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Gastroenterology Research and Practice
Volume 2015, Article ID 723954, 13 pages
http://dx.doi.org/10.1155/2015/723954
Review Article

Assessing of Celiac Disease and Nonceliac Gluten Sensitivity

1Unidad Académica de Ciencias de la Nutrición, Universidad Autónoma de Sinaloa, Avenida Cedros y Calle Sauces, S/N, Fracc. Los Fresnos, 80019 Culiacán, SIN, Mexico
2Programa Regional de Doctorado en Biotecnología, FCQB, Universidad Autónoma de Sinaloa, Ciudad Universitaria, 80040 Culiacán, SIN, Mexico
3Immunology Division, Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC 3052, Australia

Received 19 November 2014; Accepted 15 April 2015

Academic Editor: Leticia Moreira

Copyright © 2015 N. Ontiveros et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. J. R. Biesiekierski, S. L. Peters, E. D. Newnham, O. Rosella, J. G. Muir, and P. R. Gibson, “No effects of gluten in patients with self-reported non-celiac gluten sensitivity after dietary reduction of fermentable, poorly absorbed, short-chain carbohydrates,” Gastroenterology, vol. 145, no. 2, pp. 320–328, 2013. View at Publisher · View at Google Scholar · View at Scopus
  2. S. L. Peters, J. R. Biesiekierski, G. W. Yelland, J. G. Muir, and P. R. Gibson, “Randomised clinical trial: gluten may cause depression in subjects with non-coeliac gluten sensitivity—an exploratory clinical study,” Alimentary Pharmacology and Therapeutics, vol. 39, no. 10, pp. 1104–1112, 2014. View at Publisher · View at Google Scholar · View at Scopus
  3. Y. Junker, S. Zeissig, S.-J. Kim et al., “Wheat amylase trypsin inhibitors drive intestinal inflammation via activation of toll-like receptor 4,” Journal of Experimental Medicine, vol. 209, no. 13, pp. 2395–2408, 2012. View at Publisher · View at Google Scholar · View at Scopus
  4. S. J. Genuis and R. A. Lobo, “Gluten sensitivity presenting as a neuropsychiatric disorder,” Gastroenterology Research and Practice, vol. 2014, Article ID 293206, 6 pages, 2014. View at Publisher · View at Google Scholar
  5. U. Volta, F. Tovoli, R. Cicola et al., “Serological tests in gluten sensitivity (nonceliac gluten intolerance),” Journal of Clinical Gastroenterology, vol. 46, no. 8, pp. 680–685, 2012. View at Publisher · View at Google Scholar · View at Scopus
  6. U. Volta and R. de Giorgio, “New understanding of gluten sensitivity,” Nature Reviews Gastroenterology and Hepatology, vol. 9, no. 5, pp. 295–299, 2012. View at Publisher · View at Google Scholar · View at Scopus
  7. K. Kaukinen, K. Lindfors, P. Collin, O. Koskinen, and M. Mäki, “Coeliac disease—a diagnostic and therapeutic challenge,” Clinical Chemistry and Laboratory Medicine, vol. 48, no. 9, pp. 1205–1216, 2010. View at Publisher · View at Google Scholar · View at Scopus
  8. A. V. Stazi, A. Trecca, and B. Trinti, “Osteoporosis in celiac disease and in endocrine and reproductive disorders,” World Journal of Gastroenterology, vol. 14, no. 4, pp. 498–505, 2008. View at Publisher · View at Google Scholar · View at Scopus
  9. M. H. Emami, S. Karimi, and S. Kouhestani, “Is routine duodenal biopsy necessary for the detection of celiac disease in patients presenting with iron deficiency anemia?” International Journal of Preventive Medicine, vol. 3, no. 4, pp. 273–277, 2012. View at Google Scholar
  10. D. Bansal, A. Trehan, M. K. Gupta, N. Varma, and R. K. Marwaha, “Serodiagnosis of celiac disease in children referred for evaluation of anemia: a pediatric hematology unit's experience,” Indian Journal of Pathology and Microbiology, vol. 54, no. 4, pp. 756–760, 2011. View at Publisher · View at Google Scholar · View at Scopus
  11. C. Catassi and A. Fasano, “Celiac disease as a cause or growth retardation in childhood,” Current Opinion in Pediatrics, vol. 16, no. 4, pp. 445–449, 2004. View at Publisher · View at Google Scholar · View at Scopus
  12. M. Pietzak, “Celiac disease, wheat allergy, and gluten sensitivity: when gluten free is not a fad,” Journal of Parenteral and Enteral Nutrition, vol. 36, supplement 1, pp. 68S–75S, 2012. View at Publisher · View at Google Scholar · View at Scopus
  13. A. Sapone, J. C. Bai, C. Ciacci et al., “Spectrum of gluten-related disorders: consensus on new nomenclature and classification,” BMC Medicine, vol. 10, article 13, 2012. View at Publisher · View at Google Scholar · View at Scopus
  14. T. A. Kabbani, R. R. Vanga, D. A. Leffler et al., “Celiac disease or non-celiac gluten sensitivity? An approach to clinical differential diagnosis,” American Journal of Gastroenterology, vol. 109, no. 5, pp. 741–746, 2014. View at Publisher · View at Google Scholar · View at Scopus
  15. M. H. Emami, S. Kouhestani, S. Karimi et al., “Frequency of celiac disease in adult patients with typical or atypical malabsorption symptoms in Isfahan, Iran,” Gastroenterology Research and Practice, vol. 2012, Article ID 106965, 6 pages, 2012. View at Publisher · View at Google Scholar · View at Scopus
  16. R. Kochhar, K. Jain, B. R. Thapa et al., “Clinical presentation of celiac disease among pediatric compared to adolescent and adult patients,” Indian Journal of Gastroenterology, vol. 31, no. 3, pp. 116–120, 2012. View at Publisher · View at Google Scholar · View at Scopus
  17. E. Roma, J. Panayiotou, H. Karantana et al., “Changing pattern in the clinical presentation of pediatric celiac disease: a 30-year study,” Digestion, vol. 80, no. 3, pp. 185–191, 2009. View at Publisher · View at Google Scholar · View at Scopus
  18. N. Balamtekin, N. Uslu, G. Baysoy et al., “The presentation of celiac disease in 220 Turkish children,” Turkish Journal of Pediatrics, vol. 52, no. 3, pp. 239–244, 2010. View at Google Scholar · View at Scopus
  19. B. Admou, L. Essaadouni, K. Krati et al., “Atypical celiac disease: from recognizing to managing,” Gastroenterology Research and Practice, vol. 2012, Article ID 637187, 9 pages, 2012. View at Publisher · View at Google Scholar · View at Scopus
  20. A. Ganji, A. Esmaielzadeh, M. A. Aghayee, L. Goshayeshi, and K. Ghaffarzadegan, “The clinical presentation of celiac disease: experiences from Northeastern Iran,” Middle East Journal of Digestive Diseases, vol. 6, no. 2, pp. 93–97, 2014. View at Google Scholar
  21. S. Husby, S. Koletzko, I. R. Korponay-Szabó et al., “European society for pediatric gastroenterology, hepatology, and nutrition guidelines for the diagnosis of coeliac disease,” Journal of Pediatric Gastroenterology and Nutrition, vol. 54, no. 1, pp. 136–160, 2012. View at Publisher · View at Google Scholar · View at Scopus
  22. J. F. Ludvigsson, D. A. Leffler, J. C. Bai et al., “The Oslo definitions for coeliac disease and related terms,” Gut, vol. 62, no. 1, pp. 43–52, 2013. View at Publisher · View at Google Scholar · View at Scopus
  23. M. N. Marsh, I. Bjarnason, J. Shaw, A. Ellis, R. Baker, and T. J. Peters, “Studies of intestinal lymphoid tissue. XIV-HLA status, mucosal morphology, permeability and epithelial lymphocyte populations in first degree relatives of patients with coeliac disease,” Gut, vol. 31, no. 1, pp. 32–36, 1990. View at Publisher · View at Google Scholar · View at Scopus
  24. M. N. Marsh, “Gluten, major histocompatibility complex, and the small intestine: a molecular and immunobiologic approach to the spectrum of gluten sensitivity (‘celiac sprue’),” Gastroenterology, vol. 102, no. 1, pp. 330–354, 1992. View at Google Scholar · View at Scopus
  25. G. Oberhuber, G. Granditsch, and H. Vogelsang, “The histopathology of coeliac disease: Time for a standardized report scheme for pathologists,” European Journal of Gastroenterology and Hepatology, vol. 11, no. 10, pp. 1185–1194, 1999. View at Google Scholar · View at Scopus
  26. G. R. Corazza and V. Villanacci, “Coeliac disease,” Journal of Clinical Pathology, vol. 58, no. 6, pp. 573–574, 2005. View at Publisher · View at Google Scholar · View at Scopus
  27. G. R. Corazza, V. Villanacci, C. Zambelli et al., “Comparison of the interobserver reproducibility with different histologic criteria used in celiac disease,” Clinical Gastroenterology and Hepatology, vol. 5, no. 7, pp. 838–843, 2007. View at Publisher · View at Google Scholar · View at Scopus
  28. K. Karell, A. S. Louka, S. J. Moodie et al., “HLA types in celiac disease patients not carrying the DQA105-DQB102 (DQ2) heterodimer: results from the European Genetics Cluster on Celiac Disease,” Human Immunology, vol. 64, no. 4, pp. 469–477, 2003. View at Publisher · View at Google Scholar · View at Scopus
  29. K. Alarida, J. Harown, M. R. Di Pierro, S. Drago, and C. Catassi, “HLA-DQ2 and -DQ8 genotypes in celiac and healthy Libyan children,” Digestive and Liver Disease, vol. 42, no. 6, pp. 425–427, 2010. View at Publisher · View at Google Scholar · View at Scopus
  30. F. Megiorni, B. Mora, M. Bonamico et al., “HLA-DQ and risk gradient for celiac disease,” Human Immunology, vol. 70, no. 1, pp. 55–59, 2009. View at Publisher · View at Google Scholar · View at Scopus
  31. S. Tollefsen, K. Hotta, X. Chen et al., “Structural and functional studies of trans-encoded HLA-DQ2.3 (DQA103:01/DQB102:01) protein molecule,” The Journal of Biological Chemistry, vol. 287, no. 17, pp. 13611–13619, 2012. View at Publisher · View at Google Scholar · View at Scopus
  32. Y. Kooy-Winkelaar, M. Van Lummel, A. K. Moustakas et al., “Gluten-specific T cells cross-react between HLA-DQ8 and the HLA-DQ2α/DQ8β transdimer,” Journal of Immunology, vol. 187, no. 10, pp. 5123–5129, 2011. View at Publisher · View at Google Scholar · View at Scopus
  33. M. Bodd, S. Tollefsen, E. Bergseng, K. E. A. Lundin, and L. M. Sollid, “Evidence that HLA-DQ9 confers risk to celiac disease by presence of DQ9-restricted gluten-specific T cells,” Human Immunology, vol. 73, no. 4, pp. 376–381, 2012. View at Publisher · View at Google Scholar · View at Scopus
  34. P. Margaritte-Jeannin, M. C. Babron, M. Bourgey et al., “HLA-DQ relative risks for coeliac disease in European populations: a study of the European Genetics Cluster on Coeliac Disease,” Tissue Antigens, vol. 63, no. 6, pp. 562–567, 2004. View at Publisher · View at Google Scholar · View at Scopus
  35. M. Bodd, C. Kim, K. E. A. Lundin, and L. M. Sollid, “T-cell response to gluten in patients with HLA-DQ2.2 reveals requirement of peptide-MHC stability in celiac disease,” Gastroenterology, vol. 142, no. 3, pp. 552–561, 2012. View at Publisher · View at Google Scholar · View at Scopus
  36. L.-E. Fallang, E. Bergseng, K. Hotta, A. Berg-Larsen, C.-Y. Kim, and L. M. Sollid, “Differences in the risk of celiac disease associated with HLA-DQ2.5 or HLA-DQ2.2 are related to sustained gluten antigen presentation,” Nature Immunology, vol. 10, no. 10, pp. 1096–1101, 2009. View at Publisher · View at Google Scholar · View at Scopus
  37. R. Ploski, J. Ek, E. Thorsby, and L. M. Sollid, “On the HLA-DQ(α1*0501, β1*0201)-associated susceptibility in celiac disease: a possible gene dosage effect of DQB1*0201,” Tissue Antigens, vol. 41, no. 4, pp. 173–177, 1993. View at Publisher · View at Google Scholar · View at Scopus
  38. S.-W. Qiao, R. Iversen, M. Ráki, and L. M. Sollid, “The adaptive immune response in celiac disease,” Seminars in Immunopathology, vol. 34, no. 4, pp. 523–540, 2012. View at Publisher · View at Google Scholar · View at Scopus
  39. A. Ferguson, E. Arranz, and S. O'Mahony, “Clinical and pathological spectrum of coeliac disease—active, silent, latent, potential,” Gut, vol. 34, no. 2, pp. 150–151, 1993. View at Publisher · View at Google Scholar · View at Scopus
  40. R. Troncone and B. Jabri, “Coeliac disease and gluten sensitivity,” Journal of Internal Medicine, vol. 269, no. 6, pp. 582–590, 2011. View at Publisher · View at Google Scholar · View at Scopus
  41. A. Sapone, K. M. Lammers, V. Casolaro et al., “Divergence of gut permeability and mucosal immune gene expression in two gluten-associated conditions: celiac disease and gluten sensitivity,” BMC Medicine, vol. 9, article 23, 2011. View at Publisher · View at Google Scholar · View at Scopus
  42. M. J. Mäkelä, C. Eriksson, A. Kotaniemi-Syrjänen et al., “Wheat allergy in children—new tools for diagnostics,” Clinical & Experimental Allergy, vol. 44, no. 11, pp. 1420–1430, 2014. View at Publisher · View at Google Scholar
  43. J. R. Biesiekierski, J. G. Muir, and P. R. Gibson, “Is gluten a cause of gastrointestinal symptoms in people without celiac disease?” Current Allergy and Asthma Reports, vol. 13, no. 6, pp. 631–638, 2013. View at Publisher · View at Google Scholar · View at Scopus
  44. N. Ontiveros, L. K. Flores-Mendoza, V. A. Canizalez-Román, and F. Cabrera-Chávez, “Food allergy: prevalence and food technology approaches for the control of IgE-mediated food allergy,” Austin Journal of Nutrition and Food Sciences, vol. 2, no. 5, article 1029, 2014. View at Google Scholar
  45. N. Bizzaro, R. Tozzoli, D. Villalta, M. Fabris, and E. Tonutti, “Cutting-Edge issues in celiac disease and in gluten intolerance,” Clinical Reviews in Allergy and Immunology, vol. 42, no. 3, pp. 279–287, 2012. View at Publisher · View at Google Scholar · View at Scopus
  46. A. Kotaniemi-Syrjänen, K. Palosuo, T. Jartti, M. Kuitunen, A. S. Pelkonen, and M. J. Mäkelä, “The prognosis of wheat hypersensitivity in children,” Pediatric Allergy and Immunology, vol. 21, no. 2, pp. e421–e428, 2010. View at Publisher · View at Google Scholar · View at Scopus
  47. A. Vojdani and D. Perlmutter, “Differentiation between celiac disease, nonceliac gluten sensitivity, and their overlapping with Crohn's disease: a case series,” Case Reports in Immunology, vol. 2013, Article ID 248482, 9 pages, 2013. View at Publisher · View at Google Scholar
  48. G. J. Mantzaris, A. Roussos, S. Koilakou et al., “Prevalence of celiac disease in patients with Crohn's disease,” Inflammatory Bowel Diseases, vol. 11, no. 11, p. 1029, 2005. View at Publisher · View at Google Scholar · View at Scopus
  49. J. S. Leeds, B. S. Höroldt, R. Sidhu et al., “Is there an association between coeliac disease and inflammatory bowel diseases? A study of relative prevalence in comparison with population controls,” Scandinavian Journal of Gastroenterology, vol. 42, no. 10, pp. 1214–1220, 2007. View at Publisher · View at Google Scholar · View at Scopus
  50. A. Tursi, G. M. Giorgetti, G. Brandimarte, and W. Elisei, “High prevalence of celiac disease among patients affected by Crohn's disease,” Inflammatory Bowel Diseases, vol. 11, no. 7, pp. 662–666, 2005. View at Publisher · View at Google Scholar · View at Scopus
  51. A. Yang, Y. Chen, E. Scherl, A. I. Neugut, G. Bhagat, and P. H. R. Green, “Inflammatory bowel disease in patients with celiac disease,” Inflammatory Bowel Diseases, vol. 11, no. 6, pp. 528–532, 2005. View at Publisher · View at Google Scholar · View at Scopus
  52. J. Patel, A. Agasti, S. Rao, M. G. Srinivas, M. Patel, and P. Sawant, “Celiac disease preceding Crohn's disease?” Tropical Gastroenterology, vol. 32, no. 3, pp. 236–238, 2011. View at Google Scholar · View at Scopus
  53. E. C. Oxford, D. D. Nguyen, J. Sauk et al., “Impact of coexistent celiac disease on phenotype and natural history of inflammatory bowel diseases,” American Journal of Gastroenterology, vol. 108, no. 7, pp. 1123–1129, 2013. View at Publisher · View at Google Scholar · View at Scopus
  54. E. A. M. Festen, A. M. Szperl, R. K. Weersma, C. Wijmenga, and M. C. Wapenaar, “Inflammatory bowel disease and celiac disease: overlaps in the pathology and genetics, and their potential drug targets,” Endocrine, Metabolic and Immune Disorders—Drug Targets, vol. 9, no. 2, pp. 199–218, 2009. View at Publisher · View at Google Scholar · View at Scopus
  55. V. Pascual, R. Dieli-Crimi, N. López-Palacios, A. Bodas, L. M. Medrano, and C. Núñez, “Inflammatory bowel disease and celiac disease: overlaps and differences,” World Journal of Gastroenterology, vol. 20, no. 17, pp. 4846–4856, 2014. View at Publisher · View at Google Scholar · View at Scopus
  56. W. Häuser, K.-H. Janke, B. Klump, M. Gregor, and A. Hinz, “Anxiety and depression in adult patients with celiac disease on a gluten-free diet,” World Journal of Gastroenterology, vol. 16, no. 22, pp. 2780–2787, 2010. View at Publisher · View at Google Scholar · View at Scopus
  57. A. Tursi, G. M. Giorgetti, G. Brandimarte, and W. Elisei, “Crohn's disease and celiac disease: association or epiphenomenon?” European Review for Medical and Pharmacological Sciences, vol. 10, no. 3, pp. 127–130, 2006. View at Google Scholar · View at Scopus
  58. U. Wahnschaffe, J.-D. Schulzke, M. Zeitz, and R. Ullrich, “Predictors of clinical response to gluten-free diet in patients diagnosed with diarrhea-predominant irritable bowel syndrome,” Clinical Gastroenterology and Hepatology, vol. 5, no. 7, pp. 844–850, 2007. View at Publisher · View at Google Scholar · View at Scopus
  59. E. P. Halmos, V. A. Power, S. J. Shepherd, P. R. Gibson, and J. G. Muir, “A diet low in FODMAPs reduces symptoms of irritable bowel syndrome,” Gastroenterology, vol. 146, no. 1, pp. 67–75, 2014. View at Publisher · View at Google Scholar · View at Scopus
  60. E. F. Verdu, D. Armstrong, and J. A. Murray, “Between celiac disease and irritable bowel syndrome: the ‘ no man's land’ of gluten sensitivity,” American Journal of Gastroenterology, vol. 104, no. 6, pp. 1587–1594, 2009. View at Publisher · View at Google Scholar · View at Scopus
  61. C. O'Leary, P. Wieneke, S. Buckley et al., “Celiac disease and irritable bowel-type symptoms,” American Journal of Gastroenterology, vol. 97, no. 6, pp. 1463–1467, 2002. View at Publisher · View at Google Scholar · View at Scopus
  62. F. Cristofori, C. Fontana, A. Magistà et al., “Increased prevalence of celiac disease among pediatric patients with irritable bowel syndrome: a 6-year prospective cohort study,” JAMA Pediatrics, vol. 168, no. 6, pp. 555–560, 2014. View at Publisher · View at Google Scholar
  63. J. R. Biesiekierski, E. D. Newnham, P. M. Irving et al., “Gluten Causes gastrointestinal symptoms in subjects without celiac disease: a double-blind randomized placebo-controlled trial,” American Journal of Gastroenterology, vol. 106, no. 3, pp. 508–514, 2011. View at Publisher · View at Google Scholar · View at Scopus
  64. M. Hadjivassiliou, R. H. Kandler, A. K. Chattopadhyay et al., “Dietary treatment of gluten neuropathy,” Muscle and Nerve, vol. 34, no. 6, pp. 762–766, 2006. View at Publisher · View at Google Scholar · View at Scopus
  65. R. Troncone and A. Ferguson, “Anti-gliadin antibodies,” Journal of Pediatric Gastroenterology and Nutrition, vol. 12, no. 2, pp. 150–158, 1991. View at Publisher · View at Google Scholar · View at Scopus
  66. M. ten Dam, Y. van de Wal, M. L. Mearin et al., “Anti-alpha-gliadin antibodies (AGA) in the serum of coeliac children and controls recognize an identical collection of linear epitopes of alpha-gliadin,” Clinical & Experimental Immunology, vol. 114, no. 2, pp. 189–195, 1998. View at Google Scholar
  67. C. Ribes Coninckx, J. P. Giliams, I. Polanco, and A. S. Pena, “IgA antigliadin antibodies in celiac and inflammatory bowel disease,” Journal of Pediatric Gastroenterology and Nutrition, vol. 3, no. 5, pp. 676–682, 1984. View at Publisher · View at Google Scholar · View at Scopus
  68. E. K. George, M. L. Mearin, J. Bouquet et al., “Screening for coeliac disease in Dutch children with associated diseases,” Acta Paediatrica, vol. 85, no. 412, pp. 52–53, 1996. View at Google Scholar · View at Scopus
  69. J. Jackson, W. Eathon, N. Cascella et al., “Gluten sensitivity and relationship to psychiatric symptoms in people with schizophrenia,” Schizophrenia Research, vol. 159, no. 2-3, pp. 539–542, 2014. View at Publisher · View at Google Scholar
  70. C. Lagerqvist, I. Dahlbom, T. Hansson et al., “Antigliadin immunoglobulin a best in finding celiac disease in children younger than 18 months of age,” Journal of Pediatric Gastroenterology and Nutrition, vol. 47, no. 4, pp. 428–435, 2008. View at Publisher · View at Google Scholar · View at Scopus
  71. B. Foucher, C. Johanet, S. Jégo-Desplat et al., “Are immunoglobulin a anti-gliadin antibodies helpful in diagnosing coeliac disease in children younger than 2 years?” Journal of Pediatric Gastroenterology and Nutrition, vol. 54, no. 1, pp. 110–112, 2012. View at Publisher · View at Google Scholar · View at Scopus
  72. V. Villanacci, P. Ceppa, E. Tavani, C. Vindigni, and U. Volta, “Coeliac disease: the histology report,” Digestive and Liver Disease, vol. 43, supplement 4, pp. S385–S395, 2011. View at Publisher · View at Google Scholar · View at Scopus
  73. T. P. Chorzelski, E. H. Beutner, J. Sulej et al., “IgA anti-endomysium antibody. A new immunological marker of dermatitis herpetiformis and coeliac disease,” British Journal of Dermatology, vol. 111, no. 4, pp. 395–402, 1984. View at Publisher · View at Google Scholar · View at Scopus
  74. T. P. Chorzelski, J. Sulej, H. Tchorzewska, S. Jablonska, E. H. Beutner, and V. Kumar, “IgA class endomysium antibodies in dermatitis herpetiformis and coeliac disease,” Annals of the New York Academy of Sciences, vol. 420, pp. 325–334, 1983. View at Publisher · View at Google Scholar · View at Scopus
  75. S. Sulkanen, T. Halttunen, K. Laurila et al., “Tissue transglutaminase autoantibody enzyme-linked immunosorbent assay in detecting celiac disease,” Gastroenterology, vol. 115, no. 6, pp. 1322–1328, 1998. View at Publisher · View at Google Scholar · View at Scopus
  76. M.-L. Lähdeaho, M. Mäki, K. Laurila, H. Huhtala, and K. Kaukinen, “Small-bowel mucosal changes and antibody responses after low- and moderate-dose gluten challenge in celiac disease,” BMC Gastroenterology, vol. 11, article 129, 2011. View at Publisher · View at Google Scholar · View at Scopus
  77. M. Parizade, Y. Bujanover, B. Weiss, V. Nachmias, and B. Shainberg, “Performance of serology assays for diagnosing celiac disease in a clinical setting,” Clinical and Vaccine Immunology, vol. 16, no. 11, pp. 1576–1582, 2009. View at Publisher · View at Google Scholar · View at Scopus
  78. E. Lionetti, S. Castellaneta, A. Pulvirenti et al., “Prevalence and natural history of potential celiac disease in at-family-risk infants prospectively investigated from birth,” Journal of Pediatrics, vol. 161, no. 5, pp. 908–e2, 2012. View at Publisher · View at Google Scholar · View at Scopus
  79. A. Rostom, C. Dubé, A. Cranney et al., “The diagnostic accuracy of serologic tests for celiac disease: a systematic review,” Gastroenterology, vol. 128, no. 4, supplement 1, pp. S38–S46, 2005. View at Publisher · View at Google Scholar · View at Scopus
  80. N. R. Lewis and B. B. Scott, “Meta-analysis: deamidated gliadin peptide antibody and tissue transglutaminase antibody compared as screening tests for coeliac disease,” Alimentary Pharmacology & Therapeutics, vol. 31, no. 1, pp. 73–81, 2010. View at Publisher · View at Google Scholar · View at Scopus
  81. A. Mubarak, F. Gmelig-Meyling, V. Wolters, F. Ten Kate, and R. Houwen, “Immunoglobulin G antibodies against deamidated-gliadin-peptides outperform anti-endomysium and tissue transglutaminase antibodies in children <2 years age,” APMIS, vol. 119, no. 12, pp. 894–900, 2011. View at Publisher · View at Google Scholar · View at Scopus
  82. W. Dieterich, T. Ehnis, M. Bauer et al., “Identification of tissue transglutaminase as the autoantigen of celiac disease,” Nature Medicine, vol. 3, no. 7, pp. 797–801, 1997. View at Publisher · View at Google Scholar · View at Scopus
  83. S. Rashtak, M. W. Ettore, H. A. Homburger, and J. A. Murray, “Comparative usefulness of deamidated gliadin antibodies in the diagnosis of celiac disease,” Clinical Gastroenterology and Hepatology, vol. 6, no. 4, pp. 426–432, 2008. View at Publisher · View at Google Scholar · View at Scopus
  84. E. V. Marietta, S. Rashtak, and J. A. Murray, “Correlation analysis of celiac sprue tissue transglutaminase and deamidated gliadin IgG/IgA,” World Journal of Gastroenterology, vol. 15, no. 7, pp. 845–848, 2009. View at Publisher · View at Google Scholar · View at Scopus
  85. L. M. Sollid, Ø. Molberg, S. Mcadam, and K. E. A. Lundin, “Autoantibodies in coeliac disease: tissue transglutaminase guilt by association?” Gut, vol. 41, no. 6, pp. 851–852, 1997. View at Publisher · View at Google Scholar · View at Scopus
  86. E. Zintzaras and A. E. Germenis, “Performance of antibodies against tissue transglutaminase for the diagnosis of celiac disease: meta-analysis,” Clinical and Vaccine Immunology, vol. 13, no. 2, pp. 187–192, 2006. View at Publisher · View at Google Scholar · View at Scopus
  87. A. Rostom, J. A. Murray, and M. F. Kagnoff, “American Gastroenterological Association (AGA) Institute technical review on the diagnosis and management of celiac disease,” Gastroenterology, vol. 131, no. 6, pp. 1981–2002, 2006. View at Publisher · View at Google Scholar · View at Scopus
  88. S. Simell, S. Hoppu, A. Hekkala et al., “Fate of five celiac disease-associated antibodies during normal diet in genetically at-risk children observed from birth in a natural history study,” The American Journal of Gastroenterology, vol. 102, no. 9, pp. 2026–2035, 2007. View at Publisher · View at Google Scholar · View at Scopus
  89. O. Waisbourd-Zinman, Y. Rosenbach, S. Shalitin et al., “Spontaneous normalization of anti-tissue transglutaminase antibody levels is common in children with type 1 diabetes mellitus,” Digestive Diseases and Sciences, vol. 57, no. 5, pp. 1314–1320, 2012. View at Publisher · View at Google Scholar · View at Scopus
  90. P. G. Hill and G. K. T. Holmes, “Coeliac disease: a biopsy is not always necessary for diagnosis,” Alimentary Pharmacology and Therapeutics, vol. 27, no. 7, pp. 572–577, 2008. View at Publisher · View at Google Scholar · View at Scopus
  91. I. Dahlbom, I. R. Korponay-Szabó, J. B. Kovács, Z. Szalai, M. Mäki, and T. Hansson, “Prediction of clinical and mucosal severity of coeliac disease and dermatitis herpetiformis by quantification of IgA/IgG serum antibodies to tissue transglutaminase,” Journal of Pediatric Gastroenterology and Nutrition, vol. 50, no. 2, pp. 140–146, 2010. View at Publisher · View at Google Scholar · View at Scopus
  92. F. Cataldo, V. Marino, A. Ventura, G. Bottaro, and G. R. Corazza, “Prevalence and clinical features of selective immunoglobulin A deficiency in coeliac disease: an Italian multicentre study. Italian Society of Paediatric Gastroenterology and Hepatology (SIGEP) and ‘Club del Tenue’ Working Groups on Coeliac Disease,” Gut, vol. 42, no. 3, pp. 362–365, 1998. View at Publisher · View at Google Scholar · View at Scopus
  93. E. Schirru, R.-D. Jores, and M. Congia, “Prudence is necessary in the application of the new ESPGHAN criteria for celiac disease omitting duodenal biopsy: a case report,” European Journal of Gastroenterology and Hepatology, vol. 26, no. 6, pp. 679–680, 2014. View at Publisher · View at Google Scholar · View at Scopus
  94. M. Aleanzi, A. M. Demonte, C. Esper, S. Garcilazo, and M. Waggener, “Antibody recognition against native and selectively deamidated gliadin peptides,” Clinical Chemistry, vol. 47, no. 11, pp. 2023–2028, 2001. View at Google Scholar
  95. E. Schwertz, F. Kahlenberg, U. Sack et al., “Serologic assay based on gliadin-related nonapeptides as a highly sensitive and specific diagnostic aid in celiac disease,” Clinical Chemistry, vol. 50, no. 12, pp. 2370–2375, 2004. View at Publisher · View at Google Scholar · View at Scopus
  96. E. Sugai, H. Vázquez, F. Nachman et al., “Accuracy of testing for antibodies to synthetic gliadin-related peptides in celiac disease,” Clinical Gastroenterology and Hepatology, vol. 4, no. 9, pp. 1112–1117, 2006. View at Publisher · View at Google Scholar · View at Scopus
  97. D. Agardh, “Antibodies against synthetic deamidated gliadin peptides and tissue transglutaminase for the identification of childhood celiac disease,” Clinical Gastroenterology and Hepatology, vol. 5, no. 11, pp. 1276–1281, 2007. View at Publisher · View at Google Scholar · View at Scopus
  98. K. Kaukinen, P. Collin, K. Laurila, T. Kaartinen, J. Partanen, and M. Mäki, “Resurrection of gliadin antibodies in coeliac disease. Deamidated gliadin peptide antibody test provides additional diagnostic benefit,” Scandinavian Journal of Gastroenterology, vol. 42, no. 12, pp. 1428–1433, 2007. View at Publisher · View at Google Scholar · View at Scopus
  99. U. Volta, A. Granito, E. Fiorini et al., “Usefulness of antibodies to deamidated gliadin peptides in celiac disease diagnosis and follow-up,” Digestive Diseases and Sciences, vol. 53, no. 6, pp. 1582–1588, 2008. View at Publisher · View at Google Scholar · View at Scopus
  100. D. Villalta, M. G. Alessio, M. Tampoia et al., “Testing for IgG class antibodies in celiac disease patients with selective IgA deficiency. A comparison of the diagnostic accuracy of 9 IgG anti-tissue transglutaminase, 1 IgG anti-gliadin and 1 IgG anti-deaminated gliadin peptide antibody assays,” Clinica Chimica Acta, vol. 382, no. 1-2, pp. 95–99, 2007. View at Publisher · View at Google Scholar · View at Scopus
  101. M. Parizade and B. Shainberg, “Positive deamidated gliadin peptide antibodies and negative tissue transglutaminase IgA antibodies in a pediatric population: to biopsy or not to biopsy,” Clinical and Vaccine Immunology, vol. 17, no. 5, pp. 884–886, 2010. View at Publisher · View at Google Scholar · View at Scopus
  102. M. M. Walker, J. A. Murray, J. Ronkainen et al., “Detection of celiac disease and lymphocytic enteropathy by parallel serology and histopathology in a population-based study,” Gastroenterology, vol. 139, no. 1, pp. 112–119, 2010. View at Publisher · View at Google Scholar · View at Scopus
  103. B. C. Dickson, C. J. Streutker, and R. Chetty, “Coeliac disease: an update for pathologists,” Journal of Clinical Pathology, vol. 59, no. 10, pp. 1008–1016, 2006. View at Publisher · View at Google Scholar · View at Scopus
  104. S. Kakar, D. S. Pardi, and L. J. Burgart, “Colonic ulcers accompanying collagenous colitis: implication of nonsteroidal anti-inflammatory drugs,” American Journal of Gastroenterology, vol. 98, no. 8, pp. 1834–1837, 2003. View at Publisher · View at Google Scholar · View at Scopus
  105. M. Kurien, K. E. Evans, A. D. Hopper, M. F. Hale, S. S. Cross, and D. S. Sanders, “Duodenal bulb biopsies for diagnosing adult celiac disease: is there an optimal biopsy site?” Gastrointestinal Endoscopy, vol. 75, no. 6, pp. 1190–1196, 2012. View at Publisher · View at Google Scholar · View at Scopus
  106. A. Ravelli, V. Villanacci, C. Monfredini, S. Martinazzi, V. Grassi, and S. Manenti, “How patchy is patchy villous atrophy? Distribution pattern of histological lesions in the duodenum of children with celiac disease,” American Journal of Gastroenterology, vol. 105, no. 9, pp. 2103–2110, 2010. View at Publisher · View at Google Scholar · View at Scopus
  107. A. D. Hopper, S. S. Cross, and D. S. Sanders, “Patchy villous atrophy in adult patients with suspected gluten-sensitive enteropathy: is a multiple duodenal biopsy strategy appropriate?” Endoscopy, vol. 40, no. 3, pp. 219–224, 2008. View at Publisher · View at Google Scholar · View at Scopus
  108. S. Gonzalez, A. Gupta, J. Cheng et al., “Prospective study of the role of duodenal bulb biopsies in the diagnosis of celiac disease,” Gastrointestinal Endoscopy, vol. 72, no. 4, pp. 758–765, 2010. View at Publisher · View at Google Scholar · View at Scopus
  109. R. Nenna, S. Pontone, P. Pontone et al., “Duodenal bulb in celiac adults: the ‘whether biopsying’ dilemma,” Journal of Clinical Gastroenterology, vol. 46, no. 4, pp. 302–307, 2012. View at Publisher · View at Google Scholar · View at Scopus
  110. M. Rashid and A. MacDonald, “Importance of duodenal bulb biopsies in children for diagnosis of celiac disease in clinical practice,” BMC Gastroenterology, vol. 9, article 1471, p. 78, 2009. View at Publisher · View at Google Scholar · View at Scopus
  111. G. Trynka, C. Wijmenga, and D. A. van Heel, “A genetic perspective on coeliac disease,” Trends in Molecular Medicine, vol. 16, no. 11, pp. 537–550, 2010. View at Publisher · View at Google Scholar · View at Scopus
  112. L. M. Sollid, G. Markussen, J. Ek, H. Gjerde, F. Vartdal, and E. Thorsby, “Evidence for a primary association of celiac disease to a particular HLA-DQ α/β heterodimer,” Journal of Experimental Medicine, vol. 169, no. 1, pp. 345–350, 1989. View at Publisher · View at Google Scholar · View at Scopus
  113. L. M. Sollid and E. Thorsby, “HLA susceptibility genes in celiac disease: genetic mapping and role in pathogenesis,” Gastroenterology, vol. 105, no. 3, pp. 910–922, 1993. View at Google Scholar · View at Scopus
  114. A. M. P. Montgomery, A. K. J. Goka, P. J. Kumar, M. J. G. Farthing, and M. L. Clark, “Low gluten diet in the treatment of adult coeliac disease: effect on jejunal morphology and serum anti-gluten antibodies,” Gut, vol. 29, no. 11, pp. 1564–1568, 1988. View at Publisher · View at Google Scholar · View at Scopus
  115. P. J. Kumar, D. P. O'Donoghue, K. Stenson, and A. M. Dawson, “Reintroduction of gluten in adults and children with treated coeliac disease,” Gut, vol. 20, no. 9, pp. 743–749, 1979. View at Publisher · View at Google Scholar · View at Scopus
  116. C. Catassi, M. Rossini, I.-M. Ratsch et al., “Dose dependent effects of protracted ingestion of small amounts of gliadin in coeliac disease children: A clinical and jejunal morphometric study,” Gut, vol. 34, no. 11, pp. 1515–1519, 1993. View at Publisher · View at Google Scholar · View at Scopus
  117. C. Catassi, E. Fabiani, G. Iacono et al., “A prospective, double-blind, placebo-controlled trial to establish a safe gluten threshold for patients with celiac disease,” The American Journal of Clinical Nutrition, vol. 85, no. 1, pp. 160–166, 2007. View at Google Scholar · View at Scopus
  118. P. J. Ciclitira, R. Cerio, H. J. Ellis, D. Maxton, J. M. Nelufer, and J. M. Macartney, “Evaluation of a gliadin-containing gluten-free product in coeliac patients,” Human Nutrition: Clinical Nutrition, vol. 39, no. 4, pp. 303–308, 1985. View at Google Scholar · View at Scopus
  119. D. Leffler, D. Schuppan, K. Pallav et al., “Kinetics of the histological, serological and symptomatic responses to gluten challenge in adults with coeliac disease,” Gut, vol. 62, no. 7, pp. 996–1004, 2013. View at Publisher · View at Google Scholar · View at Scopus
  120. R. P. Anderson, P. Degano, A. J. Godkin, D. P. Jewell, and A. V. S. Hill, “In vivo antigen challenge in celiac disease identifies a single transglutaminase-modified peptide as the dominant A-gliadin T-cell epitope,” Nature Medicine, vol. 6, no. 3, pp. 337–342, 2000. View at Publisher · View at Google Scholar · View at Scopus
  121. J. A. Tye-Din, J. A. Stewart, J. A. Dromey et al., “Comprehensive, quantitative mapping of T cell epitopes in gluten in celiac disease,” Science Translational Medicine, vol. 2, no. 41, pp. 41–51, 2010. View at Publisher · View at Google Scholar · View at Scopus
  122. M. Ráki, L.-E. Fallang, M. Brottveit et al., “Tetramer visualization of gut-homing gluten-specific T cells in the peripheral blood of celiac disease patients,” Proceedings of the National Academy of Sciences of the United States of America, vol. 104, no. 8, pp. 2831–2836, 2007. View at Publisher · View at Google Scholar · View at Scopus
  123. M. Brottveit, M. Ráki, E. Bergseng et al., “Assessing possible celiac disease by an HLA-DQ2-gliadin tetramer test,” The American Journal of Gastroenterology, vol. 106, no. 7, pp. 1318–1324, 2011. View at Publisher · View at Google Scholar · View at Scopus
  124. A. Camarca, G. Radano, R. Di Mase et al., “Short wheat challenge is a reproducible in-vivo assay to detect immune response to gluten,” Clinical and Experimental Immunology, vol. 169, no. 2, pp. 129–136, 2012. View at Publisher · View at Google Scholar · View at Scopus
  125. M. Y. Hardy, J. A. Tye-Din, J. A. Stewart et al., “Ingestion of oats and barley in patients with celiac disease mobilizes cross-reactive T cells activated by avenin peptides and immuno-dominant hordein peptides,” Journal of Autoimmunity, vol. 56, pp. 56–65, 2015. View at Publisher · View at Google Scholar
  126. N. Ontiveros, J. A. Tye-Din, M. Y. Hardy, and R. P. Anderson, “Ex-vivo whole blood secretion of interferon (IFN)-γ and IFN-γ-inducible protein-10 measured by enzyme-linked immunosorbent assay are as sensitive as IFN-γ enzyme-linked immunospot for the detection of gluten-reactive T cells in human leucocyte antigen (HLA)-DQ2·5+-associated coeliac disease,” Clinical and Experimental Immunology, vol. 175, no. 2, pp. 305–315, 2014. View at Publisher · View at Google Scholar · View at Scopus
  127. R. Tortora, I. Russo, G. D. de Palma et al., “In vitro gliadin challenge: diagnostic accuracy and utility for the difficult diagnosis of celiac disease,” The American Journal of Gastroenterology, vol. 107, no. 1, pp. 111–117, 2012. View at Publisher · View at Google Scholar · View at Scopus