.4413, 15.727)
0.2110 (0.0145, 1.4200)
TUDCA
0.4544 (0.2526, 0.8173)
2.4936 (0.6179, 10.063)*
1.4632 (0.2833, 7.5587)
0.2802 (0.0240, 3.2756)
0.4095 (0.1335, 1.2561)
0.0085 (0.0000, 0.1510)
12-KLCA
0.0707 (0.0469, 0.1067)
0.0319 (0.0120, 0.0846)
0.0796 (0.0252, 0.2511)
0.1449 (0.0259, 0.8101)
0.0469 (0.0214, 0.1029)
0.0101 (0.0000, 0.0943)
The values in patients with liver disease are the least square geometric mean concentrations with 95% CI. The values in healthy controls are the median with 2.5% point and 97.5% point. < 0.01 and < 0.05 versus viral hepatitis in patients with liver disease.
(b)
(μM)
Viral hepatitis (HBV + HCV)
ALD
Biliary tract disease
NAFLD
Other liver diseases
Healthy controls
27
12
15
10
18
46
CA
0.1038 (0.0536, 0.2008)
0.1134 (0.0328, 0.3918)
0.0461 (0.0201, 0.1055)
0.1123 (0.0384, 0.3284)
0.0398 (0.0187, 0.0844)
0.0638 (0.0129, 0.9090)
GCA
1.2768 (0.5390, 3.0246)
0.4700 (0.0930, 2.3740)
1.6582 (0.5622, 4.8914)
0.5272 (0.1297, 2.1427)
1.6791 (0.6277, 4.4916)
0.1235 (0.0206, 2.7400)
TCA
0.4047 (0.1493, 1.0971)
0.0527 (0.0081, 0.3428)
0.6966 (0.1994, 2.4335)
0.1199 (0.0237, 0.6067)
0.6846 (0.2194, 2.1360)
0.0157 (0.0016, 0.9240)
CDCA
0.1874 (0.0898, 0.3912)
0.8048 (0.2020, 3.2062)
0.0532 (0.0211, 0.1339)*
0.2408 (0.0728, 0.7968)
0.0583 (0.0252, 0.1350)*
0.3445 (0.0294, 2.3400)
GCDCA
3.3958 (1.7277, 6.6742)
2.6308 (0.7395, 9.3586)
3.4186 (1.4648, 7.9788)
1.7610 (0.5870, 5.2829)
3.0607 (1.4158, 6.6167)
0.5460 (0.1130, 4.3400)
TCDCA
1.1414 (0.5019, 2.5960)
0.2730 (0.0583, 1.2776)
1.6008 (0.5711, 4.4867)
0.3453 (0.0908, 1.3133)
1.3209 (0.5173, 3.3731)
0.1095 (0.0177, 1.1900)
DCA
0.1264 (0.0552, 0.2892)
0.0840 (0.0177, 0.3980)
0.0284 (0.0100, 0.0801)*
0.2234 (0.0581, 0.8586)
0.0428 (0.0167, 0.1102)
0.2665 (0.0000, 0.7360)
GDCA
0.2337 (0.0891, 0.6126)
0.1327 (0.0217, 0.8109)
0.2669 (0.0797, 0.8940)
0.3061 (0.0639, 1.4669)
0.1427 (0.0475, 0.4284)
0.1570 (0.0000, 1.8200)
TDCA
0.0984 (0.0466, 0.2076)
0.0244 (0.0060, 0.0992)
0.1251 (0.0490, 0.3192)
0.0758 (0.0225, 0.2552)
0.0791 (0.0337, 0.1854)
0.0219 (0.0000, 0.3980)
LCA
0.0238 (0.0158, 0.0357)
0.0151 (0.0070, 0.0323)
0.0175 (0.0105, 0.0291)
0.0328 (0.0169, 0.0635)
0.0095 (0.0060, 0.0151)**
0.0103 (0.0000, 0.0291)
GLCA
0.0234 (0.0160, 0.0342)
0.0114 (0.0056, 0.0233)
0.0098 (0.0061, 0.0158)**
0.0266 (0.0143, 0.0493)
0.0179 (0.0116, 0.0276)
0.0071 (0.0000, 0.0338)
TLCA
0.0183 (0.0107, 0.0314)
0.0034 (0.0012, 0.0094)**
0.0178 (0.0091, 0.0348)
0.0138 (0.0058, 0.0330)
0.0145 (0.0079, 0.0267)
0.0057 (0.0000, 0.0231)
UDCA
0.0505 (0.0233, 0.1097)
0.3348 (0.0781, 1.4358)*
0.0178 (0.0067, 0.0470)
0.0800 (0.0227, 0.2822)
0.0308 (0.0127, 0.0747)
0.1975 (0.0000, 0.6030)
GUDCA
0.2576 (0.1052, 0.6310)
0.8175 (0.1520, 4.3961)
0.1544 (0.0502, 0.4750)
0.1648 (0.0384, 0.7069)
0.2442 (0.0879, 0.6787)
0.2110 (0.0145, 1.4200)
TUDCA
0.0383 (0.0157, 0.0936)
0.0251 (0.0047, 0.1341)
0.0217 (0.0051, 0.0926)
0.0217 (0.0051, 0.0926)
0.0463 (0.0167, 0.1281)
0.0085 (0.0000, 0.1510)
12-KLCA
0.0397 (0.0289, 0.0546)
0.0608 (0.0335, 0.1103)
0.0253 (0.0170, 0.0376)
0.0398 (0.0237, 0.0667)
0.0249 (0.0173, 0.0358)
0.0101 (0.0000, 0.0943)
The values in patients with liver disease are the least square geometric mean concentrations with 95% CI. The values in healthy controls are the median with 2.5% point and 97.5% point. < 0.01 and < 0.05 versus viral hepatitis in patients with liver disease.