Research Article
The Anti-Inflammatory Activity of a Novel Fused-Cyclopentenone Phosphonate and Its Potential in the Local Treatment of Experimental Colitis
Figure 4
The attenuating effect of P-5 on the secretion of IL-6, IL-1α, INFγ, MCP-1, MIP-1α, and RANTES in LPS-activated macrophages. Results are expressed as the fraction (in %) of the cytokine level secreted by untreated activated cells. N: naive control; U: untreated control. Shown are the mean results ± S.D. ( = 3-4). ANOVA of the effect of P-5 at a series of concentrations on IL-6 levels was F7,33 = 115.36, , on IL-1α was F6,20 = 8.06, , on INFγ was F6,19 = 4.64, , on MCP-1 was F6,20 = 73.57, , on MIP-1α was F7,23 = 219.00, , and on RANTES was F5,17 = 100.54, . ; ; compared to untreated cells.
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