Gastroenterology Research and Practice / 2016 / Article / Tab 1

Review Article

The C825T Polymorphism of the G-Protein β3 Gene as a Risk Factor for Functional Dyspepsia: A Meta-Analysis

Table 1

Characteristics of included studies in the meta-analysis.

AuthorYearCountryEthnicity Mean age
(FD/control)
Gender
(male/female)
Definition of FDGenotyping methodFunctional dyspepsiaControlsHWE NOS Score
TotalCCCTTTTotalCCCTTT

Holtmann et al. [24]2004AmericaAmerican46.4 ± 1.9/44.4 ± 1.360/108Rome IIPCR-RFLP56341841124662405
Camilleri et al. [25]2006AmericaCaucasian55/6044/45Rome IIDirect sequencing503210839172110.076
Li et al. [32]2006ChinaChinese48.9 ± 9.9/46.2 ± 8.9112/132Rome IIPCR-RFLP1022141401423855490.015
Tahara et al. [33]2008JapanJapanese60.1 ± 13.1/61.1 ± 13.1130/53Rome IIPCR-RFLP89203831942348230.847
van Lelyveld et al. [34]2008NetherlandsCaucasian42.3 ± 1/41.9 ± 1115/333Rome IIMolecular beacon assay112485410336180126300.256
de Vries et al. [35]2009AmericaAmerican49.7 ± 12.3/40.1 ± 12.3182/319Rome IIMolecular beacon assay128605612373199138360.15
Oshima et al. [26]2010JapanJapanese43/45350/479Rome IIITaqMan Assay681729227611913682020.376
Shimpuku et al. [36]2011JapanJapanese59.2 ± 14.2/37.2 ± 9.1393/45Rome IIIDirect sequencing74144416641728190.328
Kim et al. [27]2012KoreaKorean49 ± 15/47 ± 15229/372Rome IIITaqMan Assay1675276394341122151070.858
Park and Uhm [37]2012KoreaKorean11.2 ± 3.6/10.8 ± 3.9113/137Rome IIISingle base primer extension assay1023739261483579340.418
Chung et al. [38]2014KoreaKorean46.8 ± 15.7/50.5 ± 11.162/69Rome III PCR-RFLP5052718811551150.028
Hwang et al. [39]2014KoreaKorean50/54147/234Rome III PCR-RFLP11120622926964132730.776

HWE, Hardy-Weinberg equilibrium; NOS, Newcastle-Ottawa Scale.

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