Correlations of Human Epithelial Growth Factor Receptor 2 Overexpression with MUC2, MUC5AC, MUC6, p53, and Clinicopathological Characteristics in Gastric Cancer Patients with Curative Resection

Table 1

Correlation between HER2 overexpression and clinicopathologic parameters of gastric carcinoma.

Variables	(%)	HER2 positive		value
		Positive (%); ()	Negative (%); ()
Age^a	60.51 ± 10.86	59.70 ± 9.85	60.68 ± 11.07	0.540
Gender				0.546
Male	187 (66.3)	34 (18.2%)	153 (81.8%)
Female	95 (33.7)	17 (17.9%)	78 (82.1%)
Location				0.173
Upper	45 (16.0)	12 (26.7%)	33 (73.7%)
Middle	71 (25.2)	8 (11.3%)	63 (88.7%)
Lower	164 (58.2)	31 (18.9%)	133 (81.1%)
EGJ^b	4 (1.2)	1 (25.0%)	3 (75.0%)
WHO classification				0.022
Tubular	167 (60.9)	32 (19.2%)	135 (80.8%)
Mucinous	1 (0.4)	0 (0.0%)	1 (100.0%)
Poorly cohesive	106 (37.6)	15 (14.2%)	91 (85.8%)
Papillary	6 (2.1)	2 (33.3%)	4 (66.7%)
Lauren classification				0.010
Intestinal	150 (53.2)	36 (24.0%)	114 (76.0%)
Diffuse	86 (30.5)	12 (14.0%)	74 (86.0%)
Mixed	39 (13.8)	1 (2.6%)	38 (97.4%)
Indeterminate	7 (2.5)	2 (28.6%)	5 (71.4%)
Size^a	3.48 ± 3.06	3.87 ± 3.15	3.40 ± 3.04	0.293
Tumor size				0.176
5 cm <	61 (21.6)	14 (23.0%)	47 (77.0%)
5 cm ≥	221 (78.4)	37 (16.7%)	184 (83.3%)
Depth of tumor (T stage)				0.036
T1a	138 (48.9)	20 (14.5%)	118 (85.5%)
T1b	37 (13.1)	9 (24.3%)	28 (75.7%)
T2	15 (5.3)	1 (6.7%)	14 (93.3%)
T3	55 (19.5)	9 (16.4%)	46 (83.6%)
T4a	36 (12.8)	11 (30.6%)	25 (69.4%)
T4b	1 (0.4)	1 (100.0)	0 (0.0)
Nodal stage (N)				0.003
N0	182 (64.5)	24 (13.2%)	158 (86.8%)
N1	30 (10.6)	4 (13.3%)	26 (86.7%)
N2	33 (11.7)	10 (30.3%)	23 (69.7%)
N3	37 (13.1)	13 (35.1%)	24 (64.9%)
Stage (TNM)				0.027
I	158 (56.0)	22 (13.9%)	136 (86.1%)
II	63 (22.3)	11 (17.5%)	52 (82.5%)
III	61 (21.7)	18 (29.5%)	43 (70.5%)
Neural invasion				0.345
Yes	56 (21.0)	8 (14.3%)	48 (85.7%)
No	211 (79.0)	43 (20.4%)	168 (79.6%)
Lymphatic invasion				0.011
Yes	83 (31.1)	24 (28.9%)	59 (71.1%)
No	184 (68.9)	27 (14.7%)	157 (85.3%)
Vascular invasion				0.105
Yes	14 (5.2)	5 (35.7%)	9 (64.3%)
No	253 (94.8)	46 (18.2%)	207 (81.8%)
Recurrence				0.005
Yes	31 (11.0)	12 (38.7%)	19 (61.3%)
No	251 (89.0)	39 (15.5%)	212 (84.5%)

Age and size were reported as the mean ± SD.
^bEsophagogastric junction.