Table of Contents Author Guidelines Submit a Manuscript
Gastroenterology Research and Practice
Volume 2015 (2015), Article ID 823897, 8 pages
http://dx.doi.org/10.1155/2015/823897
Research Article

Increased Chromogranin A Cell Density in the Large Intestine of Patients with Irritable Bowel Syndrome after Receiving Dietary Guidance

1Division of Gastroenterology, Department of Medicine, Stord Hospital, 5416 Stord, Norway
2Division of Gastroenterology, Department of Clinical Medicine, University of Bergen, 5020 Bergen, Norway
3National Centre for Functional Gastrointestinal Disorders, Department of Medicine, Haukeland University Hospital, 5021 Bergen, Norway
4Department of Research, Helse-Fonna, 5528 Haugesund, Norway

Received 19 October 2014; Revised 7 February 2015; Accepted 15 February 2015

Academic Editor: Peter J. Whorwell

Copyright © 2015 Tarek Mazzawi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. M. El-Salhy, D. Gundersen, J. G. Hatlebakk, and T. Hausken, Irritable Bowel Syndrome, Nova Scientific, New York, NY, USA, 2012.
  2. M. El-Salhy, H. Østgaard, D. Gundersen, J. G. Hatlebakk, and T. Hausken, “The role of diet in the pathogenesis and management of irritable bowel syndrome (review),” International Journal of Molecular Medicine, vol. 29, no. 5, pp. 723–731, 2012. View at Publisher · View at Google Scholar · View at Scopus
  3. L. Agreus, K. Svardsudd, O. Nyren, and G. Tibblin, “Irritable bowel syndrome and dyspepsia in the general population: overlap and lack of stability over time,” Gastroenterology, vol. 109, no. 3, pp. 671–680, 1995. View at Publisher · View at Google Scholar · View at Scopus
  4. D. A. Drossman, Z. Li, E. Andruzzi et al., “U. S. Householder survey of functional gastrointestinal disorders—Prevalence, sociodemography, and health impact,” Digestive Diseases and Sciences, vol. 38, no. 9, pp. 1569–1580, 1993. View at Publisher · View at Google Scholar · View at Scopus
  5. M. El-Salhy, “Irritable bowel syndrome: diagnosis and pathogenesis,” World Journal of Gastroenterology, vol. 18, no. 37, pp. 5151–5163, 2012. View at Google Scholar
  6. W. G. Thompson and K. W. Heaton, “Functional bowel disorders in apparently healthy people,” Gastroenterology, vol. 79, no. 2, pp. 283–288, 1980. View at Google Scholar · View at Scopus
  7. M. El-Salhy, D. Gundersen, O. H. Gilja, J. G. Hatlebakk, and T. Hausken, “Is irritable bowel syndrome an organic disorder?” World Journal of Gastroenterology, vol. 20, no. 2, pp. 384–400, 2014. View at Publisher · View at Google Scholar · View at Scopus
  8. Y. J. Lee and K. S. Park, “Irritable bowel syndrome: emerging paradigm in pathophysiology,” World Journal of Gastroenterology, vol. 20, no. 10, pp. 2456–2469, 2014. View at Publisher · View at Google Scholar · View at Scopus
  9. M. Camilleri, “Physiological underpinnings of irritable bowel syndrome: neurohormonal mechanisms,” The Journal of Physiology, vol. 592, no. 14, pp. 2967–2980, 2014. View at Publisher · View at Google Scholar · View at Scopus
  10. M. El-Salhy, “The possible role of the gut neuroendocrine system in diabetes gastroenteropathy,” Histology and Histopathology, vol. 17, no. 4, pp. 1153–1161, 2002. View at Google Scholar · View at Scopus
  11. G. W. Moran, F. C. Leslie, S. E. Levison, J. Worthington, and J. T. McLaughlin, “Enteroendocrine cells: neglected players in gastrointestinal disorders?” Therapeutic Advances in Gastroenterology, vol. 1, no. 1, pp. 51–60, 2008. View at Google Scholar
  12. S. Moran-Ramos, A. R. Tovar, and N. Torres, “Diet: friend or foe of enteroendocrine cells: how it interacts with enteroendocrine cells,” Advances in Nutrition, vol. 3, no. 1, pp. 8–20, 2012. View at Publisher · View at Google Scholar · View at Scopus
  13. R. Buffa, C. Capella, P. Fontana, L. Usellini, and E. Solcia, “Types of endocrine cells in the human colon and rectum,” Cell and Tissue Research, vol. 192, no. 2, pp. 227–240, 1978. View at Publisher · View at Google Scholar · View at Scopus
  14. O. Sandström and M. El-Salhy, “Ageing and endocrine cells of human duodenum,” Mechanisms of Ageing and Development, vol. 108, no. 1, pp. 39–48, 1999. View at Publisher · View at Google Scholar · View at Scopus
  15. M. El-Salhy, “Ghrelin in gastrointestinal diseases and disorders: a possible role in the pathophysiology and clinical implications (review),” International Journal of Molecular Medicine, vol. 24, no. 6, pp. 727–732, 2009. View at Publisher · View at Google Scholar · View at Scopus
  16. G. Tolhurst, F. Reimann, and F. M. Gribble, “Intestinal sensing of nutrients,” Handbook of Experimental Pharmacology, vol. 209, pp. 309–335, 2012. View at Publisher · View at Google Scholar · View at Scopus
  17. J. Lee, B. P. Cummings, E. Martin et al., “Glucose sensing by gut endocrine cells and activation of the vagal afferent pathway is impaired in a rodent model of type 2 diabetes mellitus,” American Journal of Physiology—Regulatory Integrative and Comparative Physiology, vol. 302, no. 6, pp. R657–R666, 2012. View at Publisher · View at Google Scholar · View at Scopus
  18. H. E. Parker, F. Reimann, and F. M. Gribble, “Molecular mechanisms underlying nutrient-stimulated incretin secretion,” Expert Reviews in Molecular Medicine, vol. 12, article e1, 2010. View at Publisher · View at Google Scholar · View at Scopus
  19. H. E. Raybould, “Nutrient sensing in the gastrointestinal tract: possible role for nutrient transporters,” Journal of Physiology and Biochemistry, vol. 64, no. 4, pp. 349–356, 2008. View at Publisher · View at Google Scholar · View at Scopus
  20. A. san Gabriel, E. Nakamura, H. Uneyama, and K. Torii, “Taste, visceral information and exocrine reflexes with glutamate through umami receptors,” The Journal of Medical Investigation, vol. 56, supplement, pp. 209–217, 2009. View at Publisher · View at Google Scholar · View at Scopus
  21. T. Rudholm, B. Wallin, E. Theodorsson, E. Näslund, and P. M. Hellström, “Release of regulatory gut peptides somatostatin, neurotensin and vasoactive intestinal peptide by acid and hyperosmolal solutions in the intestine in conscious rats,” Regulatory Peptides, vol. 152, no. 1–3, pp. 8–12, 2009. View at Publisher · View at Google Scholar · View at Scopus
  22. C. Sternini, L. Anselmi, and E. Rozengurt, “Enteroendocrine cells: a site of ‘taste’ in gastrointestinal chemosensing,” Current Opinion in Endocrinology, Diabetes and Obesity, vol. 15, no. 1, pp. 73–78, 2008. View at Publisher · View at Google Scholar · View at Scopus
  23. C. Sternini, “Taste receptors in the gastrointestinal tract. IV. Functional implications of bitter taste receptors in gastrointestinal chemosensing,” American Journal of Physiology—Gastrointestinal and Liver Physiology, vol. 292, no. 2, pp. G457–G461, 2007. View at Publisher · View at Google Scholar · View at Scopus
  24. A. M. J. Buchan, “Nutrient tasting and signaling mechanisms in the gut III. Endocrine cell recognition of luminal nutrients,” American Journal of Physiology—Gastrointestinal and Liver Physiology, vol. 277, no. 6, pp. G1103–G1107, 1999. View at Google Scholar · View at Scopus
  25. M. Montero-Hadjadje, S. Elias, L. Chevalier et al., “Chromogranin A promotes peptide hormone sorting to mobile granules in constitutively and regulated secreting cells. Role of conserved N- and C-terminal peptides,” The Journal of Biological Chemistry, vol. 284, no. 18, pp. 12420–12431, 2009. View at Publisher · View at Google Scholar · View at Scopus
  26. P. Shooshtarizadeh, D. Zhang, J.-F. Chich et al., “The antimicrobial peptides derived from chromogranin/secretogranin family, new actors of innate immunity,” Regulatory Peptides, vol. 165, no. 1, pp. 102–110, 2010. View at Publisher · View at Google Scholar · View at Scopus
  27. M. El-Salhy, T. Mazzawi, D. Gundersen, and T. Hausken, “Chromogranin A cell density in the rectum of patients with irritable bowel syndrome,” Molecular Medicine Reports, vol. 6, no. 6, pp. 1223–1225, 2012. View at Publisher · View at Google Scholar · View at Scopus
  28. O. Sandström and M. El-Salhy, “Human rectal endocrine cells and aging,” Mechanisms of Ageing and Development, vol. 108, no. 3, pp. 219–226, 1999. View at Publisher · View at Google Scholar · View at Scopus
  29. K. Sjolund, G. Sanden, R. Hakanson, and F. Sundler, “Endocrine cells in human intestine: an immunocytochemical study,” Gastroenterology, vol. 85, no. 5, pp. 1120–1130, 1983. View at Google Scholar · View at Scopus
  30. L. Taupenot, K. L. Harper, and D. T. O'Connor, “The chromogranin-secretogranin family,” The New England Journal of Medicine, vol. 348, no. 12, pp. 1134–1149, 2003. View at Publisher · View at Google Scholar · View at Scopus
  31. B. Wiedenmann and W. B. Huttner, “Synaptophysin and chromogranins/secretogranins—widespread constituents of distinct types of neuroendocrine vesicles and new tools in tumor diagnosis,” Virchows Archiv B: Cell Pathology Including Molecular Pathology, vol. 58, no. 2, pp. 95–121, 1989. View at Publisher · View at Google Scholar · View at Scopus
  32. L. J. Deftos, “Chromogranin A: its role in endocrine function and as an endocrine and neuroendocrine tumor marker,” Endocrine Reviews, vol. 12, no. 2, pp. 181–187, 1991. View at Publisher · View at Google Scholar · View at Scopus
  33. M. El-Salhy, B. Lomholt-Beck, and T. Hausken, “Chromogranin a as a possible tool in the diagnosis of irritable bowel syndrome,” Scandinavian Journal of Gastroenterology, vol. 45, no. 12, pp. 1435–1439, 2010. View at Publisher · View at Google Scholar · View at Scopus
  34. M. El-Salhy, J. G. Hatlebakk, O. H. Gilja, and T. Hausken, “Irritable bowel syndrome: recent developments in diagnosis, pathophysiology, and treatment,” Expert Review of Gastroenterology & Hepatology, vol. 8, no. 4, pp. 435–443, 2014. View at Publisher · View at Google Scholar · View at Scopus
  35. M. El-Salhy, “Endocrine cells in the oxyntic mucosa of the stomach in patients with irritable bowel syndrome,” World Journal of Gastrointestinal Endoscopy, vol. 6, no. 5, pp. 176–185, 2014. View at Publisher · View at Google Scholar
  36. M. El-Salhy, J. G. Hatlebakk, O. H. Gilja, and T. Hausken, “Irritable bowel syndrome: recent developments in diagnosis, pathophysiology, and treatment,” Expert Review of Gastroenterology and Hepatology, vol. 8, no. 4, pp. 435–443, 2014. View at Publisher · View at Google Scholar · View at Scopus
  37. M. Simrén, A. Månsson, A. M. Langkilde et al., “Food-related gastrointestinal symptoms in the irritable bowel syndrome,” Digestion, vol. 63, no. 2, pp. 108–115, 2001. View at Publisher · View at Google Scholar · View at Scopus
  38. E. A. Williams, X. Nai, and B. M. Corfe, “Dietary intakes in people with irritable bowel syndrome,” BMC Gastroenterology, vol. 11, article 9, 2011. View at Publisher · View at Google Scholar · View at Scopus
  39. T. Mazzawi, T. Hausken, D. Gundersen, and E.-S. Magdy, “Effects of dietary guidance on the symptoms, quality of life and habitual dietary intake of patients with irritable bowel syndrome,” Molecular Medicine Reports, vol. 8, no. 3, pp. 845–852, 2013. View at Publisher · View at Google Scholar · View at Scopus
  40. H. Østgaard, T. Hausken, D. Gundersen, and M. El-Salhy, “Diet and effects of diet management on quality of life and symptoms in patients with irritable bowel syndrome,” Molecular Medicine Reports, vol. 5, no. 6, pp. 1382–1390, 2012. View at Publisher · View at Google Scholar · View at Scopus
  41. T. Mazzawi, D. Gundersen, T. Hausken, and M. El-Salhy, “Increased gastric chromogranin A cell density following changes to diets of patients with irritable bowel syndrome,” Molecular Medicine Reports, vol. 10, no. 5, pp. 2322–2326, 2014. View at Google Scholar
  42. T. Mazzawi, T. Hausken, D. Gundersen, and M. El-Salhy, “Effect of dietary management on the gastric endocrine cells in patients with irritable bowel syndrome,” European Journal of Clinical Nutrition, 2014. View at Publisher · View at Google Scholar
  43. L. F. Masson, G. McNeill, J. O. Tomany et al., “Statistical approaches for assessing the relative validity of a food-frequency questionnaire: use of correlation coefficients and the kappa statistic,” Public Health Nutrition, vol. 6, no. 3, pp. 313–321, 2003. View at Publisher · View at Google Scholar · View at Scopus
  44. A. L. Brantsaeter, M. Haugen, J. Alexander, and H. M. Meltzer, “Validity of a new food frequency questionnaire for pregnant women in the Norwegian Mother and Child Cohort Study (MoBa),” Maternal and Child Nutrition, vol. 4, no. 1, pp. 28–43, 2008. View at Publisher · View at Google Scholar · View at Scopus
  45. P. Enck, S. Klosterhalfen, and W. Kruis, “Determination of placebo effect in irritable bowel syndrome,” Deutsche Medizinische Wochenschrift, vol. 130, no. 34-35, pp. 1934–1937, 2005. View at Publisher · View at Google Scholar · View at Scopus
  46. H. Abdul-Baki, I. I. El Hajj, L. Elzahabi et al., “A randomized controlled trial of imipramine in patients with irritable bowel syndrome,” World Journal of Gastroenterology, vol. 15, no. 29, pp. 3636–3642, 2009. View at Publisher · View at Google Scholar · View at Scopus
  47. K. A. Zernicke, T. S. Campbell, P. K. Blustein et al., “Mindfulness-based stress reduction for the treatment of irritable bowel syndrome symptoms: a randomized wait-list controlled trial,” International Journal of Behavioral Medicine, vol. 20, no. 3, pp. 385–396, 2013. View at Publisher · View at Google Scholar · View at Scopus
  48. E. P. Halmos, V. A. Power, S. J. Shepherd, P. R. Gibson, and J. G. Muir, “A diet low in FODMAPs reduces symptoms of irritable bowel syndrome,” Gastroenterology, vol. 146, no. 1, pp. 67–75, 2014. View at Publisher · View at Google Scholar · View at Scopus
  49. W. I. Khan and J. E. Ghia, “Gut hormones: emerging role in immune activation and inflammation,” Clinical & Experimental Immunology, vol. 161, no. 1, pp. 19–27, 2010. View at Publisher · View at Google Scholar · View at Scopus
  50. J. Valeur, A. M. Milde, K. B. Helle, and A. Berstad, “Low serum chromogranin a in patients with self-reported food hypersensitivity,” Scandinavian Journal of Gastroenterology, vol. 43, no. 11, pp. 1403–1404, 2008. View at Publisher · View at Google Scholar · View at Scopus
  51. K. B. Helle, A. Corti, M.-H. Metz-Boutigue, and B. Tota, “The endocrine role for chromogranin A: a prohormone for peptides with regulatory properties,” Cellular and Molecular Life Sciences, vol. 64, no. 22, pp. 2863–2886, 2007. View at Publisher · View at Google Scholar · View at Scopus
  52. M. Hocker and B. Wiedenmann, “Molecular mechanisms of enteroendocrine differentiation,” Annals of the New York Academy of Sciences, vol. 859, pp. 160–174, 1998. View at Publisher · View at Google Scholar
  53. H. Inokuchi, S. Fujimoto, and K. Kawai, “Cellular kinetics of gastrointestinal mucosa, with special reference to gut endocrine cells,” Archivum Histologicum Japonicum, vol. 46, no. 2, pp. 137–157, 1983. View at Google Scholar · View at Scopus
  54. M. El-Salhy, O. H. Gilja, D. Gundersen, J. G. Hatlebakk, and T. Hausken, “Interaction between ingested nutrients and gut endocrine cells in patients with irritable bowel syndrome (review),” International Journal of Molecular Medicine, vol. 34, no. 2, pp. 363–371, 2014. View at Publisher · View at Google Scholar