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Gastroenterology Research and Practice
Volume 2016, Article ID 2139489, 10 pages
http://dx.doi.org/10.1155/2016/2139489
Review Article

Single Nucleotide Polymorphisms as Prognostic and Predictive Factors of Adjuvant Chemotherapy in Colorectal Cancer of Stages I and II

1University Medical Centre Maribor, 2000 Maribor, Slovenia
2Faculty of Medicine, Centre for Human Molecular Genetics and Pharmacogenomics, University of Maribor, 2000 Maribor, Slovenia
3Faculty for Chemistry and Chemical Engineering, Laboratory for Biochemistry, Molecular Biology and Genomics, University of Maribor, 2000 Maribor, Slovenia
4University Medical Centre Ljubljana, 1000 Ljubljana, Slovenia

Received 24 July 2015; Accepted 11 November 2015

Academic Editor: Masood A. Shammas

Copyright © 2016 Matej Horvat et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. International Agency for Research on Cancer, World Cancer Report 2014, International Agency for Research on Cancer, World Health Organization, 2014.
  2. L. A. G. Ries, D. Melbert, M. Krapcho et al., SEER Cancer Statistics Review 1975–2005, National Cancer Institute, Rockville, Md, USA, 2007.
  3. S. Edge, D. Byrd, C. Compton et al., AJCC Cancer Staging Manual, Springer, New York, NY, USA, 7th edition, 2009.
  4. R. K. Kelley and A. P. Venook, “Prognostic and predictive markers in stage II colon cancer: is there a role for gene expression profiling?” Clinical Colorectal Cancer, vol. 10, no. 2, pp. 73–80, 2011. View at Publisher · View at Google Scholar · View at Scopus
  5. A. B. Benson III, D. Schrag, M. R. Somerfield et al., “American society of clinical oncology recommendations on adjuvant chemotherapy for stage II colon cancer,” Journal of Clinical Oncology, vol. 22, no. 16, pp. 3408–3419, 2004. View at Publisher · View at Google Scholar · View at Scopus
  6. P. F. Engstrom, P. J. Arnoletti, A. B. Benson et al., “NCCN clinical practice guidelines in oncology: colon cancer,” National Comprehensive Cancer Network, vol. 7, pp. 778–831, 2009. View at Google Scholar
  7. R. Labianca, B. Nordlinger, G. D. Beretta, A. Brouquet, and A. Cervantes, “Primary colon cancer: ESMO clinical practice guidelines for diagnosis, adjuvant treatment and follow-up,” Annals of Oncology, vol. 21, supplement 5, pp. v70–v77, 2010. View at Publisher · View at Google Scholar · View at Scopus
  8. H. J. Freeman, “Early stage colon cancer,” World Journal of Gastroenterology, vol. 19, no. 46, pp. 8468–8473, 2013. View at Publisher · View at Google Scholar · View at Scopus
  9. T. Akiyoshi, T. Kobunai, and T. Watanabe, “Recent approaches to identifying biomarkers for high-risk stage II colon cancer,” Surgery Today, vol. 42, no. 11, pp. 1037–1045, 2012. View at Publisher · View at Google Scholar · View at Scopus
  10. D. G. Nicastri, J. T. Doucette, T. E. Godfrey, and S. J. Hughes, “Is occult lymph node disease in colorectal cancer patients clinically significant? A review of the relevant literature,” Journal of Molecular Diagnostics, vol. 9, no. 5, pp. 563–571, 2007. View at Publisher · View at Google Scholar · View at Scopus
  11. S. C. Bruin, Y. He, I. Mikolajewska-Hanclich et al., “Molecular alterations associated with liver metastases development in colorectal cancer patients,” British Journal of Cancer, vol. 105, no. 2, pp. 281–287, 2011. View at Publisher · View at Google Scholar · View at Scopus
  12. A. Bolocan, D. Ion, D. N. Ciocan, and D. N. Paduraru, “Prognostic and predictive factors in colorectal cancer,” Chirurgia, vol. 107, no. 5, pp. 555–563, 2012. View at Google Scholar · View at Scopus
  13. H. C. van Wyk, J. Park, C. Roxburgh, P. Horgan, A. Foulis, and D. C. McMillan, “The role of tumour budding in predicting survival in patients with primary operable colorectal cancer: a systematic review,” Cancer Treatment Reviews, vol. 41, no. 2, pp. 151–159, 2015. View at Publisher · View at Google Scholar · View at Scopus
  14. S. Pernot, M. Terme, T. Voron et al., “Colorectal cancer and immunity: what we know and perspectives,” World Journal of Gastroenterology, vol. 20, no. 14, pp. 3738–3750, 2014. View at Publisher · View at Google Scholar · View at Scopus
  15. H. Ueno, Y. Kajiwara, H. Shimazaki et al., “New criteria for histologic grading of colorectal cancer,” The American Journal of Surgical Pathology, vol. 36, no. 2, pp. 193–201, 2012. View at Publisher · View at Google Scholar · View at Scopus
  16. I. D. Nagtegaal, C. A. M. Marijnen, E. K. Kranenbarg, C. J. H. Van De Velde, and J. H. J. M. Van Krieken, “Circumferential margin involvement is still an important predictor of local recurrence in rectal carcinoma: not one millimeter but two millimeters is the limit,” American Journal of Surgical Pathology, vol. 26, no. 3, pp. 350–357, 2002. View at Publisher · View at Google Scholar · View at Scopus
  17. S. C. Glasgow, J. I. S. Bleier, L. J. Burgart, C. O. Finne, and A. C. Lowry, “Meta-analysis of histopathological features of primary colorectal cancers that predict lymph node metastases,” Journal of Gastrointestinal Surgery, vol. 16, no. 5, pp. 1019–1028, 2012. View at Publisher · View at Google Scholar · View at Scopus
  18. I. Zlobec and A. Lugli, “Epithelial mesenchymal transition and tumor budding in aggressive colorectal cancer: tumor budding as oncotarget,” Oncotarget, vol. 1, no. 7, pp. 651–661, 2010. View at Publisher · View at Google Scholar · View at Scopus
  19. J. Galon, F. Pagès, F. M. Marincola et al., “Cancer classification using the immunoscore: a worldwide task force,” Journal of Translational Medicine, vol. 10, article 205, 2012. View at Publisher · View at Google Scholar
  20. C. Ratto, L. Sofo, M. Ippoliti et al., “Accurate lymph-node detection in colorectal cancer specimens resected for cancer is of prognostic significance,” Diseases of the Colon & Rectum, vol. 42, pp. 143–154, 1999. View at Google Scholar
  21. A. Mejia, S. Schulz, T. Hyslop, D. S. Weinberg, and S. A. Waldman, “Molecular staging individualizing cancer management,” Journal of Surgical Oncology, vol. 105, no. 5, pp. 468–474, 2012. View at Publisher · View at Google Scholar · View at Scopus
  22. D. G. Haller, P. J. Catalano, J. S. Macdonald et al., “Phase III study of fluorouracil, leucovorin, and levamisole in high-risk stage II and III colon cancer: final report of intergroup 0089,” Journal of Clinical Oncology, vol. 23, no. 34, pp. 8671–8678, 2005. View at Publisher · View at Google Scholar · View at Scopus
  23. C. Twelves, A. Wong, M. P. Nowacki et al., “Capecitabine as adjuvant treatment for stage III colon cancer,” The New England Journal of Medicine, vol. 352, no. 26, pp. 2696–2704, 2005. View at Publisher · View at Google Scholar · View at Scopus
  24. T. André, C. Boni, L. Mounedji-Boudiaf et al., “Oxaliplatin, fluorouracil, and leucovorin as adjuvant treatment for colon cancer,” The New England Journal of Medicine, vol. 350, no. 23, pp. 2343–2351, 2004. View at Publisher · View at Google Scholar · View at Scopus
  25. J. P. Kuebler, H. S. Wieand, M. J. O'Connell et al., “Oxaliplatin combined with weekly bolus fluorouracil and leucovorin as surgical adjuvant chemotherapy for stage II and III colon cancer: results from NSABP C-07,” Journal of Clinical Oncology, vol. 25, no. 16, pp. 2198–2204, 2007. View at Publisher · View at Google Scholar · View at Scopus
  26. D. G. Haller, J. Tabernero, J. Maroun et al., “Capecitabine plus oxaliplatin compared with fluorouracil and folinic acid as adjuvant therapy for stage III colon cancer,” Journal of Clinical Oncology, vol. 29, no. 11, pp. 1465–1471, 2011. View at Publisher · View at Google Scholar · View at Scopus
  27. W.-Q. Jiang, F.-F. Fu, Y.-X. Li et al., “Molecular biomarkers of colorectal cancer: prognostic and predictive tools for clinical practice,” Journal of Zhejiang University SCIENCE B, vol. 13, no. 9, pp. 663–675, 2012. View at Publisher · View at Google Scholar
  28. B. Chibaudel, C. Tournigand, T. André, A. K. Larsen, and A. De Gramont, “Targeted therapies as adjuvant treatment for early-stage colorectal cancer: first impressions and clinical questions,” Clinical Colorectal Cancer, vol. 9, no. 5, pp. 269–273, 2010. View at Publisher · View at Google Scholar · View at Scopus
  29. QUASAR Collaborative Group, “Adjuvant chemotherapy versus observation in patients with colorectal cancer: a randomised study,” The Lancet, vol. 370, no. 9604, pp. 2020–2029, 2007. View at Publisher · View at Google Scholar · View at Scopus
  30. E. Mamounas, S. Wieand, N. Wolmark et al., “Comparative efficiacy of adjuvant chemotherapy in patients with Dukes B versus Dukes C colon cancer: results from four National Surgical Adjuvant Breast and Bowel Project adjuvant studies,” Journal of Clinical Oncology, vol. 17, no. 5, pp. 1349–1355, 1999. View at Google Scholar
  31. International Multicentre Pooled Analysis of B2 Colon Cancer Trials (IMPACT B2) Investigators, “Efficacy of adjuvant fluorouracil and folinic acid in B2 colon cancer,” Journal of Clinical Oncology, vol. 17, no. 15, pp. 1356–1363, 1999. View at Google Scholar
  32. X. Wu, J. Zhang, X. He et al., “Postoperative adjuvant chemotherapy for stage II colorectal cancer: a systematic review of 12 randomized controlled trials,” Journal of Gastrointestinal Surgery, vol. 16, no. 3, pp. 646–655, 2012. View at Publisher · View at Google Scholar · View at Scopus
  33. G. Yothers, M. J. O'Connell, C. J. Allegra et al., “Oxaliplatin as adjuvant therapy for colon cancer: updated results of NSABP C-07 trial, including survival and subset analyses,” Journal of Clinical Oncology, vol. 29, no. 28, pp. 3768–3774, 2011. View at Publisher · View at Google Scholar · View at Scopus
  34. R. Dienstmann, R. Salazar, and J. Tabernero, “Personalizing colon cancer adjuvant therapy: selecting optimal treatments for individual patients,” Journal of Clinical Oncology, vol. 33, no. 16, pp. 1787–1796, 2015. View at Publisher · View at Google Scholar
  35. J. B. O'Connell, M. A. Maggard, and C. Y. Ko, “Colon cancer survival rates with the new American Joint Committee on Cancer sixth edition staging,” Journal of the National Cancer Institute, vol. 96, no. 19, pp. 1420–1425, 2004. View at Publisher · View at Google Scholar · View at Scopus
  36. K. T. Huynh and D. S. B. Hoon, “Epigenetics of regional lymph node metastasis in solid tumors,” Clinical and Experimental Metastasis, vol. 29, no. 7, pp. 747–756, 2012. View at Publisher · View at Google Scholar · View at Scopus
  37. R. Kanthan, J.-L. Senger, and S. C. Kanthan, “Molecular events in primary and metastatic colorectal carcinoma: a review,” Pathology Research International, vol. 2012, Article ID 597497, 14 pages, 2012. View at Publisher · View at Google Scholar · View at Scopus
  38. R. M. Goldberg, I. Tabah-Fisch, H. Bleiberg et al., “Pooled analysis of safety and efficacy of oxaliplatin plus fluorouracil/leucovorin administered bimonthly in elderly patients with colorectal cancer,” Journal of Clinical Oncology, vol. 24, no. 25, pp. 4085–4091, 2006. View at Publisher · View at Google Scholar · View at Scopus
  39. P. A. Jones and S. B. Baylin, “The epigenomics of cancer,” Cell, vol. 128, no. 4, pp. 683–692, 2007. View at Publisher · View at Google Scholar · View at Scopus
  40. M. Dean, T. Fojo, and S. Bates, “Tumour stem cells and drug resistance,” Nature Reviews Cancer, vol. 5, no. 4, pp. 275–284, 2005. View at Publisher · View at Google Scholar · View at Scopus
  41. F. T. Bosman and P. Yan, “Molecular pathology of colorectal cancer,” Polish Journal of Pathology, vol. 65, no. 4, pp. 257–266, 2014. View at Publisher · View at Google Scholar · View at Scopus
  42. S. Popat, R. Hubner, and R. S. Houlston, “Systematic review of microsatellite instability and colorectal cancer prognosis,” Journal of Clinical Oncology, vol. 23, no. 3, pp. 609–618, 2005. View at Publisher · View at Google Scholar · View at Scopus
  43. G. des Guetz, O. Schischmanoff, P. Nicolas, G.-Y. Perret, J.-F. Morere, and B. Uzzan, “Does microsatellite instability predict the efficacy of adjuvant chemotherapy in colorectal cancer? A systematic review with meta-analysis,” European Journal of Cancer, vol. 45, no. 10, pp. 1890–1896, 2009. View at Publisher · View at Google Scholar · View at Scopus
  44. Z. Saridaki, J. Souglakos, and V. Georgoulias, “Prognostic and predictive significance of MSI in stages II/III colon cancer,” World Journal of Gastroenterology, vol. 20, no. 22, pp. 6809–6814, 2014. View at Publisher · View at Google Scholar · View at Scopus
  45. G. Lech, R. Slotwinski, and I. W. Krasnodebski, “The role of tumour markers and biomarkers in colorectal cancer,” Neoplasma, vol. 61, no. 1, pp. 1–8, 2014. View at Publisher · View at Google Scholar · View at Scopus
  46. M. M. Bertagnolli, D. Niedzwiecki, C. C. Compton et al., “Microsatellite instability predicts improved response to adjuvant therapy with irinotecan, fluorouracil, and leucovorin in stage III colon cancer. Cancer and Leukemia Group B Protocol 89803,” Journal of Clinical Oncology, vol. 27, no. 11, pp. 1814–1821, 2009. View at Publisher · View at Google Scholar
  47. A. de la Chapelle, “Genetic predisposition to colorectal cancer,” Nature Reviews Cancer, vol. 4, no. 10, pp. 769–780, 2004. View at Publisher · View at Google Scholar · View at Scopus
  48. A. de la Chapelle, “The incidence of Lynch syndrome,” Familial Cancer, vol. 4, no. 3, pp. 233–237, 2005. View at Publisher · View at Google Scholar · View at Scopus
  49. I. N. Mates, V. Jinga, I. E. Csiki et al., “Single nucleotide polymorphisms in colorectal cancer: associations with tumor site and TNM stage,” Journal of Gastrointestinal and Liver Diseases, vol. 21, no. 1, pp. 45–52, 2012. View at Google Scholar · View at Scopus
  50. P. Lichtenstein, N. V. Holm, P. K. Verkasalo et al., “Environmental and heritable factors in the causation of cancer-analyses of cohorts of twins from Sweden, Denmark, and Finland,” The New England Journal of Medicine, vol. 343, no. 2, pp. 78–85, 2000. View at Publisher · View at Google Scholar · View at Scopus
  51. M. W. Nachman, “Single nucleotide polymorphisms and recombination rate in humans,” Trends in Genetics, vol. 17, no. 9, pp. 481–485, 2001. View at Publisher · View at Google Scholar · View at Scopus
  52. K. Mimori, F. Tanaka, K. Shibata, and M. Mori, “Review: single nucleotide polymorphisms associated with the oncogenesis of colorectal cancer,” Surgery Today, vol. 42, no. 3, pp. 215–219, 2012. View at Publisher · View at Google Scholar · View at Scopus
  53. M. A. Varela and W. Amos, “Heterogeneous distribution of SNPs in the human genome: microsatellites as predictors of nucleotide diversity and divergence,” Genomics, vol. 95, no. 3, pp. 151–159, 2010. View at Publisher · View at Google Scholar · View at Scopus
  54. T. A. Manolio, “Genomewide association studies and assessment of the risk of disease,” The New England Journal of Medicine, vol. 363, no. 2, pp. 166–176, 2010. View at Publisher · View at Google Scholar
  55. M. Aiello, N. Vella, C. Cannavò et al., “Role of genetic polymorphisms and mutations in colorectal cancer therapy,” Molecular Medicine Reports, vol. 4, no. 2, pp. 203–208, 2011. View at Publisher · View at Google Scholar · View at Scopus
  56. A. de Gramont, A. Figer, M. Seymour et al., “Leucovorin and fluorouracil with or without oxaliplatin as first-line treatment in advanced colorectal cancer,” Journal of Clinical Oncology, vol. 18, no. 16, pp. 2938–2947, 2000. View at Google Scholar · View at Scopus
  57. Y. Dong, J. W. Liu, Y. J. Gao, T. Zhou, and Y. M. Chen, “Relationship between DNA repair gene XPD751 single-nucleotide polymorphisms and prognosis of colorectal cancer,” Genetics and Molecular Research, vol. 14, no. 2, pp. 5390–5398, 2015. View at Publisher · View at Google Scholar
  58. J. Stoehlmacher, V. Ghaderi, S. Iqbal et al., “A polymorphism of the XRCC1 gene predicts for response to platinum based treatment in advanced colorectal cancer,” Anticancer Research, vol. 21, no. 4, pp. 3075–3079, 2001. View at Google Scholar · View at Scopus
  59. F. Ye, Z. Liu, A. Tan, M. Liao, Z. Mo, and X. Yang, “XRCC1 and GSTP1 polymorphisms and prognosis of oxaliplatin-based chemotherapy in colorectal cancer: a meta-analysis,” Cancer Chemotherapy and Pharmacology, vol. 71, no. 3, pp. 733–740, 2013. View at Publisher · View at Google Scholar · View at Scopus
  60. J. Stoehlmacher, D. J. Park, W. Zhang et al., “Association between glutathione S-transferase P1, T1, and M1 genetic polymorphism and survival of patients with metastatic colorectal cancer,” Journal of the National Cancer Institute, vol. 94, no. 12, pp. 936–942, 2002. View at Publisher · View at Google Scholar · View at Scopus
  61. J. H. Park, N. S. Kim, J. Y. Park et al., “MGMT −535G>T polymorphism is associated with prognosis for patients with metastatic colorectal cancer treated with oxaliplatin-based chemotherapy,” Journal of Cancer Research and Clinical Oncology, vol. 136, no. 8, pp. 1135–1142, 2010. View at Publisher · View at Google Scholar
  62. M.-C. Etienne-Grimaldi, G. Milano, F. Maindrault-Gœbel et al., “Methylenetetrahydrofolate reductase (MTHFR) gene polymorphisms and FOLFOX response in colorectal cancer patients,” British Journal of Clinical Pharmacology, vol. 69, no. 1, pp. 58–66, 2010. View at Publisher · View at Google Scholar · View at Scopus
  63. O. Castillo-Fernandeza, M. Santibanezb, A. Bauzab et al., “Methylenetetetrahydrofolate reductase polymorphism (677C>T) predicts long time to progression in metastatic colorectal cancer treated with 5-fluorouracil and folinic acid,” Archives of Medical Research, vol. 41, pp. 430–435, 2010. View at Google Scholar
  64. E. Cecchin, G. Perrone, S. Nobili et al., “MTHFR-1298 A>C (rs1801131) is a predictor of survival in two cohorts of stage II/III colorectal cancer patients treated with adjuvant fluoropyrimidine chemotherapy with or without oxaliplatin,” The Pharmacogenomics Journal, vol. 15, pp. 219–225, 2015. View at Publisher · View at Google Scholar · View at Scopus
  65. E. J. Kap, S. Richter, A. Rudolph et al., “Genetic variants in the glutathione S-transferase genes and survival in colorectal cancer patients after chemotherapy and differences according to treatment with oxaliplatin,” Pharmacogenetics and Genomics, vol. 24, no. 7, pp. 340–347, 2014. View at Publisher · View at Google Scholar · View at Scopus
  66. G. Absenger, L. Benhaim, J. Szkandera et al., “The cyclin D1 (CCND1) rs9344 G>A polymorphism predicts clinical outcome in colon cancer patients treated with adjuvant 5-FU-based chemotherapy,” Pharmacogenomics Journal, vol. 14, no. 2, pp. 130–134, 2014. View at Publisher · View at Google Scholar · View at Scopus
  67. D. Páez, A. Gerger, W. Zhang et al., “Association of common gene variants in the WNT/β-catenin pathway with colon cancer recurrence,” Pharmacogenomics Journal, vol. 14, no. 2, pp. 142–150, 2014. View at Publisher · View at Google Scholar · View at Scopus
  68. D. Caronia, M. Martin, J. Sastre et al., “A polymorphism in the cytidine deaminase promoter predicts severe capecitabine-induced hand-foot syndrome,” Clinical Cancer Research, vol. 17, no. 7, pp. 2006–2013, 2011. View at Publisher · View at Google Scholar · View at Scopus
  69. M. Gusella, A. C. Frigo, C. Bolzonella et al., “Predictors of survival and toxicity in patients on adjuvant therapy with 5-fluorouracil for colorectal cancer,” British Journal of Cancer, vol. 100, no. 10, pp. 1549–1557, 2009. View at Publisher · View at Google Scholar · View at Scopus
  70. A. A. Argyriou, G. Cavaletti, A. Antonacopoulou et al., “Voltage-gated sodium channel polymorphisms play a pivotal role in the development of oxaliplatin-induced peripheral neurotoxicity: results from a prospective multicenter study,” Cancer, vol. 119, no. 19, pp. 3570–3577, 2013. View at Publisher · View at Google Scholar · View at Scopus
  71. A. Custodio, J. Moreno-Rubio, J. Aparicio et al., “Pharmacogenetic predictors of severe peripheral neuropathy in colon cancer patients treated with oxaliplatin-based adjuvant chemotherapy: a GEMCAD group study,” Annals of Oncology, vol. 25, no. 2, Article ID mdt546, pp. 398–403, 2014. View at Publisher · View at Google Scholar · View at Scopus
  72. K. Jin, W. Gao, Y. Lu, H. Lan, L. Teng, and F. Cao, “Mechanisms regulating colorectal cancer cell metastasis into liver (review),” Oncology Letters, vol. 3, no. 1, pp. 11–15, 2012. View at Publisher · View at Google Scholar · View at Scopus
  73. O. Kollmar, K. Rupertus, C. Scheuery et al., “Stromal cell-derived factor-1 promotes cell migration and tumor growth of colorectal metastasis,” Neoplasia, vol. 9, no. 10, pp. 862–870, 2007. View at Publisher · View at Google Scholar · View at Scopus
  74. B. Gentner, A. Wein, R. S. Croner et al., “Differences in the gene expression profile of matrix metalloproteinases (MMPs) and their inhibitors (TIMPs) in primary colorectal tumors and their synchronous liver metastases,” Anticancer Research, vol. 29, no. 1, pp. 67–74, 2009. View at Google Scholar · View at Scopus
  75. M. Illemann, N. Bird, A. Majeed et al., “MMP-9 is differentially expressed in primary human colorectal adenocarcinomas and their metastases,” Molecular Cancer Research, vol. 4, no. 5, pp. 293–302, 2006. View at Publisher · View at Google Scholar · View at Scopus
  76. S. Koskensalo, J. Louhimo, S. Nordling, J. Hagström, and C. Haglund, “MMP-7 as a prognostic marker in colorectal cancer,” Tumor Biology, vol. 32, no. 2, pp. 259–264, 2011. View at Publisher · View at Google Scholar · View at Scopus
  77. H. Kanzaki, M. Ouchida, H. Hanafusa et al., “Single nucleotide polymorphism in the RAD18 gene and risk of colorectal cancer in the Japanese population,” Oncology Reports, vol. 18, no. 5, pp. 1171–1175, 2007. View at Google Scholar · View at Scopus
  78. U. Stein, W. Walther, F. Arlt et al., “MACC1, a newly identified key regulator of HGF-MET signaling, predicts colon cancer metastasis,” Nature Medicine, vol. 15, no. 1, pp. 59–67, 2009. View at Publisher · View at Google Scholar · View at Scopus
  79. N. Yoshitake, H. Fukui, H. Yamagishi et al., “Expression of SDF-1α and nuclear CXCR4 predicts lymph node metastasis in colorectal cancer,” British Journal of Cancer, vol. 98, no. 10, pp. 1682–1689, 2008. View at Publisher · View at Google Scholar · View at Scopus
  80. R. Matsusue, H. Kubo, S. Hisamori et al., “Hepatic stellate cells promote liver metastasis of colon cancer cells by the action of SDF-1/CXCR4 axis,” Annals of Surgical Oncology, vol. 16, no. 9, pp. 2645–2653, 2009. View at Publisher · View at Google Scholar · View at Scopus
  81. I. Kryczek, S. Wei, E. Keller, R. Liu, and W. Zou, “Stroma-derived factor (SDF-1/CXCL12) and human tumor pathogenesis,” The American Journal of Physiology—Cell Physiology, vol. 292, no. 3, pp. C987–C995, 2007. View at Publisher · View at Google Scholar · View at Scopus
  82. A. Zafiropoulos, N. Crikas, A. M. Passam, and D. A. Spandidos, “Significant involvement of CCR2-64I and CXCL12-3a in the development of sporadic breast cancer,” Journal of Medical Genetics, vol. 41, article e59, 2004. View at Publisher · View at Google Scholar · View at Scopus
  83. A. Coelho, C. Calçada, R. Catarino, D. Pinto, G. Fonseca, and R. Medeiros, “CXCL12-3′ A polymorphism and lung cancer metastases protection: new perspectives in immunotherapy?” Cancer Immunology, Immunotherapy, vol. 55, no. 6, pp. 639–643, 2006. View at Publisher · View at Google Scholar · View at Scopus
  84. F. Dommange, G. Cartron, C. Espanel et al., “CXCL12 polymorphism and malignant cell dissemination/tissue infiltration in acute myeloid leukemia,” The FASEB Journal, vol. 20, no. 11, pp. 1913–1915, 2006. View at Publisher · View at Google Scholar · View at Scopus
  85. S. Hassan, A. Baccarelli, O. Salvucci, and M. Basik, “Plasma stromal cell-derived factor-1: host derived marker predictive of distant metastasis in breast cancer,” Clinical Cancer Research, vol. 14, no. 2, pp. 446–454, 2008. View at Publisher · View at Google Scholar · View at Scopus
  86. S.-C. Chang, P.-C. Lin, S.-H. Yang, H.-S. Wang, A. F.-Y. Li, and J.-K. Lin, “SDF-1alpha G801A polymorphism predicts lymph node metastasis in stage T3 colorectal cancer,” Annals of Surgical Oncology, vol. 16, no. 8, pp. 2323–2330, 2009. View at Publisher · View at Google Scholar · View at Scopus
  87. I. Cañadas, Á. Taus, I. González et al., “High circulating hepatocyte growth factor levels associate with epithelial to mesenchymal transition and poor outcome in small cell lung cancer patients,” Oncotarget, vol. 5, no. 14, pp. 5246–5256, 2014. View at Publisher · View at Google Scholar · View at Scopus
  88. D. Ji, Z.-T. Lu, Y.-Q. Li et al., “MACC1 expression correlates with PFKFB2 and survival in hepatocellular carcinoma,” Asian Pacific Journal of Cancer Prevention, vol. 15, no. 2, pp. 999–1003, 2014. View at Publisher · View at Google Scholar · View at Scopus
  89. K. Zhang, F. Tian, Y. Zhang et al., “MACC1 is involved in the regulation of proliferation, colony formation, invasion ability, cell cycle distribution, apoptosis and tumorigenicity by altering Akt signaling pathway in human osteosarcoma,” Tumor Biology, vol. 35, no. 3, pp. 2537–2548, 2014. View at Publisher · View at Google Scholar · View at Scopus
  90. B. Ren, V. Zakharov, Q. Yang, L. McMahon, J. Yu, and W. Cao, “MACC1 is related to colorectal cancer initiation and early-stage invasive growth,” American Journal of Clinical Pathology, vol. 140, no. 5, pp. 701–707, 2013. View at Publisher · View at Google Scholar · View at Scopus
  91. U. Stein, M. Dahlmann, and W. Walther, “MACC1-more than metastasis? Facts and predictions about a novel gene,” Journal of Molecular Medicine, vol. 88, no. 1, pp. 11–18, 2010. View at Publisher · View at Google Scholar · View at Scopus
  92. F. Arlt and U. Stein, “Colon cancer metastasis: MACC1 and Met as metastatic pacemakers,” The International Journal of Biochemistry and Cell Biology, vol. 41, no. 12, pp. 2356–2359, 2009. View at Publisher · View at Google Scholar · View at Scopus
  93. A. H. Lang, S. Geller-Rhomberg, T. Winder et al., “A common variant of the MACC1 gene is significantly associated with overall survival in colorectal cancer patients,” BMC Cancer, vol. 12, article 20, 2012. View at Publisher · View at Google Scholar · View at Scopus
  94. F. Schmid, S. Burock, K. Klockmeier, P. M. Schlag, and U. Stein, “SNPs in the coding region of the metastasis-inducing gene MACC1 and clinical outcome in colorectal cancer,” Molecular Cancer, vol. 11, article 49, 2012. View at Publisher · View at Google Scholar · View at Scopus
  95. L. Ting, H. Jun, and C. Junjie, “RAD18 lives a double life: its implication in DNA double-strand break repair,” DNA Repair, vol. 9, no. 12, pp. 1241–1248, 2010. View at Publisher · View at Google Scholar · View at Scopus
  96. S. Tateishi, Y. Sakuraba, S. Masuyama, H. Inoue, and M. Yamaizumi, “Dysfunction of human Rad18 results in defective postreplication repair and hypersensitivity to multiple mutagens,” Proceedings of the National Academy of Sciences of the United States of America, vol. 97, no. 14, pp. 7927–7932, 2000. View at Publisher · View at Google Scholar · View at Scopus
  97. J. Pan, P. Chi, X. Lu, and Z. Xu, “Genetic polymorphisms in translesion synthesis genes are associated with colorectal cancer risk and metastasis in Han Chinese,” Gene, vol. 504, no. 2, pp. 151–155, 2012. View at Publisher · View at Google Scholar · View at Scopus
  98. K. A. Paschos, D. Canovas, and N. C. Bird, “Enzymatic function of multiple origins regulates the progression of colorectal cancer and the development of metastases,” Hippokratia, vol. 13, no. 1, pp. 23–31, 2009. View at Google Scholar · View at Scopus
  99. C. Amalinei, I. D. Caruntu, S. E. Giusca, and R. A. Bălan, “Matrix metalloproteinases involvement in pathologic conditions,” Romanian Journal of Morphology and Embryology, vol. 51, no. 2, pp. 215–228, 2010. View at Google Scholar
  100. K. Brew, D. Dinakarpandian, and H. Nagase, “Tissue inhibitors of metalloproteinases: evolution, structure and function,” Biochimica et Biophysica Acta—Protein Structure and Molecular Enzymology, vol. 1477, no. 1-2, pp. 267–283, 2000. View at Publisher · View at Google Scholar · View at Scopus
  101. L. Herszényi, I. Hritz, G. Lakatos, M. Z. Varga, and Z. Tulassay, “The Behavior of matrix metalloproteinases and their inhibitors in colorectal cancer,” International Journal of Molecular Sciences, vol. 13, no. 10, pp. 13240–13263, 2012. View at Publisher · View at Google Scholar · View at Scopus
  102. V. Şurlin, M. Ioana, and I. E. Pleşea, “Genetic patterns of metalloproteinases and their tissular inhibitors-clinicopathologic and prognostic significance in colorectal cancer,” Romanian Journal of Morphology and Embryology, vol. 52, no. 1, pp. 231–236, 2011. View at Google Scholar · View at Scopus
  103. A. V. Chernov, N. E. Sounni, A. G. Remacle, and A. Y. Strongin, “Epigenetic control of the invasion-promoting MT1-MMP/MMP-2/TIMP-2 axis in cancer cells,” Journal of Biological Chemistry, vol. 284, no. 19, pp. 12727–12734, 2009. View at Publisher · View at Google Scholar · View at Scopus
  104. K. S. Park, S. J. Kim, K. H. Kim, and J. C. Kim, “Clinical characteristics of TIMP2, MMP2, and MMP9 gene polymorphisms in colorectal cancer,” Journal of Gastroenterology and Hepatology, vol. 26, no. 2, pp. 391–397, 2011. View at Publisher · View at Google Scholar · View at Scopus
  105. Ł. Dziki, K. Przybyłowska, I. Majsterek, R. Trzciński, and M. Sygut, “A/G Polymorphism of the MMP-7 gene promoter region in colorectal cancer,” Polski Przeglad Chirurgiczny, vol. 83, no. 11, pp. 622–626, 2011. View at Publisher · View at Google Scholar · View at Scopus
  106. L.-L. Xing, Z.-N. Wang, L. Jiang et al., “Matrix metalloproteinase-9-1562C>T polymorphism may increase the risk of lymphatic metastasis of colorectal cancer,” World Journal of Gastroenterology, vol. 13, no. 34, pp. 4626–4629, 2007. View at Publisher · View at Google Scholar · View at Scopus