Therapeutic Targeting of Fibroblast Growth Factor Receptors in Gastric Cancer

Table 4

Phase III clinical trials of FGFR-targeting agents.

Agent	Target	Type of cancer	Phase	Combined regimen (comparative arm)	Status or result	Reference
Cediranib (AZD2171)	FGFR and VEGFR	CRC	III	FOLFOX or CAPOX (FOLFOX or CAPOX + placebo)	Negative on OS	[59]
		CRC	III	FOLFOX (FOLFOX + bevacizumab)	Negative on PFS	[60]
		NSLSC	III	Carboplatin + paclitaxel (carboplatin + paclitaxel + placebo)	Negative on PFS/OS	[61]
Brivanib (BMS582664)	FGFR and VEGFR	CRC (wild-type KRAS)	III	Cetuximab (cetuximab + placebo)	Negative on OS	[62]
		HCC	III	None (sorafenib)	Negative on OS	[63]
		HCC	III	None (placebo)	Negative on OS	[64]
Dovitinib (TKI258)	FGFR, VEGFR, PDGFR, FLT-3, KIT, and CSF-1	RCC	III	None (sorafenib)	Negative on PFS	[65]
Nintedanib (BIBF1120)	FGFR, VEGFR, PDGFR, FLT-3, and LCK	NSCLC	III	Docetaxel (docetaxel + placebo)	Positive on PFS	[66]
Lenvatinib (E7080)	FGFR, VEGFR, and PDGFR	HCC	III	None (sorafenib)	Ongoing	[68]
		Thyroid	III	None (placebo)	Ongoing	[69]
Orantinib (TSU68)	FGFR, VEGFR, and PDGFR	HCC	III	None (placebo)	Suspended	[70]

CRC: colorectal cancer; NSCLC: non-small-cell lung cancer; HCC: hepatocellular carcinoma; RCC: renal cell carcinoma; FOLFOX: 5-fluorouracil + leucovorin + oxaliplatin; CAPOX: capecitabine + leucovorin + oxaliplatin; RFS: relapse-free survival; OS: overall survival.