Correlations of Human Epithelial Growth Factor Receptor 2 Overexpression with MUC2, MUC5AC, MUC6, p53, and Clinicopathological Characteristics in Gastric Cancer Patients with Curative Resection
Table 1
Correlation between HER2 overexpression and clinicopathologic parameters of gastric carcinoma.
Variables
(%)
HER2 positive
value
Positive (%) ()
Negative (%) ()
Agea
60.51 ± 10.86
59.70 ± 9.85
60.68 ± 11.07
0.540
Gender
0.546
Male
187 (66.3)
34 (18.2%)
153 (81.8%)
Female
95 (33.7)
17 (17.9%)
78 (82.1%)
Location
0.173
Upper
45 (16.0)
12 (26.7%)
33 (73.7%)
Middle
71 (25.2)
8 (11.3%)
63 (88.7%)
Lower
164 (58.2)
31 (18.9%)
133 (81.1%)
EGJb
4 (1.2)
1 (25.0%)
3 (75.0%)
WHO classification
0.022
Tubular
167 (60.9)
32 (19.2%)
135 (80.8%)
Mucinous
1 (0.4)
0 (0.0%)
1 (100.0%)
Poorly cohesive
106 (37.6)
15 (14.2%)
91 (85.8%)
Papillary
6 (2.1)
2 (33.3%)
4 (66.7%)
Lauren classification
0.010
Intestinal
150 (53.2)
36 (24.0%)
114 (76.0%)
Diffuse
86 (30.5)
12 (14.0%)
74 (86.0%)
Mixed
39 (13.8)
1 (2.6%)
38 (97.4%)
Indeterminate
7 (2.5)
2 (28.6%)
5 (71.4%)
Sizea
3.48 ± 3.06
3.87 ± 3.15
3.40 ± 3.04
0.293
Tumor size
0.176
5 cm <
61 (21.6)
14 (23.0%)
47 (77.0%)
5 cm ≥
221 (78.4)
37 (16.7%)
184 (83.3%)
Depth of tumor (T stage)
0.036
T1a
138 (48.9)
20 (14.5%)
118 (85.5%)
T1b
37 (13.1)
9 (24.3%)
28 (75.7%)
T2
15 (5.3)
1 (6.7%)
14 (93.3%)
T3
55 (19.5)
9 (16.4%)
46 (83.6%)
T4a
36 (12.8)
11 (30.6%)
25 (69.4%)
T4b
1 (0.4)
1 (100.0)
0 (0.0)
Nodal stage (N)
0.003
N0
182 (64.5)
24 (13.2%)
158 (86.8%)
N1
30 (10.6)
4 (13.3%)
26 (86.7%)
N2
33 (11.7)
10 (30.3%)
23 (69.7%)
N3
37 (13.1)
13 (35.1%)
24 (64.9%)
Stage (TNM)
0.027
I
158 (56.0)
22 (13.9%)
136 (86.1%)
II
63 (22.3)
11 (17.5%)
52 (82.5%)
III
61 (21.7)
18 (29.5%)
43 (70.5%)
Neural invasion
0.345
Yes
56 (21.0)
8 (14.3%)
48 (85.7%)
No
211 (79.0)
43 (20.4%)
168 (79.6%)
Lymphatic invasion
0.011
Yes
83 (31.1)
24 (28.9%)
59 (71.1%)
No
184 (68.9)
27 (14.7%)
157 (85.3%)
Vascular invasion
0.105
Yes
14 (5.2)
5 (35.7%)
9 (64.3%)
No
253 (94.8)
46 (18.2%)
207 (81.8%)
Recurrence
0.005
Yes
31 (11.0)
12 (38.7%)
19 (61.3%)
No
251 (89.0)
39 (15.5%)
212 (84.5%)
Age and size were reported as the mean ± SD. bEsophagogastric junction.