TY - JOUR A2 - Nandi, Bisweswar AU - Moravkova, Paula AU - Kohoutova, Darina AU - Rejchrt, Stanislav AU - Cyrany, Jiri AU - Bures, Jan PY - 2016 DA - 2016/01/06 TI - Role of S100 Proteins in Colorectal Carcinogenesis SP - 2632703 VL - 2016 AB - The family of S100 proteins represents 25 relatively small (9–13 kD) calcium binding proteins. These proteins possess a broad spectrum of important intracellular and extracellular functions. Colorectal cancer is the third most common cancer in men (after lung and prostate cancer) and the second most frequent cancer in women (after breast cancer) worldwide. S100 proteins are involved in the colorectal carcinogenesis through different mechanisms: they enable proliferation, invasion, and migration of the tumour cells; furthermore, S100 proteins increase angiogenesis and activate NF-κβ signaling pathway, which plays a key role in the molecular pathogenesis especially of colitis-associated carcinoma. The expression of S100 proteins in the cancerous tissue and serum levels of S100 proteins might be used as a precise diagnostic and prognostic marker in patients with suspected or already diagnosed colorectal neoplasia. Possibly, in the future, S100 proteins will be a therapeutic target for tailored anticancer therapy. SN - 1687-6121 UR - https://doi.org/10.1155/2016/2632703 DO - 10.1155/2016/2632703 JF - Gastroenterology Research and Practice PB - Hindawi Publishing Corporation KW - ER -