Therapeutic Targeting of Fibroblast Growth Factor Receptors in Gastric Cancer

Table 2

FGFR gene alterations in GC.

	Method		Positive expression definition	%	Relation to; clinicopathological factors	Relation to survival	Reference
FGFR2 amplification	FISH	961	FGFR2/CEP-10 ratio ≥2  or FGFR2 gene clusters in ≥10%	5.6	N	Worse	[31]
	FISH	313	FGFR2/CEP-10 ratio ≥2 or FGFR2 gene clusters	4.5	T, N, M, stage	Worse	[29]
	FISH	171	FGFR2/CEP-10 ratio ≥2	1.8	ND	Worse	[28]
	FISH	137	FGFR2/CEP-10 ratio ≥2	7.3	Undifferentiated type	Worse	[30]
	RT-PCR	267	FGFR2 >5 copies	4.1	NA	worse	[32]
	SNP microarray	193	GISTIC algorithm	9.3	NA	NA	[33]
	SNP microarray	100	GISTIC algorithm	3.0	ND	Not investigated	[34]
FGFR4 SNIP	PCR-RFLP	103	Arg388 allele	57	NA	Worse	[36]
FGFR1 mutation	Whole-exome sequence	138		2.2	ND	ND	[37]

FISH: fluorescence in situ hybridization; RT-PCR: reverse-transcription polymerase chain reaction; SNP: single nucleotide polymorphism; PCR-RFLP: polymerase chain reaction-restriction fragment length polymorphism analysis; CEP: chromosome enumeration probe; GISTIC: the genomic identification of significant targets in cancer; T: tumor depth; N: lymph-node metastasis; M: distant metastasis; NA: not assisted; ND: not described.