Review Article
The C825T Polymorphism of the G-Protein β3 Gene as a Risk Factor for Functional Dyspepsia: A Meta-Analysis
Table 2
Meta-analysis of the association between GNB3 gene C825T polymorphism and functional dyspepsia risk.
| Comparisons | OR (95% CI) | value | | Egger’s test |
| CC versus TT | | | | | Overall | 1.15 (0.93–1.44) | 0.20 | 0 | 0.015 | Asia | 1.12 (0.87–1.43) | 0.37 | 18% | 0.049 | America | 1.34 (0.74–2.42) | 0.34 | 0 | 0.291 | Rome II | 1.40 (0.98–1.98) | 0.06 | 0 | 0.147 | Rome III | 1.02 (0.77–1.35) | 0.87 | 27% | 0.101 | PCR-RFLP | 1.55 (1.07–2.24) | 0.02 | 0 | 0.320 | HWE | 1.06 (0.84–1.35) | 0.63 | 0 | 0.033 | IBS | 1.16 (0.92–1.46) | 0.21 | 1% | 0.031 | NOS Score | 1.12 (0.87–1.43) | 0.38 | 15% | 0.015 | CC + CT versus TT | | | | | Overall | 1.16 (0.97–1.39) | 0.11 | 12% | 0.057 | Asia | 1.14 (0.94–1.39) | 0.19 | 19% | 0.304 | America | 1.40 (0.80–2.44) | 0.24 | 46% | 0.097 | Rome II | 1.32 (0.98–1.77) | 0.07 | 0 | 0.126 | Rome III | 1.08 (0.86–1.35) | 0.53 | 29% | 0.475 | PCR-RFLP | 1.33 (1.00–1.77) | 0.05 | 19% | 0.171 | HWE | 1.08 (0.88–1.32) | 0.44 | 0 | 0.180 | IBS | 1.17 (0.97–1.41) | 0.10 | 19% | 0.052 | NOS Score | 1.15 (0.94–1.41) | 0.17 | 31% | 0.103 | CT + TT versus CC | | | | | Overall | 1.01 (0.77–1.31) | 0.96 | 59% | 0.818 | Asia | 1.00 (0.82–1.23) | 0.97 | 42% | 0.078 | America | 0.67 (0.30–1.50) | 0.33 | 80% | 0.215 | Rome II | 0.99 (0.66–1.49) | 0.96 | 67% | 0.098 | Rome III | 1.00 (0.70–1.43) | 0.99 | 52% | 0.157 | PCR-RFLP | 1.11 (0.69–1.80) | 0.67 | 59% | 0.790 | HWE | 1.02 (0.77–1.34) | 0.91 | 56% | 0.603 | IBS | 0.98 (0.73–1.31) | 0.87 | 60% | 0.520 | NOS Score | 1.02 (0.75–1.38) | 0.92 | 56% | 0.807 | C versus T | | | | | Overall | 1.06 (0.96–1.18) | 0.26 | 25% | 0.915 | Asia | 1.06 (0.93–1.20) | 0.39 | 26% | 0.082 | America | 0.97 (0.76–1.25) | 0.84 | 42% | 0.384 | Rome II | 1.14 (0.97–1.33) | 0.11 | 17% | 0.094 | Rome III | 1.01 (0.87–1.16) | 0.93 | 31% | 0.190 | PCR-RFLP | 1.16 (0.97–1.38) | 0.10 | 43% | 0.884 | HWE | 1.04 (0.93–1.17) | 0.47 | 0 | 0.934 | IBS | 1.05 (0.94–1.17) | 0.40 | 30% | 0.730 | NOS Score | 1.06 (0.94–1.19) | 0.37 | 24% | 0.435 |
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HWE, Hardy-Weinberg equilibrium; IBS, irritable bowel syndrome; PCR-RFLP, polymerase chain reaction-restriction fragment-length polymorphism; NOS, Newcastle-Ottawa Scale.
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