The Anti-Inflammatory Activity of a Novel Fused-Cyclopentenone Phosphonate and Its Potential in the Local Treatment of Experimental Colitis

Table 1

The effect of P-5 and 5-ASA on induced colitis, as assessed by measuring colon weight and ulceration scoring.

Group	Colon weight; (mg/kg body weight)	Ulcer severity scoring
Healthy	4.3 ± 0.6	0
DNBS-induced, untreated	8.3 ± 1.9	1.9 ± 0.7
P-5 (10 mg/kg)	5.6 ± 0.5	0.2 ± 0.4
5-ASA (268 mg/kg)	4.7 ± 0.7	0.3 ± 0.4

Shown are the mean ± S.D. values of 5–10 rats.