Clinical Presentation, Risk Factors, and Treatment Modalities of Hepatocellular Carcinoma: A Single Tertiary Care Center Experience
Table 6
Univariate and multivariate cox regression analysis of variables associated with poor survival in HCC patient.
Univariate analysis
Multivariate analysis
value
HR
95.0% CI
value
HR
95.0% CI
Lower
Upper
Lower
Upper
Symptomatic cases
0
2.157
1.501
3.101
Nonviral hepatitis
0.022
1.617
1.073
2.437
Multiple tumor (≥3)
0.00
2.996
2.019
4.446
0.000
2.679
1.577
4.552
Metastasis
0.00
5.195
3.242
8.324
Vascular invasion
0.00
3.849
2.25
6.586
CTP (B)
0.00
2.67
1.813
3.93
CTP (C)
0.00
4.31
2.531
7.339
BCLC (C)
0.00
18.776
4.382
80.445
0.044
6.283
1.052
37.545
BCLC (D)
0.001
10.921
2.51
47.511
0.000
2.679
1.577
4.552
Portal vein thrombosis
0.00
4.923
3.064
7.91
AGE
0.00
1.039
1.019
1.06
0.000
1.048
1.023
1.074
AST
0.00
1.004
1.003
1.005
0.000
1.006
1.003
1.009
ALT
0.031
1.002
1
1.005
0.001
0.993
0.989
0.997
BMI
0.024
0.964
0.934
0.995
Tumor size
0.00
1.078
1.045
1.111
Albumin
0.00
0.947
0.922
0.972
Creatinine
0.033
1.002
1
1.004
Platelets
0.006
1.002
1.001
1.003
MELD
0.00
1.069
1.045
1.094
CTP: Child-Turcotte-Pugh score; BCLC: Barcelona Clinic Liver Cancer; MELD: model for end-stage liver disease; AST: aspartate aminotransferase; ALT: alanine aminotransferase; BMI: body mass index.
