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Gastroenterology Research and Practice
Volume 2016, Article ID 4953120, 12 pages
Research Article

Treatment with a Monoclonal Anti-IL-12p40 Antibody Induces Substantial Gut Microbiota Changes in an Experimental Colitis Model

1Department of Food Science, Faculty of Science, University of Copenhagen, Rolighedsvej 26, 1958 Frederiksberg, Denmark
2Department of Veterinary Disease Biology, Faculty of Health and Medical Science, University of Copenhagen, Thorvaldsensvej 57, 1870 Frederiksberg, Denmark
3Department of Environmental Science, Aarhus University, Frederiksborgvej 399, 4000 Roskilde, Denmark
4Novo Nordisk Park, 2760 Maaloev, Denmark

Received 24 September 2015; Accepted 30 November 2015

Academic Editor: Jinsheng Yu

Copyright © 2016 Josué Castro-Mejía et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

Supplemental Material includes a Supplemental Figure and 4 Supplemental Tables. The Supplemental Figure contains DGGE profiles of 16S rRNA gene-amplicon of fecal, colon and cecum samples. The Supplemental Tables contain Murine endoscopic index of colitis severity (Supplemental Table 1), criteria for assignment of histopathology damage (Supplemental Table 2), bacterial richness as the number of OTU-species observed in colonic content (Supplemental Table 3) and r-values for significant correlations of immunological and host parameters with GM members (Supplemental Table 4).

  1. Supplementary Material