KRAS and BRAF Mutation Detection: Is Immunohistochemistry a Possible Alternative to Molecular Biology in Colorectal Cancer?

Table 2

Contingency table for determination of KRAS mutation status using immunostaining.

	KRAS mutation status
	Wild type	Mutated	Total
KRAS immunohistochemistry status
−	14	8	22
+	8	3	11
Total	22	11	33

Sensitivity = 3/11 = 27%.
Specificity = 14/22 = 64%.