Research Article

Analysis of the Serum Bile Acid Composition for Differential Diagnosis in Patients with Liver Disease

Table 4

(a) The results of a comparison of the serum bile acids among different etiologies of liver diseases in patients with UDCA treatment. (b) The results of a comparison of the serum bile acids among different etiologies of liver diseases in patients without UDCA treatment.
(a)

(μM)Viral hepatitis
(HBV + HCV)
ALDBiliary tract diseaseNAFLDOther liver diseasesHealthy controls

409531146

CA0.0788 (0.0440, 0.1413)0.1851 (0.0462, 0.7409)0.1414 (0.0276, 0.7236)1.2708 (0.1102, 14.649)*0.2271 (0.0745, 0.6921)0.0638 (0.0129, 0.9090)
GCA0.5557 (0.3718, 0.8306)2.5674 (0.9881, 6.6709)**3.4416 (1.1186, 10.589)**3.8566 (0.7168, 20.750)*1.0244 (0.4757, 2.2061)0.1235 (0.0206, 2.7400)
TCA0.1479 (0.0873, 0.2503)0.7570 (0.2167, 2.6445) 1.0705 (0.2456, 4.6665)*0.7062 (0.0779, 6.4018)0.2248 (0.0823, 0.6141)0.0157 (0.0016, 0.9240)
CDCA0.3485 (0.1975, 0.6151)0.5274 (0.1368, 2.0341)0.3220 (0.0658, 1.5771)3.7919 (0.3514, 40.922)0.7003 (0.2368, 2.0715)0.3445 (0.0294, 2.3400)
GCDCA2.4618 (1.7090, 3.5462)8.1448 (3.4220, 19.386)*10.005 (3.6055, 27.763)*13.048 (2.8304, 60.149)*3.6051 (1.7962, 7.2358)0.5460 (0.1130, 4.3400)
TCDCA0.6805 (0.4143, 1.1177)2.4085 (0.7408, 7.8300)4.1830 (1.0444, 16.754)*2.0567 (0.2575, 16.426)0.7495 (0.2907, 1.9326)0.1095 (0.0177, 1.1900)
DCA0.1406 (0.0736, 0.2686)0.0804 (0.0173, 0.3742)0.0356 (0.0058, 0.2174)0.0830 (0.0055, 1.2468)0.1628 (0.0473, 0.5600)0.2665 (0.0000, 0.7360)
GDCA0.2278 (0.1124, 0.4618)0.1826 (0.0341, 0.9781)0.0482 (0.0067, 0.3474)0.1359 (0.0071, 2.6181)0.2567 (0.0666, 0.9888)0.1570 (0.0000, 1.8200)
TDCA0.0624 (0.0355, 0.1099)0.0620 (0.0162, 0.2376)0.0509 (0.0105, 0.2472)0.0599 (0.0056, 0.6386)0.0411 (0.0140, 0.1209)0.0219 (0.0000, 0.3980)
LCA0.0275 (0.0186, 0.0408)0.0283 (0.0111, 0.0719)0.0165 (0.0055, 0.0494)0.0520 (0.0101, 0.2688)0.0392 (0.0185, 0.0829)0.0103 (0.0000, 0.0291)
GLCA0.0252 (0.0159, 0.0401)0.0219 (0.0073, 0.0657)0.0293 (0.0080, 0.1069)0.0305 (0.0044, 0.2114)0.0299 (0.0124, 0.0723)0.0071 (0.0000, 0.0338)
TLCA0.0149 (0.0098, 0.0228)0.0198 (0.0073, 0.0541)0.0213 (0.0065, 0.0694)0.0078 (0.0013, 0.0455)0.0099 (0.0044, 0.0221)0.0057 (0.0000, 0.0231)
UDCA1.5203 (0.8882, 2.6022)5.1120 (1.4256, 18.330)0.8803 (0.1958, 3.9572)1.2878 (0.1357, 12.224)2.6510 (0.9503, 7.3956)0.1975 (0.0000, 0.6030)
GUDCA4.2367 (2.6009, 6.9014)21.824 (6.8462, 69.568)*9.8971 (2.5289, 38.734)5.9534 (0.7717, 45.926)6.1963 (2.4413, 15.727)0.2110 (0.0145, 1.4200)
TUDCA0.4544 (0.2526, 0.8173)2.4936 (0.6179, 10.063)*1.4632 (0.2833, 7.5587)0.2802 (0.0240, 3.2756)0.4095 (0.1335, 1.2561)0.0085 (0.0000, 0.1510)
12-KLCA0.0707 (0.0469, 0.1067)0.0319 (0.0120, 0.0846)0.0796 (0.0252, 0.2511)0.1449 (0.0259, 0.8101)0.0469 (0.0214, 0.1029)0.0101 (0.0000, 0.0943)

The values in patients with liver disease are the least square geometric mean concentrations with 95% CI.
The values in healthy controls are the median with 2.5% point and 97.5% point.
< 0.01 and < 0.05 versus viral hepatitis in patients with liver disease.
(b)

(μM)Viral hepatitis
(HBV + HCV)
ALDBiliary tract diseaseNAFLDOther liver diseasesHealthy controls

271215101846

CA0.1038 (0.0536, 0.2008)0.1134 (0.0328, 0.3918)0.0461 (0.0201, 0.1055)0.1123 (0.0384, 0.3284)0.0398 (0.0187, 0.0844)0.0638 (0.0129, 0.9090)
GCA1.2768 (0.5390, 3.0246)0.4700 (0.0930, 2.3740)1.6582 (0.5622, 4.8914)0.5272 (0.1297, 2.1427)1.6791 (0.6277, 4.4916)0.1235 (0.0206, 2.7400)
TCA0.4047 (0.1493, 1.0971)0.0527 (0.0081, 0.3428)0.6966 (0.1994, 2.4335)0.1199 (0.0237, 0.6067)0.6846 (0.2194, 2.1360)0.0157 (0.0016, 0.9240)
CDCA0.1874 (0.0898, 0.3912)0.8048 (0.2020, 3.2062)0.0532 (0.0211, 0.1339)*0.2408 (0.0728, 0.7968)0.0583 (0.0252, 0.1350)*0.3445 (0.0294, 2.3400)
GCDCA3.3958 (1.7277, 6.6742)2.6308 (0.7395, 9.3586)3.4186 (1.4648, 7.9788)1.7610 (0.5870, 5.2829)3.0607 (1.4158, 6.6167)0.5460 (0.1130, 4.3400)
TCDCA1.1414 (0.5019, 2.5960)0.2730 (0.0583, 1.2776)1.6008 (0.5711, 4.4867)0.3453 (0.0908, 1.3133)1.3209 (0.5173, 3.3731)0.1095 (0.0177, 1.1900)
DCA0.1264 (0.0552, 0.2892)0.0840 (0.0177, 0.3980)0.0284 (0.0100, 0.0801)*0.2234 (0.0581, 0.8586)0.0428 (0.0167, 0.1102)0.2665 (0.0000, 0.7360)
GDCA0.2337 (0.0891, 0.6126)0.1327 (0.0217, 0.8109)0.2669 (0.0797, 0.8940)0.3061 (0.0639, 1.4669)0.1427 (0.0475, 0.4284)0.1570 (0.0000, 1.8200)
TDCA0.0984 (0.0466, 0.2076)0.0244 (0.0060, 0.0992)0.1251 (0.0490, 0.3192)0.0758 (0.0225, 0.2552)0.0791 (0.0337, 0.1854)0.0219 (0.0000, 0.3980)
LCA0.0238 (0.0158, 0.0357)0.0151 (0.0070, 0.0323)0.0175 (0.0105, 0.0291)0.0328 (0.0169, 0.0635)0.0095 (0.0060, 0.0151)**0.0103 (0.0000, 0.0291)
GLCA0.0234 (0.0160, 0.0342)0.0114 (0.0056, 0.0233)0.0098 (0.0061, 0.0158)**0.0266 (0.0143, 0.0493)0.0179 (0.0116, 0.0276)0.0071 (0.0000, 0.0338)
TLCA0.0183 (0.0107, 0.0314)0.0034 (0.0012, 0.0094)**0.0178 (0.0091, 0.0348)0.0138 (0.0058, 0.0330)0.0145 (0.0079, 0.0267)0.0057 (0.0000, 0.0231)
UDCA0.0505 (0.0233, 0.1097)0.3348 (0.0781, 1.4358)*0.0178 (0.0067, 0.0470)0.0800 (0.0227, 0.2822)0.0308 (0.0127, 0.0747)0.1975 (0.0000, 0.6030)
GUDCA0.2576 (0.1052, 0.6310)0.8175 (0.1520, 4.3961)0.1544 (0.0502, 0.4750)0.1648 (0.0384, 0.7069)0.2442 (0.0879, 0.6787)0.2110 (0.0145, 1.4200)
TUDCA0.0383 (0.0157, 0.0936)0.0251 (0.0047, 0.1341)0.0217 (0.0051, 0.0926)0.0217 (0.0051, 0.0926)0.0463 (0.0167, 0.1281)0.0085 (0.0000, 0.1510)
12-KLCA0.0397 (0.0289, 0.0546)0.0608 (0.0335, 0.1103)0.0253 (0.0170, 0.0376)0.0398 (0.0237, 0.0667)0.0249 (0.0173, 0.0358)0.0101 (0.0000, 0.0943)

The values in patients with liver disease are the least square geometric mean concentrations with 95% CI.
The values in healthy controls are the median with 2.5% point and 97.5% point.
< 0.01 and < 0.05 versus viral hepatitis in patients with liver disease.