Table of Contents Author Guidelines Submit a Manuscript
Gastroenterology Research and Practice
Volume 2015, Article ID 946359, 8 pages
http://dx.doi.org/10.1155/2015/946359
Research Article

Correlations of Human Epithelial Growth Factor Receptor 2 Overexpression with MUC2, MUC5AC, MUC6, p53, and Clinicopathological Characteristics in Gastric Cancer Patients with Curative Resection

1Department of Surgery, Kosin University College of Medicine, 34 Amnam-dong, Seo-gu, Busan 602-703, Republic of Korea
2Department of Pathology, Kosin University College of Medicine, 34 Amnam-dong, Seo-gu, Busan 602-703, Republic of Korea

Received 9 July 2014; Revised 29 September 2014; Accepted 18 October 2014

Academic Editor: Zhongxia Wang

Copyright © 2015 Kwang Kuk Park et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. D. J. Slamon, G. M. Clark, S. G. Wong, W. J. Levin, A. Ullrich, and W. L. McGuire, “Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene,” Science, vol. 235, no. 4785, pp. 177–182, 1987. View at Publisher · View at Google Scholar · View at Scopus
  2. J. D. Barros-Silva, D. Leitão, L. Afonso et al., “Association of ERBB2 gene status with histopathological parameters and disease-specific survival in gastric carcinoma patients,” British Journal of Cancer, vol. 100, no. 3, pp. 487–493, 2009. View at Publisher · View at Google Scholar · View at Scopus
  3. J. T. Jørgensen, “Targeted HER2 treatment in advanced gastric cancer,” Oncology, vol. 78, no. 1, pp. 26–33, 2010. View at Publisher · View at Google Scholar · View at Scopus
  4. M. Nakajima, H. Sawada, Y. Yamada et al., “The prognostic significance of amplification and overexpression of c-met and c-erb B-2 in human gastric carcinomas,” Cancer, vol. 85, no. 9, pp. 1894–1902, 1999. View at Publisher · View at Google Scholar
  5. D. I. Park, J. W. Yun, J. H. Park et al., “HER-2/neu amplification is an independent prognostic factor in gastric cancer,” Digestive Diseases and Sciences, vol. 51, no. 8, pp. 1371–1379, 2006. View at Publisher · View at Google Scholar · View at Scopus
  6. M. Tanner, M. Hollmén, T. T. Junttila et al., “Amplification of HER-2 in gastric carcinoma: association with Topoisomerase IIalpha gene amplification, intestinal type, poor prognosis and sensitivity to trastuzumab,” Annals of Oncology, vol. 16, no. 2, pp. 273–278, 2005. View at Publisher · View at Google Scholar · View at Scopus
  7. G. Z. Yu, Y. Chen, and J. J. Wang, “Overexpression of Grb2/HER2 signaling in Chinese gastric cancer: their relationship with clinicopathological parameters and prognostic significance,” Journal of Cancer Research and Clinical Oncology, vol. 135, no. 10, pp. 1331–1339, 2009. View at Publisher · View at Google Scholar · View at Scopus
  8. J. T. Jorgensen and M. Hersom, “HER2 as a prognostic marker in gastric cancer: a systematic analysis of data from the literature,” Journal of Cancer, vol. 3, no. 1, pp. 137–144, 2012. View at Publisher · View at Google Scholar · View at Scopus
  9. Y.-J. Bang, E. van Cutsem, A. Feyereislova et al., “Trastuzumab in combination with chemotherapy versus chemotherapy alone for treatment of HER2-positive advanced gastric or gastro-oesophageal junction cancer (ToGA): a phase 3, open-label, randomised controlled trial,” The Lancet, vol. 376, no. 9742, pp. 687–697, 2010. View at Publisher · View at Google Scholar · View at Scopus
  10. M. Horner, L. Ries, M. Krapcho et al., SEER Cancer Statistics Review, 1975–2006, National Cancer Institute, Bethesda, Md, USA, 2009.
  11. M. A. Hollingsworth and B. J. Swanson, “Mucins in cancer: protection and control of the cell surface,” Nature Reviews Cancer, vol. 4, no. 1, pp. 45–60, 2004. View at Publisher · View at Google Scholar · View at Scopus
  12. M. C. Rose and J. A. Voynow, “Respiratory tract mucin genes and mucin glycoproteins in health and disease,” Physiological Reviews, vol. 86, no. 1, pp. 245–278, 2006. View at Publisher · View at Google Scholar · View at Scopus
  13. S. Yonezawa, M. Higashi, N. Yamada et al., “Mucins in human neoplasms: clinical pathology, gene expression and diagnostic application,” Pathology International, vol. 61, no. 12, pp. 697–716, 2011. View at Publisher · View at Google Scholar · View at Scopus
  14. P. D. Vermeer, L. A. Einwalter, T. O. Moninger et al., “Segregation of receptor and ligand regulates activation of epithelial growth factor receptor,” Nature, vol. 422, no. 6929, pp. 322–326, 2003. View at Publisher · View at Google Scholar · View at Scopus
  15. S. B. Ho, L. L. Shekels, N. W. Toribara et al., “Mucin gene expression in normal, preneoplastic, and neoplastic human gastric epithelium,” Cancer Research, vol. 55, no. 12, pp. 2681–2690, 1995. View at Google Scholar · View at Scopus
  16. B. Kocer, A. Soran, G. Kiyak et al., “Prognostic significance of mucin expression in gastric carcinoma,” Digestive Diseases and Sciences, vol. 49, no. 6, pp. 954–964, 2004. View at Publisher · View at Google Scholar · View at Scopus
  17. K. Wakatsuki, Y. Yamada, M. Narikiyo et al., “Clinicopathological and prognostic significance of mucin phenotype in gastric cancer,” Journal of Surgical Oncology, vol. 98, no. 2, pp. 124–129, 2008. View at Publisher · View at Google Scholar · View at Scopus
  18. H. Yokozaki, H. Kuniyasu, Y. Kitadai et al., “p53 point mutations in primary human gastric carcinomas,” Journal of Cancer Research and Clinical Oncology, vol. 119, no. 2, pp. 67–70, 1992. View at Publisher · View at Google Scholar · View at Scopus
  19. M. S. Al-Moundhri, V. Nirmala, I. Al-Hadabi et al., “The prognostic significance of p53, p27kip1, p21waf1, HER-2/neu, and Ki67 proteins expression in gastric cancer: a clinicopathological and immunohistochemical study of 121 Arab patients,” Journal of Surgical Oncology, vol. 91, no. 4, pp. 243–252, 2005. View at Publisher · View at Google Scholar · View at Scopus
  20. M. Hollstein, K. Rice, M. S. Greenblatt et al., “Database of p53 gene somatic mutations in human tumors and cell lines,” Nucleic Acids Research, vol. 22, no. 17, pp. 3551–3555, 1994. View at Google Scholar · View at Scopus
  21. K. E. Lee, H.-J. Lee, Y. H. Kim et al., “Prognostic significance of p53, nm23, PCNA and c-erbB-2 in gastric cancer,” Japanese Journal of Clinical Oncology, vol. 33, no. 4, pp. 173–179, 2003. View at Publisher · View at Google Scholar · View at Scopus
  22. S. B. Edge and C. C. Compton, “The American Joint Committee on Cancer: the 7th edition of the AJCC cancer staging manual and the future of TNM,” Annals of Surgical Oncology, vol. 17, no. 6, pp. 1471–1474, 2010. View at Publisher · View at Google Scholar · View at Scopus
  23. F. T. Bosman, W. H. Organization, F. Carneiro, and R. H. Hruban, WHO Classification of Tumours of the Digestive System, International Agency for Research on Cancer (IARC) (UN), 2010.
  24. Y. Toda, K. Kono, H. Abiru et al., “Application of tyramide signal amplification system to immunohistochemistry: a potent method to localize antigens that are not detectable by ordinary method,” Pathology International, vol. 49, no. 5, pp. 479–483, 1999. View at Publisher · View at Google Scholar · View at Scopus
  25. H. M. Ismail, M. Moneer, M. El-Baradie, O. Khorshid, and A. Touny, “Clinicopathologic and prognostic significance of overexpression of her-2/neu and p53 oncoproteins in gastric carcinoma using tissue microarray,” Journal of the Egyptian National Cancer Institute, vol. 19, no. 2, pp. 147–157, 2007. View at Google Scholar · View at Scopus
  26. A. L. Schechter, D. F. Stern, L. Vaidyanathan et al., “The neu oncogene: an erb-B-related gene encoding a 185,000-M(r) tumour antigen,” Nature, vol. 312, no. 5994, pp. 513–516, 1984. View at Publisher · View at Google Scholar · View at Scopus
  27. R. Haddad, A. D. Colevas, J. F. Krane et al., “Herceptin in patients with advanced or metastatic salivary gland carcinomas. A phase II study,” Oral Oncology, vol. 39, no. 7, pp. 724–727, 2003. View at Publisher · View at Google Scholar · View at Scopus
  28. D. E. Hansel, R. Ashfaq, A. Rahman et al., “A subset of pancreatic adenocarcinomas demonstrates coamplification of topoisomerase IIα and HER2/neu: use of immunolabeling and multicolor FISH for potential patient screening and treatment,” The American Journal of Clinical Pathology, vol. 123, no. 1, pp. 28–35, 2005. View at Publisher · View at Google Scholar · View at Scopus
  29. Z. Latif, A. D. Watters, J. M. S. Bartlett, M. A. Underwood, and M. Aitchison, “Gene amplification and over-expression of HER2 in renal cell carcinoma,” BJU International, vol. 89, no. 1, pp. 5–9, 2002. View at Publisher · View at Google Scholar · View at Scopus
  30. Z. Latif, A. D. Watters, I. Dunn, K. Grigor, M. A. Underwood, and J. M. S. Bartlett, “HER2/neu gene amplification and protein overexpression in G3 pT2 transitional cell carcinoma of the bladder: a role for anti-HER2 therapy?” European Journal of Cancer, vol. 40, no. 1, pp. 56–63, 2004. View at Publisher · View at Google Scholar · View at Scopus
  31. B. Leyland-Jones, “Trastuzumab therapy for the metastatic patient: does the primary match?” Annals of Oncology, vol. 13, no. 7, pp. 993–994, 2002. View at Publisher · View at Google Scholar · View at Scopus
  32. J. D. Oxley, M. H. Winkler, D. A. Gillatt, and D. S. Peat, “Her-2/neu oncogene amplification in clinically localised prostate cancer,” Journal of Clinical Pathology, vol. 55, no. 2, pp. 118–120, 2002. View at Publisher · View at Google Scholar · View at Scopus
  33. J. S. Ross and B. J. McKenna, “The HER-2/neu oncogene in tumors of the gastrointestinal tract,” Cancer Investigation, vol. 19, no. 5, pp. 554–568, 2001. View at Publisher · View at Google Scholar · View at Scopus
  34. C. Tapia, S. Savic, U. Wagner et al., “HER2 gene status in primary breast cancers and matched distant metastases,” Breast Cancer Research, vol. 9, no. 3, article R31, 2007. View at Publisher · View at Google Scholar · View at Scopus
  35. K. Ugocsai, L. Mándoky, L. Tiszlavicz, and J. Molnár, “Investigation of HER2 overexpression in non-small cell lung cancer,” Anticancer Research, vol. 25, no. 4, pp. 3061–3066, 2005. View at Google Scholar · View at Scopus
  36. A. J. Levine, “p53, the cellular gatekeeper for growth and division,” Cell, vol. 88, no. 3, pp. 323–331, 1997. View at Publisher · View at Google Scholar · View at Scopus
  37. C. B. Moelans, A. N. Milne, F. H. Morsink, G. J. A. Offerhaus, and P. J. van Diest, “Low frequency of HER2 amplification and overexpression in early onset gastric cancer,” Cellular Oncology, vol. 34, no. 2, pp. 89–95, 2011. View at Publisher · View at Google Scholar · View at Scopus
  38. M. Oren, “Lonely no more: p53 finds its kin in a tumor suppressor haven,” Cell, vol. 90, no. 5, pp. 829–832, 1997. View at Publisher · View at Google Scholar · View at Scopus
  39. K. Sakai, S. Mori, T. Kawamoto et al., “Expression of epidermal growth factor receptors on normal human gastric epithelia and gastric carcinomas,” Journal of the National Cancer Institute, vol. 77, no. 5, pp. 1047–1052, 1986. View at Google Scholar · View at Scopus
  40. W. Q. Sheng, D. Huang, J. M. Ying et al., “HER2 status in gastric cancers: a retrospective analysis from four Chinese representative clinical centers and assessment of its prognostic significance,” Annals of Oncology, vol. 24, no. 9, Article ID mdt232, pp. 2360–2364, 2013. View at Publisher · View at Google Scholar · View at Scopus
  41. J. E. Boers, H. Meeuwissen, and N. Methorst, “HER2 status in gastro-oesophageal adenocarcinomas assessed by two rabbit monoclonal antibodies (SP3 and 4B5) and two in situ hybridization methods (FISH and SISH),” Histopathology, vol. 58, no. 3, pp. 383–394, 2011. View at Publisher · View at Google Scholar · View at Scopus
  42. S.-A. Im, J. W. Kim, J.-S. Kim et al., “Clinicopathologic characteristics of patients with stage III/IV (M0) advanced gastric cancer, according to HER2 status assessed by immunohistochemistry and fluorescence in situ hybridization,” Diagnostic Molecular Pathology, vol. 20, no. 2, pp. 94–100, 2011. View at Publisher · View at Google Scholar · View at Scopus
  43. M. A. Kim, E. J. Jung, H. S. Lee et al., “Evaluation of HER-2 gene status in gastric carcinoma using immunohistochemistry, fluorescence in situ hybridization, and real-time quantitative polymerase chain reaction,” Human Pathology, vol. 38, no. 9, pp. 1386–1393, 2007. View at Publisher · View at Google Scholar · View at Scopus
  44. P. L. Kunz, A. Mojtahed, G. A. Fisher et al., “HER2 expression in gastric and gastroesophageal junction adenocarcinoma in a US population: clinicopathologic analysis with proposed approach to HER2 assessment,” Applied Immunohistochemistry and Molecular Morphology, vol. 20, no. 1, pp. 13–24, 2012. View at Publisher · View at Google Scholar · View at Scopus
  45. A. H. Marx, L. Tharun, J. Muth et al., “HER-2 amplification is highly homogenous in gastric cancer,” Human Pathology, vol. 40, no. 6, pp. 769–777, 2009. View at Publisher · View at Google Scholar · View at Scopus
  46. B. Yan, E. X. Yau, S. S. B. Omar et al., “A study of HER2 gene amplification and protein expression in gastric cancer,” Journal of Clinical Pathology, vol. 63, no. 9, pp. 839–842, 2010. View at Publisher · View at Google Scholar · View at Scopus
  47. S. Y. Yan, Y. Hu, J. G. Fan et al., “Clinicopathologic significance of HER-2/neu protein expression and gene amplification in gastric carcinoma,” World Journal of Gastroenterology, vol. 17, no. 11, pp. 1501–1506, 2011. View at Publisher · View at Google Scholar · View at Scopus
  48. K. C. Kim, Y. W. Koh, H.-M. Chang et al., “Evaluation of HER2 protein expression in gastric carcinomas: comparative analysis of 1414 cases of whole-tissue sections and 595 cases of tissue microarrays,” Annals of Surgical Oncology, vol. 18, no. 10, pp. 2833–2840, 2011. View at Publisher · View at Google Scholar · View at Scopus
  49. R. Seshadri, D. J. Horsfall, F. Firgaira et al., “The relative prognostic significance of total cathepsin D and HER-2/neu oncogene amplification in breast cancer,” International Journal of Cancer, vol. 56, no. 1, pp. 61–65, 1994. View at Google Scholar · View at Scopus
  50. S. Toikkanen, H. Helin, J. Isola, and H. Joensuu, “Prognostic significance of HER-2 oncoprotein expression in breast cancer: a 30-year follow-up,” Journal of Clinical Oncology, vol. 10, no. 7, pp. 1044–1048, 1992. View at Google Scholar · View at Scopus
  51. H. Allgayer, R. Babic, K. U. Gruetzner, A. Tarabichi, F. W. Schildberg, and M. M. Heiss, “c-erbB-2 is of independent prognostic relevance in gastric cancer and is associated with the expression of tumor-associated protease systems,” Journal of Clinical Oncology, vol. 18, no. 11, pp. 2201–2209, 2000. View at Google Scholar · View at Scopus
  52. H. Grabsch, S. Sivakumar, S. Gray, H. E. Gabbert, and W. Müller, “HER2 expression in gastric cancer: rare, heterogeneous and of no prognostic value-conclusions from 924 cases of two independent series,” Cellular Oncology, vol. 32, no. 1-2, pp. 57–65, 2010. View at Publisher · View at Google Scholar · View at Scopus
  53. H. R. Lee, J.-H. Kim, H. D. Uhm et al., “Overexpression of c-ErbB-2 protein in gastric cancer by immunohistochemical stain,” Oncology, vol. 53, no. 3, pp. 192–197, 1996. View at Publisher · View at Google Scholar · View at Scopus
  54. J. Pinto-de-Sousa, L. David, R. Almeida et al., “c-erb B-2 expression is associated with tumor location and venous invasion and influences survival of patients with gastric carcinoma,” International Journal of Surgical Pathology, vol. 10, no. 4, pp. 247–256, 2002. View at Publisher · View at Google Scholar · View at Scopus
  55. H. Sasano, F. Date, A. Imatani, S. Asaki, and H. Nagura, “Double immunostaining for c-erbB-2 and p53 in human stomach cancer cells,” Human Pathology, vol. 24, no. 6, pp. 584–589, 1993. View at Publisher · View at Google Scholar · View at Scopus
  56. C.-T. Shun, M.-S. Wu, J.-T. Lin et al., “Relationship of p53 and c-erbB-2 expression to histopathological features, Helicobacter pylori infection and prognosis in gastric cancer,” Hepato-Gastroenterology, vol. 44, no. 14, pp. 604–609, 1997. View at Google Scholar · View at Scopus
  57. M. Tateishi, T. Toda, Y. Minamisono, and S. Nagasaki, “Clinicopathological significance of c-erbB-2 protein expression in human gastric carcinoma,” Journal of Surgical Oncology, vol. 49, no. 4, pp. 209–212, 1992. View at Publisher · View at Google Scholar · View at Scopus
  58. S. Uchino, H. Tsuda, K. Maruyama et al., “Overexpression of c-erbB-2 protein in gastric cancer. Its correlation with long-term survival of patients,” Cancer, vol. 72, no. 11, pp. 3179–3184, 1993. View at Google Scholar
  59. Y. Yonemura, I. Ninomiya, A. Yamaguchi et al., “Evaluation of immunoreactivity for erbB-2 protein as a marker of poor short term prognosis in gastric cancer,” Cancer Research, vol. 51, no. 3, pp. 1034–1038, 1991. View at Google Scholar · View at Scopus
  60. X. L. Zhang, Y. S. Yang, D. P. Xu et al., “Comparative study on overexpression of Her2/Neu and Her3 in gastric cancer,” World Journal of Surgery, vol. 33, no. 10, pp. 2112–2118, 2009. View at Publisher · View at Google Scholar · View at Scopus
  61. Y. Yonemura, I. Ninomiya, S. Ohoyama et al., “Correlation of c-erbB-2 protein expression and lymph node status in early gastric cancer,” Oncology, vol. 49, no. 5, pp. 363–367, 1992. View at Publisher · View at Google Scholar · View at Scopus
  62. C. Gómez-Martin, E. Garralda, M. José Echarri et al., “HER2/neu testing for anti-HER2-based therapies in patients with unresectable and/or metastatic gastric cancer,” Journal of Clinical Pathology, vol. 65, no. 8, pp. 751–757, 2012. View at Publisher · View at Google Scholar · View at Scopus
  63. S. Jain, M. I. Filipe, W. J. Gullick, J. Linehan, and R. W. Morris, “c-erbB-2 proto-oncogene expression and its relationship to survival in gastric carcinoma: an immunohistochemical study on archival material,” International Journal of Cancer, vol. 48, no. 5, pp. 668–671, 1991. View at Publisher · View at Google Scholar · View at Scopus
  64. T. Hernandez-Boussard, P. Rodriguez-Tome, R. Montesano, and P. Hainaut, “IARC p53 mutation database: a relational database to compile and analyze p53 mutations in human tumors and cell lines. International Agency for Research on Cancer,” Human Mutation, vol. 14, no. 1, pp. 1–8, 1999. View at Google Scholar
  65. T. Matozaki, C. Sakamoto, T. Suzuki et al., “p53 gene mutations in human gastric cancer: Wild-type p53 but not mutant p53 suppresses growth of human gastric cancer cells,” Cancer Research, vol. 52, no. 16, pp. 4335–4341, 1992. View at Google Scholar · View at Scopus