Role of S100 Proteins in Colorectal Carcinogenesis

Table 1

Association of S100 proteins with different types of gastrointestinal cancer.

Cancer site	Type of S100 protein	S100 regulated features	References
Colon	S100A8/A9, S100A4, S100A6, S100A11, S100B, S100P	↑	[25–28, 31–33, 41–47]
Oesophagus	S100A2	↓ in ESCC; ↑ in adenocarcinoma	[48, 49]
	S100A9	↑ in adenocarcinoma	[50]
Stomach	S100A2, S100A14	↓	[51, 52]
	S100A2, S100A3, S100A4, S100A6–S100A10	↑	[53–57]
Pancreas	S100A2	Dysregulated	[58]
	S100A4, S100P	↑	[59]
	S100A11	↑ in early stage, ↓ in tumour progression	[60]

ESCC, oesophageal squamous cell carcinoma; ↑, upregulated; ↓, downregulated.